Ligand Recognition by E- and P-Selectin: Chemoenzymatic Synthesis and Inhibitory Activity of Bivalent Sialyl Lewis x Derivatives and Sialyl Lewis x Carboxylic Acids

Journal of Organic Chemistry

Volumn 63, Issue 15, 1998, Pages 5137-5143

  Wittmann, Valentin ^a   Takayama, Shuichi ^a   Gong, Ke Wei ^a   Weitz Schmidt, Gabriele ^a   Wong, Chi Huey ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0001548741     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo980350s     Document Type: Article

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59. 1H NMR). Their formation is probably due to the presence of excess of base leading to further alkylation of the acidic α-position of the α-oxy-substituted esters present in the products. (A low-yield alkylation of 5 is also reported in: Jaeger, D. A.; Whitney, R. R. J. Org. Chem. 1975, 40, 92-97.) The overalkylation is not observed under the reaction conditions described here (reverse addition and PTC, respectively).
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64. 7
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