Quercetin Glucosides are Hydrolyzed to Quercetin in Human Oral Cavity to Participate in Peroxidase-Dependent Scavenging of Hydrogen Peroxide

Food Science and Technology Research

Volumn 7, Issue 3, 2001, Pages 239-245

  Hirota, Sachiko ^a   Nishioka, Takahiro ^b   Shimoda, Taeko ^a   Miura, Keiko ^b   Ansai, Toshihiro ^b   Takahama, Umeo ^b  

^a KYUSHU WOMEN'S UNIVERSITY   (Japan)

^b KYUSHU DENTAL COLLEGE   (Japan)

Author keywords

H2O2 scavenging; Metabolism of quercetin and the glucoside; Onion (Allium cepa); Oral cavity; Peroxidase in saliva

Indexed keywords

ALLIUM CEPA;

EID: 0009804937     PISSN: 13446606     EISSN: None     Source Type: Journal    
DOI: 10.3136/fstr.7.239     Document Type: Article

References (25)

1. al-Essa, L., Niwa, M., Kohno, K. and Tsurumi, K. (1994). A proposal for purification of salivary palymorphonuclear leukocytes by combination of nylon mesh filtration and density-gradient method: a validation by superoxide-and cyclic AMP-generating responses. Life Sci., 55, PL333-338.
2. Carrol, K.K., Guthrie, N., So, F.V. and Chambers, A.F. (1997). Anticancer properties of flavonoids, with emphasis on citrus flavonoids. In "Flavonoids in Health and Disease," ed. by C.A. Rice-Evans & L. Packer, Marcel Dekker, New York, pp. 437-446.
3. Dodds, M.W.J. and Johnson, D.A. (1993), Influence of mastication on saliva, plaque pH and masseter muscle activity in man. Arch. Oral Biol., 38, 623-626.
4. Graham, G. and Rowland, M. (1972). Application of salivary salicylate data on biopharmaceutical studies of salicylates. J. Pharm. Sci., 61, 1219-1224.
5. Hertog, M.G.L. and Katan, M.B. (1997). Quercetin in foods, cardiovascular disease, and cancer. In "Flavonoids in Health and Disease," ed. by C.A. Rice-Evans, & L. Packer, Marcel Dekker, New York, pp. 447-468.
6. Hirota, S., Shimoda, T. and Takahama, U. (1998). Tissue and spatial distribution of flavonol and peroxidase in onion bulbs and stability of flavonol glucosides during boiling of the scales. J. Agric. Food Chem., 46, 3497-3502.
7. Hirota, S., Shimoda, T. and Takahama, U. (1999). Distribution of flavonols and enzymes participating in the metabolism in bulbs: Mechanism of accumulation of quercetin and its glucosides in the abaxial epidermis. Food Sci. Technol. Res., 5, 384-387.
8. Hollman, P.C.H., Bijsman, M.N.C.P., van Gameren, Y., Cnossen, E.P.J., de Vries, J.H.M. and Katan, M.B. (1999). The sugar moiety is a major determinant of the absorption of dietary flavonoid glycosides in man. Free Rad. Res., 31, 569-573.
9. Hollman, P.C.H., Gaag, M.V.D., Mengelers, M.J.B., van Trip, J.M.P., de Vries, J.H.M. and Katan, M.B. (1996). Absorption and disposition kinetics of the dietary antioxidant quercetin in man. Free Rad. Biol. Med., 21, 703-707.
10. Hollman, P.C.H. and Katan, M.B. (1997). Absorption, metabolism, and unavailability of flavonoids. In "Flavonoids in Health and Disease," ed. by C.A. Rice-Evans & L. Packer, Marcel Dekker, New York, pp. 483-521.
11. Hösel, W. and Barz, W. (1972). Enzymatic transformation of flavonols with a cell-free preparation from Cicer arietinum L. Biochim. Biophys. Acta, 261, 294-303.
12. Makinen, K.K. (1998). Salivary Enzymes In "Human Saliva. Clinical Chemistry and Microbiology," ed. by J. Tenovuo. CRC Press, Boca Raton, pp. 93-119.
13. Nakamura, M. and Slots, J. (1983). Salivary enzymes. J. Periodontal Res., 18, 559-604.
14. Nishioka, T., Kimura, M. and Takahama, U. (1996). Effects of pH and thiocyanate on hydrogen peroxide-induced evolution of molecular oxygen in human mixed saliva. Arch. Oral Biol., 41, 911-917.
15. Price, K.R., Bacon, J.R. and Rhodes, M.J.C. (1997). Effect of storage and domestic processing on the content and composition of flavonol glucosides in onion (Allium cepa). J. Agric. Food Chem., 45, 938-942.
16. Rice-Evans, C.A. and Miller, N.J. (1997). Structure-antioxidant activity relationships of flavonoids and isoflavonoids. In "Flavonoids in Health and Disease," ed. by C.A. Rice-Evans & L. Packer, Marcel Dekker, New York, pp. 199-219.
17. Schreier, P. and Miller, E. (1985), Studies on flavonoid degradation by peroxidase: quercetin. Food Chem., 17, 301-317.
18. Sorata, T., Takahama, U. and Kimura, M. (1984). Protective effect of quercetin and rutin on photosensitized lysis of human erythrocytes in the presence of hematoporphyrin. Biochim. Biophys. Acta, 799, 313-317.
19. Takahama, U. and Hirota, S. (2000). Deglucosidation of quercetin glucosides to the aglycone and formation of antifungal agents by peroxidase-dependent oxidation of quercetin on browning of onion scales. Plant Cell Physiol., 41, 1021-1029.
20. Tenovuo, J. (1998). Nonimmimoglobulin defense factors in human saliva. In "Human Saliva. Clinical Chemistry and Microbiology," ed. by J. Tenovuo. CRC Press, Boca Raton, pp. 55-91.
21. Terao, J. and Piskula, M.K. (1997). Flavonoids as inhibitors of lipid peroxidation in membranes. In "Flavonoids in Health and Disease," ed. by C.A. Rice-Evans & L. Packer, Marcel Dekker, New York, pp. 277-293.
22. Thomas, E.L. and Pera, K.A. (1983). Oxygen metabolism of Streptococcus mutans: uptake of oxygen and release of superoxide and hydrogen peroxide. J. Bacteriol., 154, 1235-1244.
23. Tsuji, S., Nakamura, Y., Tonogai, Y., Shibata, T., Uchibori, N., Kawata, M., Kobayashi, T., Suzuki, H., Miyamoto, F. and Ito, Y. (1990). The amounts of hydrogen peroxide contained in agricultural, stockbreeding and aquatic products and their processed foods. Nippon Shokuhin Kogyo Gakkaishi, 37, 111-123 (in Japanese with English summary).
24. Tsushida, T. and Suzuki, M. (1996). Content of flavonol glucosides and some properties of enzymes metabolizing the glucosides in onion. J. Jpn. Soc. Food Sci. Technol., 43, 642-649.
25. Yamamoto, M., Saeki, K. and Utsumi, K. (1991). Isolation of human salivary polymorphonuclear leukocytes and their stimulation-coupled responses. Arch. Biochem. Biophys., 289, 76-82.