The gut: The "motor" of multiple organ dysfunction syndrome?

Current Opinion in Critical Care

Volumn 5, Issue 2, 1999, Pages 126-131

  Nieuwenhuijzen, Grard A P ^a   Goris, R Jan A ^b  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0008539152     PISSN: 10705295     EISSN: None     Source Type: Journal    
DOI: 10.1097/00075198-199904000-00006     Document Type: Article

References (79)

1. Meakins JL, Marshall JC: The gastro-intestinal tract: the "motor" of multiple organ failure. Arch Surg 1986, 121:197-201. A classic article on the hypothesis that bacterial translocation could be the driving force of multiple organ dysfunction syndrome. It has caused a vivid discussion on the pathophysiology of multiple organ dysfunction syndrome.
2. Marshall JC, Christou NV, Meakins JL: The gastrointestinal tract. The "undrained abscess" of multiple organ failure. Ann Surg 1993, 218:111-119.
3. Goris RJA, Boekholtz WKF, van Bebber IPT, Nuytinck JKS, Schillings PHM: Multiple-organ failure and sepsis without bacteria. Arch Surg 1986, 121:897-901.
4. Goris RJA, te Boekhorst TPA, Nuytinck JKS, Gimbrere JSF: Multiple organ failure: generalized autodestructive inflammation? Arch Surg 1985, 120:1109-1115. The first article to introduce the hypothesis that nonbacterial generalized inflammatory response could cause multiple organ dysfunction syndrome. It initiated extensive reserch on the role of inflammatory mediators in multiple organ dysfunction syndrome.
5. Donowitz LG, Wenzel RP, Hoyt JW: High risk of hospital-acquired infection in the ICU patient. Crit Care Med 1982, 10:355-357.
6. Bartlett JG, O'Keefe P, Tally FP, Louie TJ, Gorbach SL: Bacteriology of hospital-acquired pneumonia. Arch Intern Med 1986, 146:868-871.
7. Emmerson AM: The epidemiology of infections in intensive care units. Intensive Care Med 1990, 16(suppl):S197-S200.
8. Nathens AB, Chu PTY, Marshall JC: Nosocomial infection in the surgical intensive care unit. Infect Dis Clin North Am 1992, 6:657-675. A good review on various aspects of nosocomial infections in the intensive care unit.
9. Craven DE, Kunches LM, Lichtenberg DA, Kollisch NR, Barry A, Heeren TC, et al.: Nosocomial infections and fatality in medical and surgical intensive care unit patients. Arch Intern Med 1988, 148:1161-1168.
10. Girou E, Stephan F, Novara A, Safar M, Fagon JY: Risk factors and outcome of nosocomial infections: results of a matched case-control study of ICU patients. Am J Respir Crit Care Med 1998, 157:1151-1158.
11. Gross PA, Neu HC, Aswapokee P, van Antwerpen C, Aswapokee N: Deaths from nososcomial infections: experience in a university hospital and a community hospital. Am J Med 1980, 68:219-223.
12. Craven DE, Steger KA, Barat LM, Duncan RA: Nococomial pneumonia: epidemiology and infection control. Intensive Care Med 1992, 18(suppl):S3-S9.
13. Selective Decontamination of the Digestive Tract Triallists' Collaborative Group: Meta-analysis of randomised controlled trials of selective decontamination of the digestive tract. Br Med J 1993, 307:525-532.
14. Fagon J-Y, Chastre J, Domart Y, Trouillet J-L, Pierre J, Darne C, et al.: Nosocomial pneumonia in patients receiving continuous mechanical ventilation. Am Rev Respir Dis 1989, 139:877-884.
15. Freeman J, Rosner BA, McGowan JE: Adverse effects of nosocomial infection. J Infect Dis 1979, 140:732-740.
16. Chevret S, Hemmer M, Carlet J, Langer M, European Cooperative Group on Nosocomial Pneumonia: Incidence and risk factors of pneumonia acquired in intensive care units. Intensive Care Med 1993, 19:256-264.
17. Rello J, Rue M, Jubert P, Muses G, Sonora R, Valles J, et al.: Survival in patients with nosocomial pneumonia: impact of the severity of illness and the etiological agent. Crit Care Med 1997, 25:1862-1867.
18. Leu HS, Kaiser DL, Mori M, Woolson RF, Wenzel RP: Hospital-acquired pneumonia: attributable mortality and morbidity. Am J Epidemiol 1989, 129:1258-1267.
