Structural requirements for a specificity switch and for maintenance of affinity using mutational analysis of a phage-displayed anti-arsonate antibody of Fab heavy chain first complementarity-determining region

Journal of Immunology

Volumn 160, Issue 12, 1998, Pages 5990-5997

  Wong, Yee Wah ^a   Gill, Davinder S ^b   Parhami Seren, Behnaz ^c   Short, Mary K ^d   Sompuram, Seshi Reddy ^e   Margolies, Michael N ^c  

^a OHIO STATE UNIVERSITY   (United States)

^b IntraImmune Therapies Inc   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^e BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARSONIC ACID DERIVATIVE; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN HEAVY CHAIN; MONOCLONAL ANTIBODY;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANTIBODY SPECIFICITY; ARTICLE; BACTERIOPHAGE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; IMMUNOMODULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; SITE DIRECTED MUTAGENESIS;

ANIMALS; ANTIGENIC VARIATION; ARSENICALS; BACTERIOPHAGES; CELL LINE; DNA MUTATIONAL ANALYSIS; GENE LIBRARY; IMMUNOGLOBULIN FAB FRAGMENTS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN VARIABLE REGION; MICE; MUTAGENESIS, SITE-DIRECTED; PEPTIDE MAPPING;

EID: 0004684552     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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