How important are GST polymorphisms in defining clinical phenotypes: Some answers from studies in high-risk groups

Chemico-Biological Interactions

Volumn 133, Issue 1-3, 2001, Pages 91-94

  Strange, Richard C ^a   Spiteri, Monica ^a   Ramachandran, Sudarshan ^a   Fryer, Anthony A ^a  

^a KEELE UNIVERSITY   (United Kingdom)

Author keywords

Clinical phenotype; Glutathione S transferase; Polymorphism; Susceptibility

Indexed keywords

EID: 0003253255     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (4)

1. A.A. Fryer, A. Bianco, M. Hepple, P.W. Jones, R.C. Strange, M.A. Spiteri, Polymorphism at the glutathione S-transferase, GSTP1 locus: a new marker for bronchial hyperresponsiveness and asthma, Am. J. Respir. Crit. Care Med. (2000), in press.
2. S. Ramachandran, J.T. Lear, H. Ramsay, A.G. Smith, B. Bowers, P.E. Hutchinson, P.W. Jones, A.A. Fryer, R.C. Strange, Presentation with multiple cutaneous basal cell carcinomas: association of glutathione S-transferase and cytochrome P450 genotypes with clinical phenotype, Cancer Epidemiol. Biomark. Prev. 8 (1999) 61-67.
3. A. Clairmont, H. Sies, S. Ramachandran, J.T. Lear, A.G. Smith, B. Bowers, P.W. Jones, A.A. Fryer, R.C. Strange, Association of NAD(P)H: quinone oxidoreductase NQO1 null with numbers of basal cell carcinomas: use of a multivariate model to rank the relative importance of this polymorphism and those at other relevant loci, Carcinogenesis 20 (1999) 1235-1240.
4. S. Ramachandran, P.R. Hoban, F. Ichii-Jones, L. Pleasants, F. Ali-Osman, J.T. Lear, A.G. Smith, B. Bowers, P.W. Jones, A.A. Fryer, R.C. Strange, Glutathione S-transferase GSTP1 and cyclin D1 genotypes: association with numbers of basal cell carcinomas in a patient subgroup at high-risk of multiple tumours, Pharmacogenetics (2000), in press.