Kinetic mechanism of microsomal glutathione tranferase 1

Chemico-Biological Interactions

Volumn 133, Issue 1-3, 2001, Pages 141-143

  Morgenstern, Ralf ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Binding stoichiometry; Kinetic mechanism; Microsomal glutathione transferase

Indexed keywords

EID: 0003207699     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (7)

1. R. Morgenstern, G. Lundqvist, V. Hancock, J.W. DePierre, Studies on the activity and activation of rat liver microsomal glutathione transferase, in particular with a substrate analogue series, J. Biol. Chem. 263 (1988) 6671-6675.
2. E. Mosialou, F. Piemonte, C. Andersson, R. Vos, P.J. Van Bladeren, R. Morgenstern, Microsomal glutathione transferase - lipid-derived substrates and lipid dependence, Arch. Biochem. Biophys. 320 (1995) 210-216.
3. R. Morgenstern, A simple alternate substrate test can help determine the aqueous or bilayer location of binding sites for hydrophobic ligands/substrates on membrane proteins, Chem. Res. Toxicol. 11 (1998) 703-707.
4. C. Andersson, F. Piemonte, E. Mosialou, R. Weinander, T.-H. Sun, G. Lundqvist, A.E.P. Adang, R. Morgenstern, Kinetic studies on rat liver microsomal glutathione transferase, consequences of activation, Biochim. Biophys. Acta 1247 (1995) 277-283.
5. A.M. Caccuri, M. Lobello, M. Nuccetelli, M. Nicotra, P. Rossi, G. Antonini, G. Federici, G. Ricci, Proton release upon glutathione binding to glutathione transferase P1-1 - kinetic analysis of a multistep glutathione binding process, Biochemistry 37 (1998) 3028-3034.
6. T.-H. Sun, R. Morgenstern, Binding of glutathione and an inhibitor to microsomal glutathione transferase, Biochem. J. 326 (1997) 193-196.
7. P.J. Jakobsson, R. Morgenstern, J. Mancini, A. Ford-Hutchinson, B. Persson, Common structural features of MAPEG - a widespread superfamily of membrane associated proteins with highly divergent functions in eicosanoid and glutathione metabolism, Protein Sci. 8 (1999) 689-692.