Creatine Supplementation

Strength and Conditioning Journal

Volumn 21, Issue 4, 1999, Pages 13-23

  Haff, G Gregory ^a   Kirksey, K Brett ^b   Stone, Michael H ^b  

^a UNIVERSITY OF KANSAS   (United States)

^b APPALACHIAN STATE UNIVERSITY   (United States)

Author keywords

Dietary supplements; Ergonomic aids; Phosphocreatine

Indexed keywords

EID: 0002500402     PISSN: 15241602     EISSN: None     Source Type: Journal    
DOI: 10.1519/00126548-199908000-00003     Document Type: Article

References (73)

1. Alamada, A., T. Mithcell, and C. Earnest. Impact of chronic supplementation on serum enzyme concentrations. FASEB J. 10:A791. 1996.
2. Andrews, R., P. Greenhaff, S. Curtis, A. Perry, and A.J. Cowley. The effect of dietary creatine supplementation on skeletal muscle metabolism in congestive heart failure [see comments]. Eur. Heart J. 19:617-622. 1998.
3. Armsey, T.D., and G.A. Green. Nutritional supplements: Science vs hype. Physician Sports Med. 25:76-78,87-96. 1997.
4. Balsora, P.D., B. Ekblom, K. Soderlund, B. Sjodin, and E. Hultman. Creatine supplementation and dynamic high-intensity intermittent exercise. Scand. J. Med. Sci. Sports 3:142-149. 1993.
5. Baisora, P.D., S.D. Harridge, K. Soderlund, B. Sjodin, and B. Ekblom. Creatine supplementation per se does not enhance endurance exercise performance. Acta Physiol. Scand. 149:521-523. 1993.
6. Balsom, P.D., K. Soderlund, and B. Ekblom. Creatine in humans with special reference to creatine supplementation. Sports Med. 18:268-280. 1994.
7. Becque, B., J. Lochmann, and D. Melrose. Effect of creatine supplementation during strength training on 1 RM and body composition. Med. Sci. Sports Exerc. 29:S146. 1997.
8. Bessman, S.P. A contribution to the mechanism of diabetes mellitus. In: Fat Metabolism, V. Najjar, ed. Baltimore: Johns Hopkins Press, 1954. pp. 133-137.
9. Bessman, S.P., and C.L. Carpenter. The creatine-creatine phosphate energy shuttle. Annu. Rev. Biochem. 54:831-862. 1985.
10. Bessman, S.P., and F. Savabi. The role of the phosphocreatine energy shuttle in exercise and muscle hypertrophy. In: Biochemistry of Exercise VII. A.W. Taylor, P.D. Gollnick, H.J. Green, C.D. Ianuzzo, E.G. Noble, G. Metivier, and J.R. Sutton, eds. Champaign, IL: Human Kinetics, 1990. pp. 167-178.
11. Bramberger, M. The magic potion. Sports Illustrated 88: 58-65. 1998.
12. Burke, L.M., D.B. Pyne, and R.D. Telford. Effect of oral creatine supplementation on single-effort sprint performance in elite swimmers. Int. J. Sports Nutr. 6:222-233. 1996.
13. Clark, J.F. Creatine and phosphocreatine: A review of their use in exercise and sport. J. Athl. Train. 32:45-51. 1997.
14. Cooke, W.H., P.W. Grandjean, and W.S. Barnes. Effect of oral creatine supplementation on power output and fatigue during bicycle ergometry. J. Appl. Physiol. 78:670-673. 1995.
15. Delanghe, J., J.P. De Slypere, M. De Buyzere, J. Robbrecht, R. Wieme, and A. Vermeulen. Normal reference values for creatine, creatinine, and carnitine are lower in vegetarians [letter]. Clin. Chem. 35: 1802-1803. 1989.
16. Earnest, C., A. Almada, and T. Mitchell. Influence of chronic creatine supplementation on hepatorenal function. FASEB J. 10:A790. 1996.
17. Earnest, C.P., A.L. Almada, and T.L. Mitchell. High-performance capillary electrophoresis-pure creatine monohydrate reduces blood lipids in men and women. Clin. Sci. (Colch) 91:113-118. 1996.
