Neuregulins as potential drugs for neurological disorders

Cold Spring Harbor Symposia on Quantitative Biology

Volumn 61, Issue , 1996, Pages 459-472

  Marchionni, M A ^a   Kirk, C J ^a   Isaacs, I J ^a   Hoban, C J ^a   Mahanthappa, N K ^a   Anton, E S ^b   Chen, C ^a   Wason, F ^a   Lawson, D ^a   Hamers, F P T ^c   Canoll, P D ^d   Reynolds, R ^e   Cannella, B ^f   Meun, D ^a   Holt, W F ^a   Matthew, W D ^b   Chen, L E ^b   Gispen, W H ^c   Raine, C S ^f   Salzer, J L ^d   Gwynne, D I ^a   more..

^a CeNeS Pharmaceuticals plc   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c UTRECHT UNIVERSITY   (Netherlands)

^d NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

^f ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NEU DIFFERENTIATION FACTOR; CIMAGLERMIN ALFA;

CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; CONFERENCE PAPER; NERVE CELL; NEUROLOGIC DISEASE; NONHUMAN; PRIORITY JOURNAL; SCHWANN CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL FUNCTION; CELL MIGRATION; CHO CELL LINE; COLUMN CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MOTOR PERFORMANCE; NEURITE OUTGROWTH; OLIGODENDROCYTE PROGENITOR; OLIGODENDROGLIA; PERIPHERAL NERVE INJURY; PERIPHERAL NEUROPATHY; RAT; SCIATIC NERVE;

EID: 0005696271     PISSN: 00917451     EISSN: None     Source Type: Book Series    
DOI: 10.1101/sqb.1996.061.01.048     Document Type: Conference Paper

References (64)

