Résistance du cytomégalovirus humain aux antiviraux

Virologie

Volumn 1, Issue 2, 1997, Pages 95-102

  Mazeron, M C ^a  

^a HÔPITAL LARIBOISIÈRE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0001926458     PISSN: 12678694     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Crumpacker CS. Ganciclovir. N Engl J Med 1996 ; 335 : 721-9.
2. Erice A, Chou S, Biron KK, Stanat SC, Balfour HH, Jordan MC. Progressive disease due to ganciclovir-resistant cytomegalovirus in immunocompromised patients. N Engl J Med 1989 ; 320 : 289-92.
3. Drew WL, Miner RC, Bush DF, Follansbee SB, Gullett J, Mehalko SG, et al. Prevalence of resistance in patients receiving ganciclovir for serious cytomegalovirus infection. J Infect Dis 1991 ; 163 : 726-9.
4. Tatarowicz W, Lurain NS, Thompson KD. A ganciclovir-resistant isolate of human cytomegalovirus exhibiting cross-resistance to other DNA polymerase inhibitors. J Infect Dis 1992 ; 166 : 904-7.
5. Alain S, Mazeron MC, Pepin JM, Morinet F, Raskine L, Sanson-Le Pors MJ. Rapid detection of cytomegalovirus strains resistant to ganciclovir through, mutations within the gene UL97. Mol Cell Probe 1993 ; 7 : 487-95.
6. Drew WL, Miner RC, Crager M, Stempien MJ. Prevalence of ganciclovir-resistant cytomegalovirus during oral ganciclovir prophylaxis. 3rd Conference on Retroviruses and Opportunistic Infections, 1996.
7. Boivin G, Erice A, Crane DD, Dunn DL, Balfour HH. Ganciclovir susceptibilities of cytomegalovirus (CMV) isolates from solid organ transplant recipients with CMV viremia after antiviral prophylaxis. J Infect Dis 1993 ; 168 : 332-5.
8. Darlington J, Super M, Patel K, Grundy JE, Griffiths PD, Emery VC. Use of the polymerase chain reaction to analyse sequence variation within a major neutralizing epitope of glycoprotein B (gp58) in clinical isolates of human cytomegalovirus. J Gen Virol 1991 ; 62 : 1985-9.
9. Pépin JM, Simon F, Dussault A, Collin G, Dazza MC, Brun-Vézinet F Rapid determination of human cytomegalovirus susceptibility to ganciclovir directly from clinical specimen primocultures. J Clin Microbiol 1992 ; 30 : 2917-20.
10. Gerna G, Sarasini A, Percivalle E, Zavattoni M, Baldanti F, Revello G. Rapid screening for resistance to ganciclovir and foscarnet of primary isolates of human cytomegalovirus from culture-positive blood samples. J Clin Microbiol 1995 ; 33 : 738-41
11. Drew WL, Miner R, Saleh E. Antiviral susceptibility testing of cytomegalovirus : criteria for detecting resistance to antivirals. Clin Diagn Virol 1993 ; 1 : 179-85.
12. Biron KK, Fyfe JA, Stanat SC, Leslie LK, Sorrell JB, Lambe CU, et al. A human cytomegalovirus mutant resistant to the nucleoside analog 9-{[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl}guanine (BW B759U) induces reduced levels of BW B 759U triphosphate. Proc Natl Acad Sci USA 1989 ; 83 : 8769-73.
13. Littler E, Stuart AD, Chee MS. Human cytomegalovirus UL97 open reading frame encodes a protein that phosphorylates the antiviral nucleoside analogue ganciclovir. Nature 1992 ; 358 : 160-2.
14. Sullivan V, Talarico CL, Stanat SC, Davis M, Coen DM, Biron KK. A protein kinase homologue controls phosphorylation of ganciclovir in human cytomegalovirus-infected cells. Nature 1992 ; 358 : 162-4.
15. Stanat SC, Reardon JE, Erice A, Jordan MC, Drew WL, Biron KK. Ganciclovir-resistant cytomegalovirus clinical isolates : mode of resistance to ganciclovir. Antimicrobial Agents Chemother 1991 ; 35 : 2191-7.
16. Hanks SK, Quinn AM, Hunter T. The protein kinase family : conserved features and deduced phylogeny of the catalytic domains. Science 1988 ; 241 : 42-52.