18. Earnest, C.P., P.G. Snell, R. Rodriguez, A.L. Almada, and T.L. Mitchell. The effect of creatine monohydrate ingestion on anaerobic power indices, muscular strength and body composition. Acta Physiol. Scand. 153:207-209. 1995.
19. Fagbemi, O., K.A. Kane, and J.R. Parratt. Creatine phosphate suppresses ventricular arrhythmias resulting from coronary artery ligation. J. Cardiovasc. Pharmacol. 4:53-58. 1982.
20. Fitch, C.D. Significance of abnormalities of creatine metabolism. In: Pathogenesis of Human Muscular Dystrophies. L.P. Rowland, ed. Amsterdam, The Netherlands: Exerpta Medica, 1977. pp. 328-340.
21. Fitch, C.D., and R.P. Shields. Creatine metabolism in skeletal muscle. I. Creatine movement across muscle membranes. J. Biol. Chem. 241: 3611-3614. 1966.
22. Flisinska-Bojanowska, A. Effect of oral creatine administration on skeletal muscle protein and creatine levels. Biol. Sport 13:39-46. 1996.
23. Godly, A., and J. Yates. Effects of creatine supplementation on endurance cycling combined with short duration, high intensity bouts. Med. Sci. Sports Exerc. 29: S146. 1997.
24. Gordon, A., E. Hultman, L. Kaijser, S. Kristjansson, C.J. Roll, O. Nyquist, and C. Sylven. Creatine supplementation in chronic heart failure increases skeletal muscle creatine phosphate and muscle performance. Cardiovasc. Res. 30:413-418. 1995.
25. Green, A.L., E. Hultman, I.A. Macdonald, D.A. Sewell, and P.L. Greenhaff. Carbohydrate ingestion augments skeletal muscle creatine accumulation during creatine supplementation in humans. Am. J. Physiol. 271:E821-E826. 1996.
26. Green, A.L., E.J. Simpson, J.J. Littlewood, I.A. Macdonald, and P.L. Greenhaff. Carbohydrate ingestion augments creatine retention during creatine feeding in humans. Acta Physiol. Scand. 158:195-202. 1996.
27. Greenhaff, P.L., K. Bodin, A. Casey, D. Constantin-Teodosiu, A. Green, K. Soderlund, J. Timmons, and E. Hultman. Dietary creatine supplementation and fatigue during high-intensity exercise in humans. In: Biochemistry of Exercise IX. R.J. Maughan and S.M. Shirreffs, eds. Champaign, IL: Human Kinetics, 1996, pp. 219-242.
28. Greenhaff, P.L., K. Bodin, K. Soderlund, and E. Hultman. Effect of oral creatine supplementation on skeletal muscle phosphocreatine resynthesis. Am. J. Physiol. 266:E725-E730. 1994.
29. Greenhaff, P.L., A. Casey, A.H. Short, R. Harris, K. Soderlund, and E. Hultman. Influence of oral creatine supplementation of muscle torque during repeated bouts of maximal voluntary exercise in man. Clin. Sci. (Colch) 84:565-571. 1993.
30. Harris, R.C., E. Hultman, and L.O. Nordesjo. Glycogen, glycolytic intermediates and high-energy phosphates determined in biopsy samples of musculus quadriceps femoris of man at rest. Methods and variance of values. Scand. J. Clin. Lab. Invest. 33:109-120. 1974.
31. Harris, R.C., K. Soderlund, and E. Hultman. Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation. Clin. Sci. (Colch) 83: 367-374. 1992.
32. Hartsock, A. KU and creatine. Lawrence Journal World. Wednesday, August 26, 1998. p. 1C, 6C.
33. Hawes, K. Creatine boom creates administrative challenges. The NCAA News Online (http://www.ncaa.org/ news/19980914/active/35 32n03.html). 1998.
34. Hearse, D.J., K. Tanaka, R. Crome, and A.S. Manning. Creatine phosphate and protection against reperfusion-induced arrhythmias in the rat heart. Eur. J. Pharmacol. 131:21-30. 1986.
35. Heymsfield, S.B., C. Arteaga, C. McManus, J. Smith, and S. Moffitt. Measurement of muscle mass in humans: Validity of the 24-hour urinary creatinine method. Am. J. Clin. Nutr. 37:478-494. 1983.
