On the aetiopathogenesis of type 1 diabetes: Key roles for innate immunity and dietary antigens?

Experimental and Clinical Endocrinology and Diabetes

Volumn 107, Issue SUPPL. 2, 1999, Pages

  Kolb, Hubert ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Aetiology of type 1 diabetes; Autoimmunity; Diet; Innate immunity

Indexed keywords

EID: 0002638671     PISSN: 09477349     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0029-1212144     Document Type: Article

References (19)

1. Adorini L: Interleukin-12 administration induces T helper type I cells and accelerates autoimmune diabetes in NOD mice. J Exp Med 181: 817-821, 1995
2. Akerblom HK, Knip M: Putative environmental factors in type 1 diabetes. Diabetes Metab Rev 14: 31-67, 1998
3. Atkinson MA, Bowman MA, Campbell L, Darrow BL, Kaufman DL, Maclaren NK: Cellular immunity to a determinant common to glutamate decarboxylase and Coxsackie virus in insulin-dependent diabetes. J Clin Invest 94: 2125-2129, 1994
4. Bach JF, Otto H, Jung G, Cohen H, Boitard C, Bach JM, van Endert M: Identification of mimicry peptides based on sequential motifs of epitopes derived from 65-kDa glutamic acid decarboxylase. Eur J Immunol 28: 1902-1910, 1998
5. -T-Cell deficiency and IDDM in NOD/Lt mice. Diabetes 46: 572-582, 1997
6. Bellmann K, Kolb H, Rastegar S, Jee P, Scott FW: Potential risk of oral insulin with adjuvant for the diabetes prevention of type 1 diabetes: a protocol effective in NOD mice exacerbates disease in BB rats. Diabetologia 41: 844-847, 1998
7. Charlton B, Bacelj BA, Mandel TE: Administration of silica particals or anti-Lyt2 antibodies prevents b-cell destruction in NOD mice given cyclophosphamide. Diabetes 37: 930-936, 1988
8. Chen W, Syldath U, Bellmann K, Kolb H: Human 60-kD heat shock protein: a danger signal to the innate immune system. J Immunol in press
9. Fearon DT: Seeking wisdom in innate immunity. Nature 388: 323-324, 1997
10. O'Hara R, Henderson SL, Nagelin A: Prevention of a Th1 disease by a Th1 cytokine: IL-12 and diabetes in NOD mice. Ann NY Acad Sci 759: 241-249, 1996
11. Oschilewski U, Kiesel U, Kolb H: Administration of silica prevents diabetes in BB rats. Diabetes 34: 197-202, 1985
12. Rabinovitch A: Immunoregulatory and cytokine imbalances in the pathogenesis of IDDM. Diabetes 43: 613-621, 1994
13. Reizis B, Eisenstein M, Mor F, Cohen IR: The peptide-binding strategy of the MHC class II I-A molecules. Immunol today 19: 212-216, 1998
14. H2 responses: a key role for the 'natural' immune response? Immunol today 13: 379-381, 1992
15. Rothe H, Fehsel K, Kolb H: Tumour necrosis factor alpha production is upregulated in diabetes prone BB rats. Diabetologia 33: 573-575, 1990
16. Voorby HAM, Jeucken PHM, Kabel PJ, DeHaan M, Drexhage HA: Dendritic cells and scavenger macrophages in the pancreatic islets of prediabetic BB rats. Diabetes 38: 1623-1629, 1989
17. Wilson SB, Kent SC, Patton KT, Orban T, Jackson RA, Exley M, Porcelli S, Schatz DA, Atkinson MA, Balk SP, Strominger JL, Hafler DA: Extreme Th1 bias of invariant Va24JaQT cells in type 1 diabetes. Nature 391: 177-181, 1998
18. Yasunami R, Bach JF: Anti-suppressor effect of cyclophosphamide on the development of spontaneous diabetes in NOD mice. Eur J Immunol 18: 481-484, 1988
19. Ziegler A-G, Erhard J, Lampeter EF, Nagelkerken LM, Standl E: Involvement of dendritic cells in early insulitis of BB rats. J Autoimmun 5: 571-579, 1992