Nu-Alloc temporary protection in solid-phase peptide synthesis. the use of amine-borane complexes as allyl group scavengers

Journal of the Chemical Society - Perkin Transactions 1

Volumn , Issue 20, 1999, Pages 2871-2874

  Gomez Martinez, Paloma ^a   Dcssolin, Michèle ^b   Guibé, François ^a   Albericio, Fernando ^b  

^a UNIVERSITÉ PARIS SUD   (France)

^b UNIVERSITY OF BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0001561005     PISSN: 0300922X     EISSN: None     Source Type: Journal    
DOI: 10.1039/a906025a     Document Type: Article

References (27)

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22. In the presence of 2 mol% of Pd(PPh3)4, half-reaction times of less than 5 min at room temperature were found, in our laboratory, for the conversion of the Alloc derivatives of morpholine or Nmethylbenzylamine to the corresponding allylamines. As a comparison, the half-conversion times for Alloc-Val-OMe or Alloc-Tyr(O-f-Bu)-OMe under similar conditions are approximatively 1 h.
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24. The concentration of reactants in these control experiments were the same as those used in the deprotection of N"-Alloc derivatives 3 and 4.
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