36. Hirvonen, J., S. Rehunen, H. Rusko, and M. Harkonen. Breakdown of high-energy phosphate compounds and lactate accumulation during short supramaximal exercise. Eur. J. Appl. Physiol. 56:253-259. 1987.
37. Hultman, E., P.L. Greenhaff, J.M. Ren, and K. Soderlund. Energy metabolism and fatigue during intense muscle contraction. Biochem. Soc. Trans. 19:347-353. 1991.
38. Hultman, E., K. Soderlund, J.A. Timmons, G. Cederblad, and P.L. Greenhaff. Muscle creatine loading in men. J. Appl. Physiol. 81:232-237. 1996.
39. Ingwall, J.S. Creatine and the control of muscle-specific protein synthesis in cardiac and skeletal muscle. Circ. Res. 38:1115-1123. 1976.
40. Ingwall, J.S., M.F. Morales, and F.E. Stockdale. Creatine and the control of myosin synthesis in differentiating skeletal muscle. Proc. Natl. Acad. Sci. USA 69:2250-2253. 1972.
41. Ingwall, J.S., M.F. Morales, F.E. Stockdale, and K. Wildenthal. Creatine: A possible stimulus skeletal cardiac muscle hypertrophy. Recent Adv. Stud. Cardiac Struct. Metab. 8:467-481. 1975.
42. Ingwall, J.S., C.D. Weiner, M.F. Morales, E. Davis, and F.E. Stockdale. Specificity of creatine in the control of muscle protein synthesis. J. Cell Biol. 62:145-151. 1974.
43. Ingwall, J.S., and K. Wildenthal. Role of creatine in the regulation of cardiac protein synthesis. J. Cell Biol. 68: 159-163. 1976.
44. Kirksey, B., M.H. Stone, B.J. Warren, R.L. Johnson, M. Stone, G.G. Haff, F.E. Williams, and C. Proulx. The effects of six weeks of creatine monohydrate supplementation on performance measures and body composition in collegiate track and field athletes. J. Strength Cond. Res. In press.
45. Kreider, R.B. Creatine supplement: Analysis of ergogenic value, medical safety, and concerns. Journal of Exercise Physiology Online 1. (http://www.css.edu/users/ tboone2/asep/jan3.htm). 1998.
46. Kreider, R.B., M. Ferreira, M. Wilson, P. Grindstaff, S. Plisk, J. Reinardy, E. Cantler, and A.L. Almada. Effects of creatine supplementation on body composition, strength, and sprint performance. Med. Sci. Sports Exerc. 30:73-82. 1998.
47. Kreider, K., P. Grindstaff, L. Wood, D. Bullen, R. Klesges, and D. Lotz. Effects of ingesting a lean mass promoting supplement during resistance training on isokinetic performance. Med. Sci. Sports Exerc. 28:S36. 1996.
48. Kreider, R.B., C. Rasmussen, J. Ransom, and A.L. Almada. Effects of creatine supplementation during training on the incidence of muscle cramping, injuries, and GI distress. Presentation, National Strength and Conditioning Association Convention. Nashville, TN, 1998.
49. Meyer, R.A., T.R. Brown, B.L. Krilowicz, and M.J. Kushmerick. Phosphagen and intracellular pH changes during contraction of creatine-depleted rat muscle. Am. J. Physiol. 250:C264-C274. 1986.
50. Meyer, R.A., H.L. Sweeney, and M.J. Kushmerick. A simple analysis of the "phosphocreatine shuttle." Am. J. Physiol. 246:C365-C377. 1984.
51. Mujika, I., and S. Padilla. Creatine supplementation as an ergogenic acid for sports performance in highly trained athletes: A critical review. Int. J. Sports Med. 18:491-496. 1997.
52. Pauletto, P., and E. Strumia. Clinical experience with creatine phosphate therapy. In: Creatine and Creatine Phosphate: Scientific and Clinical Perspectives. M.A. Conway and J.F. Clark, eds. San Diego, CA: Academic Press, 1996, pp. 185-197.
53. Poortmans, J.R., H. Auquier, V. Renaut, A. Durussel, M. Saugy, and G.R. Brisson. Effect of short-term creatine supplementation on renal responses in men. Eur. J. Appl. Physiol. 76:566-567. 1997.
