A novel one-pot conversion of aldehydes to trifluoromethylated bromoallylic alcohols

Organic Letters

Volumn 3, Issue 18, 2001, Pages 2805-2806

  Shen, Yanchang ^a   Zhang, Yuming ^a  

^a SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

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EID: 0001547791     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol010115n     Document Type: Article

References (32)

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32. 4 (2 mmol) and then 3,3,3-tribromo-1,1,1-trifluoroacetone(2 mmol). After 16 h of stirring at 100°C, the reaction mixture was treated with 5 N HCl solution (40 mL) and dichloromethane (20 mL) and extracted with dichloromethane (2 × 20 mL). The organic layer was washed with water (3 × 10 mL), dried, and evaporated to remove the solvent. The residue was chromatographed on silica gel and eluted with petroleum ether (60-90°C)/ethyl acetate (10:1) to give the product.