Changes in expression of lymphocyte amyloid precursor protein mRNA isoforms in normal aging and Alzheimer's disease

Molecular Brain Research

Volumn 35, Issue 1-2, 1996, Pages 260-268

  Ebstein, Richard P ^a   Nemanov, Lubov ^a   Lubarski, Gregory ^a   Dano, Marina ^b   Trevis, Teres ^b   Korczyn, Amos D ^b  

^a HERZOG HOSPITAL   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

Author keywords

Aging; Alternative splicing; Alzheimer's disease; Amyloid precursor protein; Amyloid precursor protein mRNA; Reverse transcriptase PCR

Indexed keywords

AMYLOID PRECURSOR PROTEIN; MESSENGER RNA;

ADULT; AGED; AGING; ALZHEIMER DISEASE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; LYMPHOCYTE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ANALYSIS;

EID: 0030070884     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0169-328X(95)00227-J     Document Type: Article

References (56)

1. Abe, K., Tanzi, R.E. and Kogure, K., Selective induction of Kunitz-type protease inhibitor domain-containing amyloid precursor protein mRNA after persistent focal ischemia in rat cerebral cortex, Neurosci. Lett., 125 (1991) 172-174.
2. Allen, J.S., Murphy, G.M., Eng, L.F., Stulz, K.E., Davies, H.D., Pickford, L.B. and Tinklenberg, J.R., Alzheimer's disease: beta-amyloid precursor protein mRNA expression in mononuclear blood cells, Neurosci. Lett., 132 (1991) 109-112.
3. Anderson, J.P., Esch, F.S., Keim, P.S., Sambamurti, K., Lieberburg, I. and Robakis, N.K., Exact cleavage site of Alzheimer amyloid precursor in neuronal PC-12 cells, Neurosci. Lett., 128 (1991) 126-8.
4. Burdick, D., Soreghan, B., Kwon, M. and et al., Assembly and aggregation properties of synthetic Alzheimer's A4/beta amyloid peptide analogs, J. Biol. Chem., 267 (1992) 546-54.
5. Bush, A.I., Beyreuther, K. and Masters, C.L., The beta-A4 amyloid protein precursor in human circulation. In R.M. Nitsch, J.H. Growdon, S. Corkin and R. Wurtman (Eds.), Alzheimer's Disease: Amyloid Precursor Proteins, Signal Transduction, and Neuronal Transplantation, New York Acad. Sci., New York, 1993, pp. 175-182.
6. Bush, A.I., Martins, R.N., Rumble, B., Moir, R., Fuller, S., Milward, E., Currie, J., Ames, D., Weidemann, A., Fischer, P., Multhaup, G., Beyreuther, K. and Masters, C.L., The amyloid precursor protein of Alzheimer's disease is released by human platelets, J. Biol. Chem., 265 (1990) 15977-15983.
7. Castano, E.M., Ghiso, J., Prelli, F., Gorevic, P.D., Migheli, A. and Frangione, B., In vitro formation of amyloid fibrils from two synthetic peptides of different lengths homolgous to Alzheimer's disease beta-protein, Biochem. Biophys. Res. Commun., 141 (1986) 782-789.
8. Citron, M., Vigo-Pelfrey, C., Teplow, D.B., Miller, C., Schenk, D., Johnston, J., Winblad, B., Venizelos, N., Lannfelt, L. and Selkoe, D., Excessive production of β-amyloid protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation, Proc. Natl. Acad. Sci. USA, 91 (1994) 11993-11997.
9. Coffman, A.D. and Cohen, S., Aging and defective lymphoid cell activation, Exp. Gerontol., 24 (1989) 437.
10. Eikelenboom, P., Zhan, S.S., van Gool, W.A. and Allsop, D., Inflammatory mechanisms in Alzheimer's disease, TIPS, 15 (1994) 447-450.
11. Goedert, M., Neuronal localization of amyloid beta protein precursor mRNA in normal brain and Alzheimer's disease, EMBO J., 6 (1987) 3627-3632.
