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Volumn , Issue 1, 1998, Pages 51-52

A practical synthesis of (1S, 2R)-1-amino-2-indanol, a key component of HIV protease inhibitor, indinavir

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Indexed keywords


EID: 0002570212     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-1998-3126     Document Type: Article
Times cited : (42)

References (50)
  • 18
    • 0013573601 scopus 로고    scopus 로고
    • JP Patent 96-228586
    • Oda, Y.; Yuasa, M. JP Patent 96-228586, Chem. Abstr. 124 : 145646.
    • Chem. Abstr. , vol.124 , pp. 145646
    • Oda, Y.1    Yuasa, M.2
  • 20
    • 26844466833 scopus 로고    scopus 로고
    • note
    • Ee was determined by HPLC (DAICEL CHIRALCEL OB analytical column (0.46 mm, 25 cm)) analysis after conversion to the corresponding methyl ester using trimethylsilyldiazomethane.
  • 25
    • 85088545676 scopus 로고    scopus 로고
    • note
    • D = -19 (c 1.0, MeOH).
  • 29
    • 85088547100 scopus 로고    scopus 로고
    • note
    • 3 (65%) exhibit relatively good yield after 24 h.
  • 30
    • 85088546684 scopus 로고    scopus 로고
    • note
    • 3): See ref 6.
  • 32
    • 85064667331 scopus 로고
    • 3 in aqueous media is seen in (b) Kobayashi, S. Synlett 1994, 689, and references cited therein.
    • (1994) Synlett , pp. 689
    • Kobayashi, S.1
  • 37
    • 26844543218 scopus 로고    scopus 로고
    • note
    • The geometry of 9 was determined by NOE experiments after conversion to 2-acetoxy-1-acetoxyiminoindanone.
  • 38
    • 85088545997 scopus 로고    scopus 로고
    • note
    • Rs observed at a flow rate of 0.5 mL·min-1 were as follows: 14.7 min (R-form), 20.2 min (S-form). Analysis of Z-9 was performed by DAICEL CHIRALPAK AD analytical column (0.46 mm, 25 cm) with 14% 2-propanol in hexane as an eluent.
  • 45
    • 26844554832 scopus 로고    scopus 로고
    • JP Patent 95-242614
    • (g) Oda, Y.; Yuasa, M. JP Patent 95-242614, Chem. Abstr. 124 : 55593.
    • Chem. Abstr. , vol.124 , pp. 55593
    • Oda, Y.1    Yuasa, M.2
  • 46
    • 85088546817 scopus 로고    scopus 로고
    • note
    • 2, 82%, and 28%; Ir black, 89%, and 31%, and Rh black, 75%, and 33%.
  • 47
    • 26844480594 scopus 로고    scopus 로고
    • note
    • Even when the E- or Z-isomer was used respectively as a substrate, the ratio of cis and trans did not change, as might be expected on the basis of the isomerization experiment in an acidic solution.
  • 48
    • 85088547169 scopus 로고    scopus 로고
    • note
    • 4 aq. (pH 2).


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.