Angiotensin receptor blocker selectivity at the AT1- and AT2-receptors: Conceptual and clinical effects

JRAAS - Journal of the Renin-Angiotensin-Aldosterone System

Volumn 1, Issue SUPPL. 2, 2000, Pages 6-9

  Unger, Thomas ^a   Sandmann, Steffen ^a  

^a UNIVERSITY OF KIEL   (Germany)

Author keywords

Ang II receptor blocker; Angiotensin II AT2 receptor; Intracellular pH regulation; Myocardial infarction; Na+ H+ exchange; Valsartan

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; ANGIOTENSIN 2 RECEPTOR;

ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; DRUG EFFECT; GENETICS; HUMAN; HYPERTENSION; PATHOLOGY; PH; PHYSIOLOGY;

ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; CELL DIFFERENTIATION; CELL PROLIFERATION; HUMANS; HYDROGEN-ION CONCENTRATION; HYPERTENSION; RECEPTOR, ANGIOTENSIN, TYPE 1; RECEPTOR, ANGIOTENSIN, TYPE 2;

EID: 0002482489     PISSN: 14703203     EISSN: None     Source Type: Journal    
DOI: 10.3317/jraas.2000.057     Document Type: Article

References (11)

1. Cody RJ. The clinical potential of renin inhibitors and angiotensin antagonists. Drugs 1994;47:586-98.
2. 2-receptor: variations on an enigmatic theme. J Hypertension 1999;17:1775-86.
3. 2-receptor mediates inhibition of cell proliferation in coronary endothelial cells. J Clin Invest 1995;95(2):651-7.
4. 1-receptor: gain-of-function study using gene transfer. Proc Natl Acad Sci USA 1995;92(23):10663-7.
5. Pfeffer MA, Pfeffer JM, Fishbein MC et al. Myocardial infarct size and ventricular function in rats. Circ Res 1979;44: 503-12.
6. Lazdunski M, Frelin C, Vigne P. The sodium/hydrogen exchange system in cardiac cells: its biochemical and pharmacological properties and its role in regulating internal concentrations of sodium and internal pH. J Mol Cell Cardiol 1985; 17(11):1029-42.
7. Thomas RC. Cell growth factors. Bicarbonate and pHi response. Nature 1989;337(6208): 601.
8. Grace AA, Metcalfe JC, Weissberg PL et al. Angiotensin II stimulates sodium-dependent proton extrusion in perfused ferret heart. Am J Physiol 1996;270:C1687-94.
9. Kohout TA, Rogers TB. Angiotensin II activates the Na+/HCO3-symport through a phosphoinositide-independent mechanism in cardiac cells. J Biol Chem 1995;270:20432-8.
10. Zhu YZ, Zhu YC, Li J et al. Effects of losartan on haemodynamic parameters and angiotensin receptor mRNA levels in rat heart after myocardial infarction. JRAAS 2000; 1(3):257-62.
11. 3-cotransporter in the rat heart after myocardial infarction, (submitted for publication).