1. Apfel, S.C. and J.A. Kessler. 1996. Neurotrophic factors in the treatment of peripheral neuropathy. CIBA Found. Symp. 196: 98.
2. Barbacid, M. 1994. The trk family of neurotrophin receptors. J. Neurobiol. 25: 386.
3. Barres, B.A., I.K. Hart, H.S.R. Coles, J.F. Burne, J.T. Voyvodic, W.D. Richardson, and M.C. Raff. 1992. Cell death and control of cell survival in the oligodendrocyte lineage. Cell 70: 31.
4. Bermingham-McDonogh, O., K.L. McCabe, and T.A. Reh. 1996. Effects of GGF/neuregulins on neuronal survival and neurite outgrowth correlate with erbB2/neu expression in developing rat retina. Development 122: 1427.
5. Brockes, J.P., G.E. Lemke, and D.R. Balzer, Jr. 1980. Purification and preliminary characterization of a glial growth factor from the bovine pituitary. J. Biol. Chem. 255: 8374.
6. Bunge, R.P. 1994. The role of the Schwann cell in trophic support and regeneration. J. Neurol. 241: 19.
7. Canoll, P.D., J.M. Musacchio, R. Hardy, R. Reynolds, M.A. Marchionni, and J.L. Salzer. 1996. GGF/neuregulin is a neuronal signal that promotes the proliferation and survival and inhibits the differentiation of oligodendrocyte progenitors. Neuron 17: 229.
8. Carraway, K.L. and S.J. Burden. 1995. Neuregulins and their receptors. Curr. Opin. Neurobiol. 5: 606.
9. Chen, L.E., A.V. Seaber, and J.R. Urbaniak. 1993. The influence of magnitude and duration of crush load on functional recovery of the peripheral nerve. J. Reconstruct. Microsurg. 9: 299.
10. Chen, M.S., O. Bermingham-McDonogh, F. Danehy, Jr., C. Nolan, S.S. Scherer, J. Lucas, D. Gwynne, and M.A. Marchionni. 1994. Expression of multiple neuregulin transcripts in postnatal rat brains. J. Comp. Neurol. 349: 389.
11. Cheng, L. and A.W. Mudge. 1996. Cultured Schwann cells constitutively express the myelin protein P0. Neuron 16: 309.
12. Chu, G.C., L.M. Moscoso, M.X. Sliwkowski, and J.P. Merlie. 1995. Regulation of the acetylcholine receptor epsilon subunit gene by recombinant ARIA: An in vitro model for transynaptic gene regulation. Neuron 14: 329.
13. Corfas, G., D.L. Falls, and G.D. Fischbach. 1993. ARIA, a protein that stimulates acetylcholine receptor synthesis, also induces tyrosine phosphorylation of a 185-kDa muscle transmembrane protein. Proc. Natl. Acad. Sci. 90: 1624.
14. Corfas, G., K.M. Rosen, H. Aratake, R. Krauss, and G.D. Fischbach. 1995. Differential expression of ARIA isoforms in the rat brain. Neuron 14: 103.
15. Dong, Z., A. Brennan, N. Liu, Y. Yarden, G. Lefkowitz, R. Mirsky, and K.R. Jessen. 1995. Neu differentiation factor is a neuron-glia signal and regulates survival, proliferation, and maturation of rat Schwann cell precursors. Neuron 15: 585.
16. Falls, D.L., K.M. Rosen, G. Corfas, W.S. Lane, and G.D. Fischbach. 1993. ARIA, a protein that stimulates acetylcholine receptor synthesis, is a member of the neu ligand family. Cell 72: 801.
17. Funakoshi, H., J. Frisen, G. Barbany, T. Timmusk, O. Zachrisson, V.M.K. Verge, and H. Persson. 1993. Differential expression of mRNAs for neurotrophins and their receptors after axotomy of the sciatic nerve. J. Cell Biol. 123: 455.
18. Gassmann, M., F. Casagranda, D. Orioli, H. Simon, C. Lai, R. Klein, and G. Lemke. 1995. Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor. Nature 378: 390.
19. Gerritsen Van der Hoop, R., P. De Koning, E. Boven, J.P. Neijt, F.G.I. Jennekens, and W.H. Gispen. 1988. Efficacy of the neuropeptide ORG.2766 in the prevention and treatment of cisplatin-induced neurotoxicity in rats. Eur. J. Cancer Clin. Oncol. 24: 637.
20. Goodearl, A.D., J.B. Davis, K. Mistry, L. Minghetti, M. Otsu, M.D. Waterfield, and P. Stroobant. 1993. Purification of multiple forms of glial growth factor. J. Biol. Chem. 268: 18095.