12. Golde, T.E., Estus, S., Usiak, M., Younkin, L.H. and Younkin, S.G., Expression of beta amyloid protein precursor mRNAs: Recognition of a novel alteratively spliced form and quantitation in Alzheimer's disease using PCR, Neuron, 4 (1990) 253-267.
13. Higgins, G.A., Lewis, D.A., Bahmanyar, S., Goldgaber, D., Gadjusek, D.C., Young, W.G., Morrison, J.H. and Wilson, M.C., Differential regulation of amyloid-beta-protein mRNA expression within hippocampal neronal subpopulations in Alzheimer disease, Proc. Natl. Acad. Sci. USA, 85 (1988) 1297-1301.
14. Horikoshi, T., Danenberg, K.D., Stadibauer, T.H.W., Volkenandt, M., Shea, L.C.C, Aigner, K., Gustavsson, B., Leichman, L., Frosing, R., Ray, M., Gibson, N.W., Spears, C.P. and Danenberg, P.V., Quantitation of thymidylate synthetase, dihydrofolate reductase and DT-diaphorase gene expression in human tumors using the polymerase chain reaction, Cancer Res., 52 (1992) 108-116.
15. Itagaki, S., McGeer, P.L. and Akiyama, H., Presence of T-cytotoxic suppressor and leukocyte common antigen positive cells in Alzheimer's disease brain tissue, Neurosci. Lett., 91 (1988) 259-264.
16. Itagaki, S., McGeer, P.L., Akiyama, H., Zhu, S. and Selkoe, D.J., Relationship of microglia and astrocytes to amyloid deposits of Alzheimer's disease, J. Neuroimmunol., 24 (1989) 173-182.
17. Jacobsen, J.S., Muenkel, H.A., Blume, A.J. and Vitek, M.P., A novel species-specific RNA related to alternatively spliced amyloid precursor mRNAs, Neurobiol. Aging, 12 (1991) 575-583.
18. Joachim, C.L., Mori, H. and Selkoe, D.J., Amyloid beta-protein deposition in tissues other than brain in Alzheimer's disease, Nature, 341 (1989) 226-230.
19. Johnson, S.A., Mcneill, T., Cordell, B. and Finch, C.E., Relation of neuronal APP-751/APP-695 mRNA ratio and neuritic plaque density in Alzheimer's disease, Science, 248 (1990) 854-857.
20. Johnston, J.A., Cowburn, R.F., Norgren, S., Wiehager, B., Venizelos, N., Winblad, B., Vigo-Pelfrey, C., Schenk, D., Lannfelt, L. and O'Neill, C., Increased beta-amyloid release and levels of amyloid precursor protein (APP) in fibroblast cell lines from family members with the Swedish Alzheimer's disease APP670/671 mutation, FEBS Lett., 354 (1994) 274-278.
21. Kidd, M., Alzheimer's disease-an electron microscopal study, Brain, 87 (1964) 307-320.
22. Kirschner, D.A., Inouye, H., Duffy, L.K., Sinclair, A. and Selkoe, D.J., Synthetic beta-peptide of Alzheimer's disease forms amyloid-like fibrils in vitro, Proc. Natl. Acad. Sci. USA, 84 (1987) 6953-6957.
23. Kitaguchi, N., Takahashi, Y., Tokushima, Y., Satoshi, S. and Hirataka, I., Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity, Nature, 331 (1988) 530-532.
24. Konig, G., Monning, U., Czech, C., Prior, R., Banati, R., Schreiter-Gasser, U., Bauer, J., Masters, C.L. and Beyreuther, K., Identification and differential expression of another alternative splice isoform of the beta-A4 amyloid precursor protein (APP) mRNA in leukocytes and brain microglial cells, J. Biol. Chem., 267 (1992) 10804-10809.
25. Konig, G., Salbaum, J.M., Wiestler, O., Lang, W., Schmitt, H.P., Masters, C.L. and Beyreuther, K., Alternative splicing of the betaA4 amyloid gene of Alzheimer's disease in cortex of control and Alzheimer's disease patients, Mol. Brain Res., 9 (1991) 259-262.