19. Craven DE, Kunches LM, Kilinsky V, Lichtenberg DA, Make BJ, McCabe WR: Risk factors for pneumonia and fatality in patients receiving continuous mechanical ventilation. Am Rev Respir Dis 1986, 133:792-796.
20. Le Frock JL, Ellis CA, Weinstein L: The relation between aerobic fecal and oropharyngeal microflora in hospitalized patients. Am J Med Sci 1979, 277:701-706.
21. Kerver AJH, Rommes JH, Mevissen-Verhage EAE, Hulstaert PF, Vos A, Verhoef J, et al.: Colonisation and infection in surgical intensive care patients-a prospective study. Intensive Care Med 1987, 13:347-351.
22. Atherton ST, White DJ: Stomach as source of bacteria colonising respiratory tract during artificial ventilation. Lancet 1978, 2:968-969.
23. Polk HCJ, Shields CL: Remote organ failure: a valid sign of occult intra-abdominal infection. Surgery 1977, 81:310-313.
24. Fry DE, Pearlstein L, Fulton RL, Jr HCP: Multiple system organ failure. The role of uncontrolled infection. Arch Surg 1980, 115:136-140.
25. Marshall JC, Christou NV, Horn R, Meakins JL: The microbiology of multiple organ failure. The proximal gastrointestinal tract as an occult reservoir of pathogens. Arch Surg 1988, 123:309-315.
26. Waydhas C, Nast-Kolb D, Jochum M, Trupka A, Lenz S, Fritz H, et al.: Inflammatory mediators, infection, sepsis, and multiple organ failure after severe trauma. Arch Surg 1992, 127:460-467.
27. Norton LW: Does drainage of intraabdomial pus reverse multiple organ failure? Am J Surg 1985, 149:347-350.
28. Marshall JC, Sweeney D: Microbial infection and the septic response in critical surgical illness, sepsis, not infection determines outome. Arch Surg 1990, 125:17-23.
29. van der Waaij D, Berghuis-de Vries JM, Lekkerkerk-van der Wees JEC: Colonization resistance of the digestive tract in conventional and antibiotic treated mice. J Hygiene (Cambridge) 1971, 69:405-411.
30. D'Amico R, Pifferi S, Leonetti C, Torri V, Tinazzi A, Liberati A: Effectiveness of antibiotic prophylaxis in critically ill adult patients: systematic review of randomised controlled trials. Br Med J 1998, 316:1275-1285. A recent meta-analysis and review of trials with selective decontamination of the digestive tract in critically ill patients is presented.
31. Heyland DK, Cook DJ, Jaeschke R, Griffith L, Lee HN, Guyat GH: Selective decontamination of the digestive tract: an overview. Chest 1994, 105:1221-1229.
32. Hurley JC: Prophylaxis with enteral antibiotics in ventilated patients: selective decontamination or selective cross-infection? Antimicrob Agents 1995, 39:941-947.
33. Kollef MH: The role of selective digestive tract decontamination on mortality and respiratory tract infections, a meta-analysis. Chest 1994, 105:1101-1108.
34. Vandenbroucke-Grauls C, Vandenbroucke J: Effect of selective decontamination of the digestive tract on respiratory infections and mortality in the intensive care unit. Lancet 1991, 338:859-862.
35. Goris RJA, van Bebber IPT, Mollen RMH, Koopman JP: Does selective decontamination of the gastrointestinal tract prevent multiple organ failure? Arch Surg 1991, 126:561-565.
36. Rosman C, Wübbels GH, Manson WL, Bleichrodt RP: Selective decontamination of the digestive tract prevents secondary infection of the abdominal cavity, and endotoxemia and mortality in sterile peritonitis in laboratory rats. Crit Care Med 1992, 20:1699-1704.
37. Sorkine P, Szold O, Halpem P, Gutman M, Greemland M, Rudnick V, et al.: Gut decontamination reduces bowel ischaemia-induced lung injury in rats. Chest 1997, 112:491-495.
38. Berg RD, Garlington AW: Translocation of certain indigenous bacteria from the gastrointestinal tract to the mesenteric lymph nodes and other organs in a gnotobiotic mouse model. Infect Immun 1979, 23:403-411.
39. Flanagan Jr JJ, Rush Jr BF, Murphy TF, Smith S, Machiedo GW, Hsieh J, et al.: A "treated" model for severe hemorrhagic shock: a comparison of conventional and germ-free animals. Am J Med 1990, 21:104-120.