21. Grinspan, J. B., M.A. Marchionni, M. Reeves, M. Coulaloglou, and S.S. Scherer 1996. Axonal interactions regulate Schwann cell apoptosis in developing peripheral nerve: Neuregulin receptors and the role of neuregulins. J. Neurosci. (in press).
22. Guenard, V., N. Kleitman, T.K. Morrissey, R.P. Bunge, and P. Aebischer. 1992. Syngeneic Schwann cells derived from adult nerves seeded in semipermeable guidance channels enhance peripheral nerve regeneration. J. Neurosci. 12: 3310.
23. -) oligodendroglial progenitors. J. Neurosci. Res. 34: 589.
24. Hefti, F. 1994. Neurotrophic factor therapy for nervous system degenerative diseases. J. Neurobiol. 25: 1418.
25. Henderson, C.E., H.S. Phillips, R.A. Pollock, A.M. Davies, C. Lemeulle, M. Armanini, L.C. Simpson, B. Moffet, R.A. Vandlen, V.E. Koliatsos, and A. Rosenthal. 1994. GDNF: A potent survival factor for motoneurons present in peripheral nerve and muscle. Science 266: 1062.
26. Ho, W.H., M.P. Armanini, A. Nuijens, H.S. Phillips, and P.L. Osheroff. 1995. Sensory and motor neuron-derived factor: A novel heregulin variant highly expressed in sensory and motor neurons. J. Biol. Chem. 270: 14523.
27. erbB2. Science 256: 1205.
28. Ikeda, K., B. Klinkosz, T. Greene, J.M. Cedarbaum, V. Wong, R.M. Lindsay, and H. Mitsumoto. 1995. Effects of brain-derived neurotrophic factor on motor dysfunction in wobbler motor neuron disease. Ann. Neurol. 37: 505.
29. Jessell, T.M., R.E. Siegel, and G.D. Fischbach. 1979. Induction of acetylcholine receptors on cultured skeletal muscle by a factor extracted from brain and spinal cord. Proc. Natl. Acad. Sci. 76: 5397.
30. Jessen, K.R. and R. Mirsky. 1991. Schwann cell precursors and their development. Glia 4: 185.
31. Jo, S.A., X. Zhu, M.A. Marchionni, and S.J. Burden. 1995. Neuregulins are concentrated at nerve-muscle synapses and activate ACh receptor gene expression. Nature 373: 158.
32. 125I-rhGGF2. Soc. Neurosci. Abstr. 21: 314.
33. Kraus, M.H., W. Issing, T. Miki, N.C. Popescu, and S.A. Aaronson. 1989. Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: Evidence for overexpression in a subset of human mammary tumors. Proc. Natl. Acad. Sci. 86: 9193.
34. Lai, C. and G. Lemke 1991. An extended family of protein-tyrosine kinase genes differentially expressed in the vertebrate nervous system. Neuron 6: 691.
35. Lee, K.F., H. Simon, H. Chen, B. Bates, M.C. Hung, and C. Hauser. 1995. Requirement for neuregulin receptor erbB2 in neural and cardiac development. Nature 378: 394.
36. Lemke, G. 1996. Neuregulins in development. Mol. Cell. Neurosci. 7: 247.
37. Lemke, G.E. and J.P. Brockes. 1984. Identification and purification of glial growth factor. J. Neurosci. 4: 75.
38. Levi, A.D.O., R.P. Bunge, J.A. Lofgren, L. Meima, F. Hefti, K. Nikolics, and M.X. Sliwkowski 1995. The influence of heregulins on human Schwann cell proliferation. J. Neurosci. 14: 1329.
39. Li, L., R.W. Oppenheim, M. Lei, and L.J. Houenou. 1994. Neurotrophic agents prevent motoneuron death following sciatic nerve section in the neonatal mouse. J. Neurobiol. 25: 759.
40. Lindsay, R.M. 1996. Therapeutic potential of the neurotrophins and neurotrophin-CNTF combinations in peripheral neuropathies and motor neuron diseases. CIBA Found. Symp. 196: 39.
41. Louis, J.C., E. Magal, D. Muir, M. Manthorpe, and S. Varon. 1992. CG-4, a new bipotential glial cell line from rat brain, is capable of differentiating in vitro into either mature oligodendrocytes or type-2 astrocytes. J. Neurosci. Res. 31: 193.
42. Mahanthappa, N.K., E.S. Anton, and W.D. Mathew. 1996. Glial growth factor 2, a soluble neuregulin, directly increases Schwann cell motility and indirectly promotes neurite outgrowth. J. Neurosci. 16: 4673.
43. Marchionni, M.A. 1995. Cell-cell signalling: neu tack on neuregulin. Nature 378: 334.
