Current trends in the management of acute respiratory distress syndrome

Current Opinion in Critical Care

Volumn 5, Issue 1, 1999, Pages 1-8

  Suntharalingam, Ganesh ^a   Evans, Timothy W ^a  

^a ROYAL BROMPTON HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0009465735     PISSN: 10705295     EISSN: None     Source Type: Journal    
DOI: 10.1097/00075198-199902000-00001     Document Type: Article

References (53)

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29. 2O) to below currently accepted limits does not produce outcome benefits in patients with risk factors for ARDS. Protective maneuvers consist of passive limitation of ventilatory parameters rather than active recruitment and stabilization of lung, and so the hypothesis tested may be weaker than in other recent work.
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43. 2 and so minimize intensity of ventilation in patients on inhaled nitric oxide; positive findings would have implied a mechanism of therapeutic benefit by reducing risk of ventilator-induced lung injury. In fact differences between oxygenation between groups were abolished within 72 hrs, possibly due to protective-ventilation strategy applied to both groups.
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50. Meduri GU, Chinn AJ, Leeper KV, Wunderink RG, Tolley E, Winer-Muram HT, et al.: Corticosteroid rescue treatment of progressive fibroproliferation in late ARDS. Patterns of response and predictors of outcome. Chest 1994, 105:1516-1527.
51. Meduri GU, Headley AS, Golden E, Carson SJ, Umberger RA, Kelso T, Tolley EA: Effect of prolonged methylprednisolone therapy in unresolving acute respiratory distress syndrome. JAMA 1998, 280:159-165. This blinded, randomized, controlled trial (n = 24) shows marked differences in ICU and hospital outcome between B patients receiving placebo and 16 patients treated with methylprednisolone starting at 2 mg/kg daily at an early stage (after at least 7 days of mechanical ventilation), continuing up to 32 days. Outcome appeared to be significantly improved in the treatment group, with no significant increase in infection.
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