26. Koo, E.H., Sisodia, S.S., Archer, D.A., Martin, L.J., Weidemann, A., Beyreuther, K., Masters, C.L., Fishcer, P. and Price, D.L., Precursor of amyloid protein in Alzheimer's disease undergoes fast anterograde axonal transport, Proc. Natl. Acad. Sci. USA, 87 (1990) 1561-1565.
27. Ledoux, S., Rebai, N., Dagenais, A., Shaw, I.T., Nalbantoglu, J., Sekaly, R.P. and Cashman, N.R., Amyloid precursor protein in peripheral mononuclear cells is upregulated with cell activation, J. Immunol., 150 (1993) 5566-5575.
28. 1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer beta-protein into filaments, Nature, 372 (1994) 92-94.
29. Maruyama, K., Terakado, K., Usami, M. and Yoshikawa, K., Formation of amyloid-like fibrils in COS cells overexpressing part of the Alzheimer amyloid protein precursor, Nature, 347 (1990) 566-569.
30. McKenzie, J.E., Gentleman, S.M., Roberts, G.W., Graham, D.I. and Royston, M.C., Increased numbers of betaAPP-immunoreactive neurones in the entorhinal cortex after head injury, NeuroReport, 6 (1994) 161-164.
31. Monning U., Konig G., Banati R.B., Mechler H., Czech C., Gehrmann J., Schreiter-Gasser U., Masters C.L. and Beyreuther, K., βA4-amyloid protein precursor in immunocompetent cells, J. Biol. Chem., 267 (1992) 23950-23956.
32. Nakamura, T., Shoji, M., Harigaya, Y., Watanabe, M., Hososda, K., Cheung, T.T., Shaffer, L.M., Golde, T.E., Younkin, L.H., Younkin, S.G. and Hirai, S., Amyloid beta protein levels in cerebrospinal fluid are elevated in early-onset Alzheimer's Disease, Ann. Neurol., 36 (1994) 903-911.
33. Neve, R.L., Finch, E.A. and Dawes, R.L., Expression at the Alzheimer amyloid protein gene transcripts in the human brain, Neuron, 7 (1988) 669-677.
34. Ohyagi, Y., Takahashi, K., Kamegai, M. and Tabira, T.E., Developmental and differential expression of beta amyloid protein precursor mRNAs in mouse brain, Biochem. Biophys. Res. Commun., 67 (54-60) 1990.
35. Palmert, M.R., Golde, T.E., Cohen, M.L., Kovacs, D.M., Tanzi, R.E., Gusella, J.F., Usiak, M.F., Younkin, L.H. and Younkin, S.G., Amyloid protein precursor messenger RNAs: differential expression in Alzheimer's disease, Science, 241 (1988) 1080-1084.
36. Ponte, P., Gonzalez-DeWhitt, P., Schilling, J., Miller, J., Hsu, D., Greenberg, B., Davis, K., Wallace, W., Lieberburg, I., Fuller, F. and Cordell, B., A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors, Nature, 331 (1988) 525-527.
37. Querfurth, H.W., Wijsman, E.M., St George-Hyslop, P.H. and Selkoe, D.J., Beta APP mRNA transcription is increased in cultured fibroblasts from the familial Alzheimer's disease-1 family, Mol. Brain Res., 28 (1995) 319-337.
38. Rabinowe, S.L., Rubin, I.L., George, K.L., Adri, M.N. and Eisenbarth, G.S., Trisomy 21 (Down's syndrome): autoimmunity, aging and monoclonal antibody-defined T-cell abnormalities, J. Autoimmun., 2 (1989) 25.
39. Sandbrink, R., Masters, C.L. and Beyreuther, K., βA4-amyloid protein precursor mRNA isoforms without exon 15 are ubiquitously expressed in rat tissues including brain, but not in neurons, J. Biol. Chem., 269 (1994) 1510-1517.
40. Selkoe, D.J., Physiological production of the beta-amyloid protein and the mechanism of Alzheimer's disease, Trends Neurosci., 16 (1993) 403-409.
