Development of a New Indolocarbazole Anticancer Agent (NB-506)

Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry

Volumn 55, Issue 6, 1997, Pages 566-569

  Mitsuru, Ohkubo ^a  

^a BANYU PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Anticancer; Glycosylation; Indolocarbazole; Mitsunobu reaction; Topoisomerase

Indexed keywords

EID: 0009470809     PISSN: 00379980     EISSN: None     Source Type: Journal    
DOI: 10.5059/yukigoseikyokaishi.55.566     Document Type: Article

References (17)

1. (a) S. Omura, Y. Iwai, A. Hirano, A. Nakagawa, J. Awaya, H. Tsutiya, Y. Takahasi, R. Masuya, J. Antibiot., 30, 275 (1977). The absolute configuration of Staurosporine has been disclosed : N. Futano, H. Takayanagi, Y. Konda, Y. Toda, Y. Harigaya, Y. Iwai, S. Omura, Tetrahedron Lett. 35, 1251 (1994);
2. (a) S. Omura, Y. Iwai, A. Hirano, A. Nakagawa, J. Awaya, H. Tsutiya, Y. Takahasi, R. Masuya, J. Antibiot., 30, 275 (1977). The absolute configuration of Staurosporine has been disclosed : N. Futano, H. Takayanagi, Y. Konda, Y. Toda, Y. Harigaya, Y. Iwai, S. Omura, Tetrahedron Lett. 35, 1251 (1994);
3. (b) D.E. Nettleton, T.W. Doyle, B. Krishnan, G. K. Matsumoto, J. Clardy, ibid., 26, 4011 (1985)
4. H. Arakawa, H.T. Iguch, M. Morita, T. Yoshinari, K. Kojiri, H. Suda, A. Okura, S. Nishimura, Cancer Res., 55, 1316 (1995); T. Yoshinari, M. Matsumoto, H. Arakawa, H. Okada, K. Noguchi, H. Suda, A. Okura, S. Nishimura, ibid., 55, 1310 (1995)
5. H. Arakawa, H.T. Iguch, M. Morita, T. Yoshinari, K. Kojiri, H. Suda, A. Okura, S. Nishimura, Cancer Res., 55, 1316 (1995); T. Yoshinari, M. Matsumoto, H. Arakawa, H. Okada, K. Noguchi, H. Suda, A. Okura, S. Nishimura, ibid., 55, 1310 (1995)
6. A.L. Bodley, L.F. Liu, "MECHANISMS OF DRUG RESISTANCE IN NEOPLASTIC CELLS", eds. by P.V. Woolley III, K.D. Tew, Academic Press, Inc., San Diego, 1988, p.277
7. K. Kojiri, H. Kondo, T. Yoshinari, H. Arakawa, S. Nakajima, F. Satoh, K. Kawamura, A. Okura, H. Suda, M. Okanishi, J. Antibiot., 44, 723 (1991)
8. (a) S. Tanaka, M. Ohkubo, K. Kojiri, H. Suda, A. Yamada, D. Uemura, J. Antibiot., 45, 1797 (1992);
9. (b) T. Yoshinari, A. Yamada, D. Uemura, K. Nomura, H. Arakawa, K. Kojiri, E. Yoshida, A. Okura, Cancer Res., 53, 490 (1993); H. Arakawa, T. Iguchi, T. Yoshinari, K. Kojiri, H. Suda, A. Okura, ibid., 84, 574 (1993)
10. (b) T. Yoshinari, A. Yamada, D. Uemura, K. Nomura, H. Arakawa, K. Kojiri, E. Yoshida, A. Okura, Cancer Res., 53, 490 (1993); H. Arakawa, T. Iguchi, T. Yoshinari, K. Kojiri, H. Suda, A. Okura, ibid., 84, 574 (1993)
11. F. Seela, H-D. Winkeler, J. Org. Chem., 47, 226 (1982); F. Seela, B. Westermann, U. Bindig, J. Chem. Soc. Perkin Trans. I, 1998, 697; F. Seela, W. Bourgeois, Synthesis, 1990, 945
12. F. Seela, H-D. Winkeler, J. Org. Chem., 47, 226 (1982); F. Seela, B. Westermann, U. Bindig, J. Chem. Soc. Perkin Trans. I, 1998, 697; F. Seela, W. Bourgeois, Synthesis, 1990, 945
13. F. Seela, H-D. Winkeler, J. Org. Chem., 47, 226 (1982); F. Seela, B. Westermann, U. Bindig, J. Chem. Soc. Perkin Trans. I, 1998, 697; F. Seela, W. Bourgeois, Synthesis, 1990, 945
14. M. Ohkubo, H. Kawamoto, T. Ohno, M. Nakano, H. Morishima, Tetrahedron, "Synthesis of NB-506, A New Anticancer Agent"
15. M. Brenner, H. Rexhausen, B. Steffan, W. Steglich, Tetrahedron, 44, 2887 (1988)
16. M. Ohkubo, T. Nishimura, H. Jona, T. Honma, H. Morishima, Tetrahedron, 52, 8099 (1996)
17. M. Ohkubo, T. Nishimura, H. Jona, T. Honma, S. Ito, H. Morishima, Tetrahedron, "Synthesis of Dissymmetric Indolocarbazole Glycosides Using the Mitsunobu Reaction at the Glycosylation Step",