40. Maejima K, Deitch EA, Berg RD: Bacterial translocation from the gastrointestinal tracts of rats receiving thermal injury. Infect Immun 1984, 43:6-10.
41. Salman FT, Buyruk MN, Gurler N, Celik A: The effect of surgical trauma on the bacterial translocation from the gut. J Pediatr Surg 1992, 27:802-804.
42. Deitch EA, Bridges WM, Ma JW, Ma L, Berg RD: Obstructed intestine as a reservoir for systemic infection. Am J Surg 1990, 159:394-401.
43. Deitch EA, Sittig K, Li M, Berg R, Specian RD: Obstructive jaundice promotes bacterial translocation from the gut. Am J Surg 1990, 159:79-84.
44. Deitch EA, Ma WJ, Ma L, Berg RD, Specian RD: Endotoxin-induced bacterial translocation: a study of mechanisms. Surgery 1989, 106:292-300.
45. Mainous MR, Xu DZ, Deitch EA: Role of xanthine oxidase and prostaglandins in inflammatory-induced bacterial translocation. Circ Shock 1993, 40:99-104.
46. Mainous M, Tso P, Berg RD, Deitch EA: Studies of the route, magnitude, and time course of bacterial translocation in a model of systemic inflammation. Arch Surg 1991, 126:33-37.
47. Deitch EA, Specian RD, Grisham MB, Berg RD: Zymosan-induced bacterial translocation: A study of mechanisms. Crit Care Med 1992, 20:782-788.
48. Deitch EA, Kemper AC, Specian RD, Berg RD: A study of the relationships among survival, gut-origin sepsis, and bacterial translocation in a model of systemic inflammation. J Trauma 1992, 32:141-147. An experimental study describing the possible relationship between bacterial translocation and multiple organ dysfunction syndrome.
49. Marshall JC, Christou NV, Meakins JL: Immunomodulation by altered gastrointestinal tract flora. Arch Surg 1988, 123:1465-1469.
50. Deitch EA, Xu D, Qi L, Berg RD: Bacterial translocation from the gut impairs systemic immunity. Surgery 1991, 109:269-276.
51. Nieuwenhuijzen GAP, Haskel Y, Lu Q, Berg RD, van Roojen N, Goris RJA, et al.: Macrophage elimination increases bacterial translocation and gut-origin septicemia but attenuates symptoms and mortality rate in a model of systemic inflammation. Ann Surg 1993, 218:791-799. An experimental study that disassociates the effects of the systemic spread of bacteria and a generalized inflammatory response on the development of multiple organ dysfunction syndrome.
52. Sori AJ, Rush Jr BF, Lysz TW, Smith S, Machiedo GW: The gut as source of sepsis after hemorrhagic shock. Am J Surg 1988, 155:187-192.
53. LeVoyer T, Cioffi WG, Pratt L: Alterations in intestinal permeability after thermal injury. Arch Surg 1992, 127:26-30.
54. Ziegler TR, Smith RJ, O'Dwyer ST, Demling RH, Wilmore DW: Increased intestinal permeability associated with infection in burn patients. Arch Surg 1988, 123:1313-1319.
55. Deitch EA: Intestinal permeability is increased in burn patients shortly after injury. Surgery 1990, 107:411-416.
56. Roumen RMH, Hendriks T, Wevers RA, Goris RJA: Intestinal permeability after severe trauma and hemorrhagic shock is increased without relation to septic complications. Arch Surg 1993, 128:453-457.
57. Doig CJ, Suckerland LR, Sandham JD, Fick GH, Verhoef M, Meddings JB: Increased intestinal permeability is associated with the development of multiple orgam dysfunction sysndrome in critically ill ICU patients. Am J Respir Crit Care Med 1998, 158:444-451.
58. Winchurch RA, Thupari JN, Munster AM: Endotoxemia in burn patients: levels of circulating endotoxins are related to burn size. Surgery 1987, 102:808-812.
59. Munster AM, Smith-Creek M, Dickerson C, Winchurch RA: Translocation, Incidental phenomenon or true pathology? Ann Surg 1993, 218:321-327.
60. Ziegler EJ, Fischer Jr CJ, Sprung CL, Straube RC, Sadoff JC, Foulke GE, et al.: Treatment of Gram-negative bacteremia and septic shock with HA-1A human monoclonal antibody against endotoxin. A randomized, double blind, placebo-controlled trial. The HA-1A Sepsis Study Group. N Engl J Med 1991, 324:429-436.
