Iron Regulatory Proteins, Iron Responsive Elements and Iron Homeostasis

Journal of Nutrition

Volumn 130, Issue 1 SUPPL., 2000, Pages 2295-2298

  Eisenstein, Richard S ^a   Blemings, Kenneth P ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Ferritin; Iron; Iron regulatory protein; Iron responsive element; Transferrin receptor

Indexed keywords

EID: 0006920842     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Bettany, A.J.E., Eisenstein, R. S. & Munro, H. N. (1992) Mutagenesis of the IRE-BP further defines a role for RNA secondary structure in the regulation of ferritin and TfR expression. J. Biol. Chem. 267: 16531-16537.
2. Bouton, C., Oliveira, L. & Drapier, J. C. (1998) Converse modulation of IRP1 and IRP2 by immunological stimuli in murine RAW 264.7 macrophages. J. Biol. Chem. 273: 9403-9408.
3. Brown, N. M., Anderson, S. A., Steffen, D. W., Carpenter, T. B., Kennedy, M. C., Walden, W. E. & Eisenstein, R. S. Novel role of phosphorylation in Fe-S cluster stability revealed by phosphomimetic mutations at Ser 138 of IRP 1. Proc. Natl. Acad. Sci. U.S.A. (in press).
4. Chen, O. S., Blemings, K. P., Schalinske, K. L. & Eisenstein, R. S. (1998) Dietary iron intake rapidly influences IRPs, ferritin subunits and mitochondrial aconitase in rat liver. J. Nutr. 128: 525-535.
5. Chen, O. S., Schalinske, K. L. & Eisenstein, R. S. (1997) Dietary iron intake modulates the activity of IRPs and the abundance of ferritin and mitochondrial aconitase in rat liver. J. Nutr. 127: 238-248.
6. Eisenstein, R. S., Kennedy, M. C. & Beinert, H. (1997) The IRE, the IRP and cytosolic aconitase: posttranscriptional regulation of mammalian iron metabolism. In: Metal Ions and Gene Regulation (Silver, S. and Walden, W., eds.), pp. 157-216. Chapman and Hall, New York, NY.
7. Fleming, M. D., III, C. C. T., Su, M. A., Foernzler, D., Bier, D. R., Dietrich, W. F. & Andrews, N. C. (1997) Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene. Nature Genet. 16: 383-386.
8. Fleming, M. D., Romano, M. A., Su, M. A., Garrick, L. M., Garrick, M. D. & Andrews, N. C. (1998) Nramp2 is mutated in the anemic Belgrade (b) rat. Proc. Natl. Acad. Sci. (U.S.A.) 95: 1148-1153.
9. 2· -. J. Biol. Chem. 268: 22369-22376.
10. 2· -driven aconitase Fe-S center cycling. Biosci. Reports 17: 33-42.
11. Gdaniec, Z., Sierzputowska-Gracz, H. & Theil, E. C. (1998) IREs and internal loop/bulge structure for ferritin mRNA studied by cobalt(III) hexammine binding, molecular modeling, and NMR spectroscopy. Biochem. 37: 1505-1512.
12. Gray, N. K., Pantopoulos, K., Dandekar, T., Ackrell, B. & Hentze, M. W. (1996) Translational regulation of mammalian and drosophila citric acid cycle enzymes via IREs. Proc. Natl. Acad. Sci. (U.S.A.) 93: 4925-4930.
13. Gunshin, H., Mackenzie, B., Berger, U. V., Gunshin, Y., Romero, M. F., Boron, W. F., Nussberger, S., Gollan, J. L. & Hediger, M. A. (1997) Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature 388: 482-488.
14. Gutierrez, J. A., Yu, J., Rivera, S. & Wessling-Resnick, M. (1997) Functional expression cloning and characterization of SFT, a stimulator of Fe transport. J. Cell Biol. 139: 895-905.
15. Hanson, E. S. & Leibold, E. A. (1998) Regulation of IRP1 during hypoxia and hypoxia/reoxygenation. J. Biol. Chem 273: 7588-7593.
16. Hentze, M. W. & Kuhn, L. C. (1996) Molecular control of vertebrate iron metabolism: mRNA-based circuits operated by iron, nitric oxide, and oxidative stress. Proc. Natl. Acad. Sci. (U.S.A.) 93: 8175-8182.
17. Iwai, K., Drake, S. K., Wehr, N. B., Weissman, A. M., LaVaute, T., Minato, N., Klausner, R. D., Levine, R. L. & Rouault, T. A. (1998) Iron-dependent oxidation, ubiquitination, and degradation of IRP2. Proc. Natl. Acad. Sci. (U.S.A.) 95: 4924-4928.
18. Ke, Y., Wu, J., Leibold, E. A., Walden, W. E. & Theil, E. C. (1998) Loops and bulge/ loops in IRE isoforms influence IRP binding. J. Biol. Chem 273: 23637-23640.
19. Kennedy, M. C., Antholine, W. E. & Beinert, H. (1997) An EPR investigation of the products of the reaction of cytosolic and mitochondrial aconitases with nitric oxide. J. Biol. Chem. 272: 20340-20347.
20. Kim, H.Y., LaVaute, T., Iwai, K., Klausner, R. D. & Rouault, T. A. (1996) Identification of a conserved and functional IRE in the 5′-untranslated region of mammalian mitochondrial aconitase. J. Biol. Chem 271: 24226-24230.
21. Lee, P. L., Gelbart, T., West, C., Halloran, C. & Beutler, E. (1998) The human Nramp2 gene. Blood Cells Mol. Dis. 24: 199-215.
22. 2) control mammalian iron metabolism by different pathways. Mol. Cell. Biol. 16: 3781-3788.
23. Rouault, T. A. & Klausner, R. D. (1996) Post-transcriptional regulation of genes of iron metabolism in mammalian cells. J. Biol. Inorg. Chem. 1: 494-499.
24. Schalinske, K. L. & Eisenstein, R. S. (1996) Phosphorylation and activation of both IRP1 and IRP2 in HL60 cells. J. Biol. Chem 271: 7168-7176.
25. Schalinske, K. L., Anderson, S. A., Tuazon, P. T., Chen, O. S. & Eisenstein, R. S. (1997) The iron-sulfur cluster of IRP1 modulates accessibility of RNA binding and phosphorylation sites. Biochem. 36: 3950-3958.
26. Schalinske, K. L., Chen, O. S. & Eisenstein, R. S. (1998) Iron differentially stimulates translation of mitochondrial aconitase and ferritin mRNAs in mammalian cells. J. Biol. Chem 273: 3740-3746.
27. Theil, E. C. (1994) IREs:a family of mRNA non-coding sequences. Biochem. J. 304: 1-11.