54. Poortmans, J.R., and M. Francaux. Renal dysfunction accompanying oral creatine supplements. Lancet 352:234. 1998.
55. Robinson, L.A., M.V. Braimbridge, and D. J. Hearse. Creatine phosphate: An additive myocardial protective and antiarrhythmic agent in cardioplegia. J. Thorac. Cardiovasc. Surg. 87:190-200. 1984.
56. Savabi, F., C.L. Carpenter, C. Mohan, and S.P. Bessman. The polysome as a terminal for the creatine phosphate energy shuttle. Biochem. Med. Metab. Biol. 40:291-298. 1988.
57. Schilling, B., A.C. Fry, J.T. Kearney, L. Smith, H. O'Bryant, A. Utter, R. Keith, and M.H. Stone. Creatine supplementation. Long-term health effects: A retrospective study. The NSCA Pre-Meeting Symposium on Creatine Supplementation. Nashville, TN, 1998.
58. Sipilä, I., J. Rapola, O. Simell, and A. Vannas. Supplementary creatine as a treatment for gyrate atrophy of the choroid and retina. N. Engl. J. Med. 304:867-870. 1981.
59. Stedman, T.L. Medical Dictionary. Baltimore: Williams & Wilkins, 1995.
60. Steenge, G.R., J. Lambourne, A. Casey, I.A. Macdonald, and P.L. Greenhaff. The effect of insulin on muscle creatine accumulation in man. J. Physiol. 506P: 103P. 1998.
61. Tarnopolsky, M.A., B.D. Roy, and J.R. MacDonald. A randomized, controlled trial of creatine monohydrate in patients with mitochondrial cytopathies. Muscle Nerve 20: 1502-1509. 1997.
62. Terrillion, K.A., F.W. Kolkhorst, F.A. Dolgener, and S.J. Joslyn. The effect of creatine supplementation on two 700-m maximal running bouts. Int. J. Sport Nutr. 7:138-143. 1997.
63. Vandebuerie, F., B. Vanden Eynde, K. Vandenberghe, and P. Hespel. Effect of creatine loading on endurance capacity and sprint power in cyclists. Int. J. Sports Med. 19:490-495. 1998.
64. Volek, J. Creatine monohydrate: Is it a performance enhancer? SCAN's Pulse 15: 5-6. 1996.
65. Volek, J.S. Creatine supplementation and its possible role in improving physical performance. ACSM's Health Fitness J. 1:23-29. 1997.
66. Volek, J.S., and W.J. Kraemer. Creatine supplementation: Its effect on human muscular performance and body composition. J. Strength Cond. Res. 10:200-210. 1996.
67. Volek, J.S., W.J. Kraemer, J.A. Bush, M. Boetes, T. Incledon, K.L. Clark, and J.M. Lynch. Creatine supplementation enhances muscular performance during high intensity resistance exercise. J. Am. Diet. Assoc. 97:765-770. 1997.
68. Walker, I.B. Metabolic control of creatine biosynthesis. II: Restoration of transamidinase activity following creatine repression. J. Biol. Chem. 236:493-498. 1960.
69. Walker, I.B. Creatine: Biosynthesis, regulation and function. Adv. Enzymol. Relat. Areas Mol. Med. 50:177-242. 1979.
70. Williams, M.H., and J.D. Branch. Creatine supplementation and exercise performance: An update. J. Am. Coll. Nutr. 17:216-234. 1998.
71. Ziegenfuss, T.N., D. Bredle, M. Rogers, B. Newcomer, M. Boska, and P. Lemon. Effect of creatine on repeated maximal muscle contractions. Can. J. Appl. Physiol. 19:53. 1994.
72. Ziegenfuss, T., P.V. Lemon, M.R. Rogers, R. Ross, and K.E. Yarasheski. Acute creatine ingestion: Effects on muscle volume, anaerobic power, fluid volumes, and protein turnover. Med. Sci. Sports Exerc. 29:S127. 1997.
73. Ziegenfuss, T.N., L.M. Lowery, and P. Lemon. Acute volume changes in men during three days of creatine supplementation. Journal of Exercise Physiology Online. (http://www. css.edu/users/tboone2/asep /janl3d.htm). pp. 1-10. 1998.