41. Siman, R., Card, J.P., Nelson, R.B. and Davis, L.G., Expression of beta-amyloid precursor protein in reactive astrocytes following neuronal damage, Neuron, 3 (1989) 275-285.
42. Singh, V.K., Fudenberg, H.H. and Brown III, F.R., Immunologic dysfunction: simultaneous study of Alzheimer's and older Down's syndrome patients, Mech. Ageing Dev., 37 (1987) 257.
43. --cell mediated suppressor activity, Neurology, 3 (1985) 1635.
44. Smith, C.J., Johnson, E.M., Osborne, P., Freeman, R.S., Neveu, I. and Brachet, P., NGF deprivation and neuronal degeneration trigger altered beta-amyloid precursor protein gene expression in the rat superior cervical ganglia in vivo and in vitro, Mol. Brain Res., 17 (1993) 328-334.
45. St George-Hyslop, P.H., Tanzi, R.E., Polinksy, R.J., Haines, J.L. and et al., The genetic defect causing familial Alzheimer's disease maps on chromosome 21, Science, 235 (1987) 885-890.
46. Tanaka, S., Liu, L., Kimura, J., Shiojiri, S., Takahashi, Y., Kitaguchi, N., Nakamura, S. and Ueda, K., Age-related changes in the proportion of amyloid precursor protein mRNAs in Alzheimer's disease and other neurological disorders, Mol. Brain Res., 15 (1992) 303-310.
47. Tanaka, S., Shiojiri, S., Takahashi, Y., Kitaguchi, N., Ito, H., Kameyama, M., Kiumura, J., Nakamura, S. and Ueda, K., Tissue-specific expression of the three types of beta-protein precursor mRNA: enhancement of protease inhibitor-harboring types in Alzheimer's disease brain, Biochem. Biophys. Res. Commun., 165 (1989) 1406-1414.
48. Tanzi, R.E., Gusella, J.F., Watkins, P.C., Bruns, G.A.P., StGeorge-Hysolop, P., VanKeuren, M.L., Patterson, D., Pagan, S., Kurnit, D.M. and Neve, R.L., Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus, Science, 235 (1987) 880-884.
49. Tanzi, R.E., McClatchey, A.I., Lamperti, E.D., Villa-Komaroff, L., Gusella, J.F. and Neve, R.L., Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease, Nature, 331 (1988) 528-530.
50. Terry, D., The fine structure of neurofibrillary tangles in Alzheimer's disease, J. Neuropathol. Exp. Neurol., 22 (1963) 629-641.
51. Topper, R., Gehrmann, J., Banati, R., Schwarz, M., Block, F., Noth, J. and Kreutzberg, G.W., Rapid appearance of beta-amyloid precursor protein immunoreactivity in glial cells following excitotoxic brain injury, Acta Neuropathol., 89 (1995) 23-28.
52. Ueda, K., Cole, G.M., Sundsmo, M.P., Katzman, R. and Saitoh, T., Decreased adhesiveness of Alzheimer's disease fibroblasts: is amyloid beta-protein precursor involved?, Ann. Neurol., 25 (1989) 246-251.
53. Whitson, J.S., Selkoe, D.J. and Cotman, C.W., Amyloid beta protein enhances the survival of hippocampal neurons in vitro, Science, 243 (1989) 1488-1490.
54. Yamada, T., Araki, E., Izumi, R., Goto, I., Sasaki, H. and Sakaki, Y., Expression of Alzheimer amyloid beta-protein precursor gene in neuronal cells, Gerontology, 37 (Suppl. 1) (1991) 24-30.
55. Yanker, B.A., Dawes, L.R., Fisher, S., Villa-Komaroff, L., Oster-Granite, M.L. and Neve, R.L., Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease, Science, 245 (1989) 417-420.
56. Yoshikawa, K., Aizawa, T. and Hayashi, Y., Degeneration in vitro of post-mitotic neurons overexpressing the Alzheimer amyloid protein precursor, Nature, 359 (1992) 64-67.