Cell cycle specificity of apoptosis during treatment of leukaemias

Apoptosis

Volumn 2, Issue 1, 1997, Pages 25-39

  Halicka, H D ^a   Seiter, K ^b   Feldman, E J ^b   Traganos, F ^a   Mittelman, A ^b   Ahmed, T ^b   Darzynkiewicz, Z ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

^b WESTCHESTER MEDICAL CENTER   (United States)

Author keywords

Cell cycle; DNA damage; DNA strand breaks; Flow cytometry; Necrosis

Indexed keywords

EID: 0001784652     PISSN: 13608185     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1026431524236     Document Type: Article

References (54)

1. Arends MJ, Morris RG, Wyllie AH. Apoptosis: The role of endonuclease. Am J Pathol 1990; 136: 593-608.
2. Wyllie AH. Apoptosis and the regulation of cell numbers in normal and neoplastic tissues: An overview. Cancer Metast Rev 1992; 11: 95-103.
3. Wyllie AH, Arends MJ, Morris RG, Walker SW, Evan G. The apoptosis endonuclease and its regulation. Seminars Immunol 1992; 4: 389-398.
4. Kerr JFR, Winterford CM, Harmon V. Apoptosis. Its significance in cancer and cancer therapy. Cancer 1994; 73: 2013-2026.
5. Kohn KW, Jackman J, O'Connor PM. Cell cycle control and cancer chemotherapy. J Cell Biochem 1994; 54: 440-452.
6. Hockenberry DM. bcl-2 in cancer, development and apoptosis. J Cell Sci 1995, 18: 51-55.
7. Majno G, Joris I. Apoptosis, oncosis, and necrosis. An overview of cell death. Am J Pathol 1995; 146: 3-16.
8. Darzynkiewicz Z. Apoptosis in antitumor strategies: Modulation of cell cycle and differentiation. J Cell Biochem 1995; 58: 151-159.
9. Darzynkiewicz Z, Juan G, Li X, Gorczyca W, Murakami T, Traganos F. Cytometry in cell necrobiology. Analysis of apoptosis and accidental cell death (necrosis). Cytometry 1997; 27: 1-20.
10. Gorczyca W, Bruno S, Darzynkiewicz RJ, Gong J, Darzynkiewicz Z. DNA strand breaks occuring during apoptosis: Their early in situ detection by the terminal deoxynucleotidyl transferase and nick translation assays and prevention by serine protease inhibitors. Int J Oncol 1992; 1: 639-448.
11. Gorczyca W, Bigman K, Mittelman A, et al. Induction of DNA strand breaks associated with apoptosis during treatment of leukemias. Leukemia 1993; 7: 659-670.
12. Li X, Gong J, Feldman E, Seiter K, Traganos F, Darzynkiewicz Z. Apoptotic cell death during treatment of leukemias. Leukemia Lymphoma 1994; 13(Suppl): 65-70.
13. Seiter K, Feldman FJ, Traganos F et al. Evaluation of in vivo induction of apoptosis in patients with acute leukemia treated on a phase I study with Paclitaxel. Leukemia 1995; 9: 1961-1966.
14. BhallaK, Ibrado AM, Bradt JE et al. pIXY321 protects against Ara-C or taxol-induced apoptosis and loss of clonogenic survival of normal human bone marrow progenitor cells. Leukemia 1995; 9: 1851-1856.
15. Raza A, Mundle S, Shetty V et al. Novel insights into biology of myelodysplastic syndromes: excessive apoptosis and role of cytokines. Int J Hematol 1966; 63: 265-276.
16. Seiter K, Feldman EJ, Halicka HD et al. Phase I clinical and laboratory evaluation of topotecan and cytoarabine in patients with acute leukemia. J Clin Oncol 1966 (in press)
17. Fisher DE. Apoptosis in cancer therapy: crossing the threshold. Cell 1994; 78: 539-542.
18. Dive C, Hickmann JA. Drug-target interactions: Only the first step in the commitment to a programmed cell death? Br J Cancer 1991; 64: 192-196.
19. Oltvai ZN, Korsmeyer SJ. Checkpoints of dueling dinners foil death wishes. Cell 1994; 79: 189-192.
20. Galaktionov K, Chen X, Beach D. Cdc25 cell-cycle phosphatase as a target of c-myc. Nature 1996; 382: 511-517.
21. Evan G, Wyllie AH, Gilbert CS, et al. Induction of apoptosis in fibroblasts by c-myc protein. Cell 1992; 69: 119-128.
22. Arends MJ, McGregor AH, Toft NJ, et al. Susceptibility to apoptosis is differentially regulated by c-myc and mutated Ha-ras oncogenes and is associated with endonuclease availability. Br J Cancer 1993; 68: 1127-1133.
23. Harris CC. Structure and function of the p53 tumor suppressor gene: Clues for rational cancer therapeutic strategies. JNCI 1996; 88: 1442-1455.
24. Bhuyan BK, Groppi VE. Cell cycle specific inhibitors. Pharmac Therap 1989; 42: 307-348.
25. Gong J, Traganos F, Darzynkiewicz Z. Growth imbalance and altered expression of cyclins B1, A, E and D3 in MOLT-4 cells synchronized in the cell cycle by inhibitors of DNA replication. Cell Growth Diff 1995; 6: 1485-1493.
26. Gorczyca W, Gong J, Darzynkiewicz Z. Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays. Cancer Res 1993; 52: 1945-1951.
27. Gold R, Schmied M, Giegerich G, et al. Differentiation between cellular apoptosis and necrosis by the combined use of in situ tailing and nick translation techniques. Lab Invest 1994; 71: 219-225.