17. Chou S, Erice A, Jordan MC, Vercellotti CM, Michels KR, Talarico CL, Stanat SC, et al. Analysis of the UL97 phosphotransferase coding sequence in clinical cytomegalovirus isolates and identification of mutations conferring gacciclovir resistance. J Infect Dis 1995 ; 171 : 576-83.
18. Wolf DG, Smith IL, Lee DJ, Freeman WR, Flores-Aguilar M, Spector SA. Mutations in human cytomegalovirus UL97 gene confer clinical resistance to ganciclovir and can be detected directly in patient plasma. J Clin Invest 1995 ; 95 : 257-63.
19. Lurain NS, Spafford LE, Thompson KD. Mutation in the UL97 open reading frame of human cytomegalovirus strains resistant to ganciclovir. J Virol 1994 ; 68 : 4427-31.
20. Chou S, Guentzel S, Michels KR, Miner RC, Drew L. Frequency of UL97 phosphotransferase mutations related to ganciclovir resistance in clinical cytomegalovirus isolates. J Infect Dis 1995 ; 172 : 239-42.
21. Hanson MH, Preheim LC, Chou S, Talarico CL, Biron KK, Erice A, Novel mutation in the UL97 gene of a clinical cytomegalovirus strain conferring resistance to ganciclovir. Antimicrobial Agents Chemother 1995 ; 39 : 1204-5.
22. Ye LB, Huang ES. In vitro expression of the human cytomegalovirus DNA polymerase gene : effects of sequence alterations on enzyme activity. J Virol 1993 ; 67 : 6339-47.
23. Sullivan V, Biron KK, Talarico C, Stanat SC, Davis M, Pozzi LM, Coen DM. A point mutation in the human cytomegalovirus DNA polymerase gene confers resistance to ganciclovir and phosphonylmethoxyalkyl derivatives. Antimicrobial Agents Chemother 1993 ; 37 : 19-25.
24. Lurain NS, Thompson KD, Holmes EW, Read GS. Point mutations in the DNA polymerase gene of human cytomegalovirus that result in resistance to antiviral agents. J Virol 1992 ; 66 : 7146-52.
25. Sullivan V, Coen DM. Isolation of foscarnet-resistant human cytomegalovirus patterns of resistance and sensitivity of other antiviral drugs. J Infect Dis 1991 ; 164 : 781-4.
26. Baldanti F, Underwood MK, Stanat SC, Biron KK, Chou S, Sarasini A, Silini E, Gerna G. Single amino acid changes in the DNA polymerase confers foscamet resistance and slow-growth phenotype. while mutations in the UL97-encoded phosphotransferase confer ganciclovir resistance in three double-resistant human cytomegalovirus strains recovered from patients with Aids. J Virol 1996 ; 70 : 1390-5.
27. Gibbs JS, Chiou HC, Bastow F, Cheng YD, Coen DM. Identification of amino acids in herpes simplex virus DNA polymerase involved in substrate and drug recognition. Proc Natl Acad Sci USA 1988 ; 85 : 6672-6.
28. Smith IL, Shinkai M, Freeman WR, Spector SA. Polyradiculopathy associated with ganciclovir-resistant cytomegalovirus in an Aids patient : phenotypic and genotypic characterization of sequential isolates. J Infect Dis 1996 ; 173 : 1481-4.
29. Alain S, Honderlick P, Grenet D, Stern M, Vadam C, Sanson Le Pors, et al. Failure of ganciclovir treatment associated with the selection of an ganciclovir-resistant cytomegalovirus strain in a lung transplant recipient. Transplantation (à paraître).
30. Wolf DG, Lee DJ, Spector SA. Detection of human cytomegalovirus mutations associated with ganciclovir resistance in cerebrospinal fluid of Aids patients with central nervous system disease. Antimicrobial Agents Chemother 1995 ; 39 : 2552-4.
31. Alain S, Mazeron MC, Pépin JM, Bergmann JF, Narwa R, Raskine L, et al. Value of a new rapid non radioactive sequencing method for analysis of the cytomegalovirus UL97gene in ganciclovir-resistant strains. J Virol Methods 1995 ; 51 : 241-51.