44. Marchionni, M.A., A.D. Goodearl, M.S. Chen, O. Bermingham-McDonogh, C. Kirk, M. Hendricks, F. Danehy, D. Misumi, J. Sudhalter, K. Kobayashi, D. Wroblewski, C. Lynch, M. Baldassare, I. Hiles, J.B. Davis, J. Hsuan, J.J. Totty, M. Otsu, R.N. McBurney, M.D. Waterfield, P. Stroobant, and D. Gwynne. 1993. Glial growth factors are alternatively spliced erbB2 ligands expressed in the nervous system. Nature 362: 312.
45. Meyer, D. and C. Birchmeier. 1994. Distinct isoforms of neuregulin are expressed in mesenchymal and neuronal cells during mouse development. Proc. Natl. Acad. Sci. 91: 1064.
46. _. 1995. Multiple essential functions of neuregulin in development. Nature 378: 386.
47. Mokhtarian, F., D.F. McFarlin, and C.S. Raine. 1984. Adoptive transfer of myelin basic protein-sensitized T cells produces chronic relapsing demyelinating disease in mice. Nature 309: 356.
48. erB2. Proc. Natl. Acad. Sci. 92: 1431.
49. Murphy, P., P. Topilko, S. Schneider-Maunoury, T. Seitanidou, A. Baron-Van Evercooren, and P. Charnay. 1996. The regulation of Krox-20 expression reveals important steps in the control of peripheral glial cell development. Development (in press).
50. O'Brien, J.P., S.E. McKinnon, A.R. MacLean, A.R. Hudson, A.L. Dellon, and D.A. Hunter. 1984. A model of chronic nerve compression in the rat. Ann. Plastic Surg. 19: 430.
51. Peles, E. and Y. Yarden. 1993. Neu and its ligands: From an oncogene to neural factors. BioEssays 15: 815.
52. Peles, E., S.S. Bacus, R.A. Koski, H.S. Lu, D. Wen, S.G. Ogden, R.B. Levy, and Y. Yarden. 1992. Isolation of the neu/HER-2 stimulatory ligand: A 44 kd glycoprotein that induces differentiation of mammary tumor cells. Cells 69: 205.
53. Pinkas-Kramarski, R., R. Eilam, O. Spiegler, S. Lavi, N. Liu, D. Chang, D. Wen, M. Schwartz, and Y. Yarden. 1994. Brain neurons and glial cells express Neu differentiation factor/heregulin: A survival factor for astrocytes. Proc. Natl. Acad. Sci. 91: 9387.
54. Plowman, G.D., J.M. Culouscou, G.S. Whitney, J.M. Green, G.W. Carlton, L. Foy, M.G. Neubauer, and M. Shoyab. 1993. Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family. Proc. Natl. Acad. Sci. 90: 1746.
55. Raff, M.C., E. Abney, J.P. Brockes, and A. Hornby-Smith. 1978. Schwann cell growth factors. Cell 15: 813.
56. Rutkowski, J.L., C.J. Kirk, M.A. Lerner, and G.I. Tennekoon. 1995. Purification and expansion of human Schwann cells in vitro. Nat. Med. 1: 80.
57. r tumour antigen. Nature 312: 513.
58. Shah, N.M., M.A. Marchionni, I. Isaacs, P. Stroobant, and D.J. Anderson. 1994. Glial growth factor restricts mammalian neural crest stem cells to a glial fate. Cell 77: 349.
59. Topilko, P., S. Schneider-Maunoury, G. Levi, A. Baron-Van Evercooren, A.B.Y. Chennoufi, T. Seitanidou, C. Babinet, and P. Charnay. 1994. Krox-20 controls myelination in the peripheral nervous system. Nature 371: 796.
60. Trachtenberg, J.T. and W.J. Thompson. 1996. Schwann cell apoptosis at developing neuromuscular junctions is regulated by glial growth factor. Nature 379: 174.
61. Vartanian, T., G. Corfas, Y. Li, G. Fischbach, and K. Stefansson. 1994. A role for the acetylcholine receptor-inducing protein ARIA in oligodendrocyte development. Proc. Natl. Acad. Sci. 91: 11626.
62. Vaught, J.L., P.C. Contreras, M.A. Glicksman, and N.T. Neff. 1996. Potential utility of rhIGF-1 in neuromuscular and/or degenerative disease. CIBA Found. Symp. 196: 18.
63. Verdi, J.M., A.K. Groves, I. Farinas, K. Jones, M.A. Marchionni, L.F. Reichardt, and D.J. Anderson. 1996. A reciprocal cell-cell interaction mediated by neurotrophin-3 and neuregulins controls the early survival and development of sympathetic neuroblasts. Neuron 16: 515.
64. Wen, D., E. Peles, R. Cupples, S.V. Suggs, S.S. Bacus, Y. Luo, G. Trail, S. Hu, S.M. Silbiger, R.B. Levy, R.A. Koski, H.S. Lu, and Y. Yarden. 1992. Neu differentiation factor: A transmembrane glycoprotein containing an EGF domain and an immunoglobulin homology unit. Cell 69: 559.