61. Ambrose NS, Johnson M, Surdon DW, Keighley MRB: Incidence of pathogenic bacteria from mesenteric lyph nodes and ileal serosa during Crohn's disease surgery. Br J Surg 1984, 71:623-625.
62. Deitch EA: Simple intestinal obstruction causes bacterial translocation in man. Arch Surg 1989, 124:699-701.
63. Moore FA, Moore EE, Poggetti R, McAnena OJ, Peterson VM, Abernathy CM, et al.: Gut bacterial translocation via the portal vein: a clinical perspective with major torso trauma. J Trauma 1991, 31:629-638. A unique human study with catheters placed in the portal vein examines gut origin factors via the portal route that could initiate the development of multiple organ dysfunction syndrome.
64. Brathwaite CE, Ross SE, Nagele R, Mure AJ, O'Malley KF, Garcia-Perez FA: Bacterial translocation occurs in humans after traumatic injury: evidence using immunofluorescence. J Trauma 1993, 34:586-590.
65. Reed LL, Martin M, Manglano R, Newson B, Kocka F, Barret J: Bacterial translocation following abdominal trauma in humans. Circ Shock 1994, 42:1-6.
66. Kane TD, Alexander JW, Johannigman JA: The detection of microbial DNA in the blood. Ann Surg 1998, 227:1-9.
67. Peitzman AB, Udekwu AO, Ochoa J, Smith S: Bacterial translocation in trauma patients. J Trauma 1991, 31:1083-1087.
68. van Goor H, Rosman C, Grond J, Kooi K, Wübbels GH, Bleichrodt RP: Translocation of bacteria and endotoxin in organ donors. Arch Surg 1994, 129:1063-1066.
69. Deitch EA: Multiple organ failure: Pathophysiology and potential future therapy. Ann Surg 1992, 216:117-134. An outstanding review on pathophysiological aspects of multiple organ dysfunction syndrome is presented.
70. Lemaire LCJM, van Lanschot JJB, Stoutenbeek CP, van Deventer SJH, Wells CL, Gouma DJ: Bacterial translocation in multiplke organ failure: cause or epiphenomenon still unproven. Br J Surg 1997, 84:1340-1350. A recent review on experimental and clinical evidence of bacterial translocation and its relationship with the development of multiple organ dysfunction syndrome is presented.
71. Alexander JW, Boyce ST, Babcock GF, Gianotti L, Peck MD, Dunn DL, et al.: The process of microbial translocation. Ann Surg 1990, 212:496-512.
72. Wells CL, Jechorek RP, Erlandsen SL: Evidence for the translocation of enterococcus faecalis across the mouse intestinal tract. J Infect Dis 1990, 162:82-90.
73. Mainous MR, Ertel W, Chaudry IH, Deitch EA: The gut: a cytokine generating organ in systemic inflammation? Shock 1995, 4:193-199.
74. Deitch EA, Xu D, Franko L, Ayala A, Chaudry IH: Evidence favoring the role of the gut as a cytokine-generating organ in rats subjected to hemorrhagic shock. Shock 1994, 1:141-146.
75. Magnotti LJ, Upperman JS, Xu D, Lu Q, Deitch EA: Gut-derived mesenteric lymph but not portal blood increases endothelial cell permeability and promotes lung injury after hemorrhagic shock. Ann Surg 1998, 228:518-527. An elegant experimental study describes the gut as a source of inflammatory mediators, which could contribute to distant organ failure. This study could initiate a new direction in future research on the role of the gut in multiple organ dysfunction syndrome.
76. Gerkin TM, Oldham KT, Guice KS, Hinshaw DB, Ryan US: Intestinal ischemia-reperfusion injury causes pulmonary endothelial cell ATP depletion. Ann Surg 1993, 217:48-56.
77. Pogetti RS, Moore FA, Moore EE, Koeike K, Banerjee A: Simultaneous liver and lung injury following gut ischemia is mediated by xanthine oxidase. J Trauma 1992, 32:723-728.
78. Schmeling DJ, Caty MG, Oldham KT, Guice KS, Hinshaw DB: Evidence for neutrophil-related acute lung injury after intestinal ischemia-reperfusion. Surgery 1989, 106:195-202.
79. Lemaire LCJM: The thoracic duct in patients with multiple organ failure: no major route of bacterial translocation. In: Immunological aspects of thoracic duct lymph in patients with and without multiple organ failure [doctoral thesis]. University of Amsterdam, The Netherlands, 1998. This recent thesis describes unique studies on the lymphatic route of bacterial translocation in patients devloping multiple organ dysfunction syndrome.