28. Li X, Darzynkiewicz Z. Labelling DNA strand breaks with BdrUTP. Detection of apoptosis and cell proliferation. Cell Prolif 1995; 28: 571-579.
29. Li X, Melamed MR, Darzynkiewicz Z. Detection of apoptosis and DNA replication by differential labeling of DNA strand breaks with fluorochromes of different color. Exp Cell Res 1996; 222: 28-37.
30. Darzynkiewicz Z, Li X. Measurements of cell death by flow cytometry. In: Cotter TG, Martin SJ, eds. Techniques in Apoptosis: A User's Gidde. London, UK: Portland Press, 1996: 71-106.
31. Gorczyca W, Gong J, Ardelt B, Traganos F, Darzynkiewicz Z. The cell cycle related differences in susceptibility of HL-60 cells to apoptosis induced by various antitumor agents. Cancer Res 1993; 53: 3186-3192.
32. 0 cells and is prevented by inhibitors of proteases. Oncology Res 1992; 4: 29-35.
33. Kerr JFR, Wyllie AH, Curie AR. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 1972; 26: 239-257.
34. Gong J, Traganos F, Darzynkiewicz Z. A selective procedure for DNA extraction from apoptotic cells applicable for gel electrophoresis and flow cytometry. Anal Biochem 1994; 218: 314-319.
35. D'Arpa P, Beardmore C, Liu LF. Involvement of nucleic acid synthesis in cell killing mechanisms of topoisamerase poisons. Cancer Res 1990; 50: 6919-6924.
36. Murakami T, Li, X, Gong J, Bhatia U, Traganos F, Darzynkiewicz Z. Induction of apoptosis by 5-azacytidine: Drug concentration-dependent differences in cell cycle specificity Cancer Res 1995; 55: 3093-3098.
37. Darzynkiewicz Z, Bruno S, Del Bino G, Traganos F. The cell cycle effects of camptothecin. Am NY Acad Sci 1996; (in press)
38. Halicka HD, Ardelt B, Li X, Melamed MR, Darzynkiewicz Z. 2-deoxy-D-glucose enhances sensitivity of human histiocytic lymphoma U937 cells to apoptosis induced by tumor necrosis factor. Cancer Res 1995; 55: 444-449
39. Darzynkiewicz Z, Williamson B, Carswell EA, Old LJ. Cell cycle specific effects of tumor necrosis factor. Cancer Res 1984; 44: 83-90.
40. Hotz MA, Traganos F, Darzynkiewicz Z. Changes in nuclear chromatin related to apoptosis or necrosis induced by the DNA topoisomerase II inhibitor fostriecin in MOLT-4 and HL-60 cells are revealed by altered DNA sensitivity to denaturaticn. Exp Cell Res 1992; 201: 184-191.
41. 1 phase of cell cycle detected by flow cytometry. Proc Natl Acad Sci USA 1980; 77: 6696-6699.
42. Gong J, Li X, Darzynkiewicz Z. Different patterns of apoptosis of HL-60 cells induced by cycloheximide and camptothecin. J Cell Physiol 1993; 157: 263-270.
43. Del Bino G, Skierski J, Darzynkiewicz Z. Diverse effects of camptothecin, an inhibitor of topoisomerase I, on the cell cycle of lymphocytic (L1210, MOLT-4) and myelogenous (HL-60, KG1) leukemic cells. Cancer Res 1990; 50: 5746-5750.
44. Akagi Y, Ito K, Sawada S. Radiation-induced apoptosis and necrosis in Molt-4 cells: a study of dose-effect relationships and their modification. Int J Radiat Biol 1993; 64: 47-56.
45. 2+-dependent endonuclease. Exp Cell Res 1994; 213: 412-417.
46. Aller P, Rius C, Mata F, Zorilla A, Cabanas C, Bellon T, Barnabeu C. Camptothecin induces differentiation and stimulates the expression of differentiation-related genes in U-937 promonocytic leukemia cells. Cancer Res 1992; 52: 1245-1251.
47. Del Bino G, Skierski JS, Darzynkiewicz Z. The concentration-dependent diversity of effects of DNA topoisomerase I and II inhibitors on the cell cycle of HL-60 cells. Exp Cell Res 1991; 195: 485-491.
48. Hotz MA, Gong J, Traganos F, Darzynkiewicz Z. Flow cytometric detection of apoptosis. Comparison of the assays of in situ DNA degradation and chromatin changes. Cytometry 1994 15: 237-244.
49. Del Bino G, Bruno S, Yi PN, Darzynkiewicz Z. Apoptotic cell death triggered by camptothecin or teniposide. The cell cycle specificity and effects of ionizing radiation. Cell Prolif 1992; 25: 537-548.
50. Hotz MA, Del Bino G, Lassota P, Traganos F, Darzynkiewicz Z. Cytostatic and cytotoxic effects of fostriecin on human promyelocytic HL-60 and lymphocytic MOLT-4 leukemic cells. Cancer Res 1992; 52: 1530-1535.
51. Pantazis P, Kozielski AJ, Vardeman DM, Petry ER, Giovanella B. Efficacy of camptothecin cogeners in the treatment of human breast carcinoma xenografts. Oncol Res 1994; 5: 273-281.
52. Slichenmyer WJ, Rowinsky EK, Donehower RC, Kaufmann SH. The current status of camptothecin analogues as antitumor agents. JNCI 1993; 85: 271-291.
53. Traganos F. Seiter K, Feldman E, Halicka HD, Darzynkiewicz Z. Induction of apoptosis by camptothecin and topotecan. Ann NY Acad Sci 1996; 803: 101-110.
54. el-Deiry WS, Tokino T, Velculesco VE et al. WAF1, apotential mediator of p53 tumor suppression. Cell 1993; 75: 813-825.