Letter: Formation and fragmentation reactions of platinum-terpyridine complexes of glycine and cysteine and their methyl derivatives via electrospray ionization mass spectrometry

European Mass Spectrometry

Volumn 3, Issue 5, 1997, Pages 390-395

  O'Hair, Richard A J ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Cysteine; Electrospray ionization; Glycine; Ion trap mass spectrometer; Platinum terpyridine complexes; Tandem mass spectrometry

Indexed keywords

EID: 0001500994     PISSN: 13561049     EISSN: None     Source Type: Journal    
DOI: 10.1255/ejms.171     Document Type: Article

References (19)

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11. For a review on the electrospray mass spectra of inorganic and organometallic systems see: R. Colton, A. D'Agostino and J.C. Traeger, Mass Spectrom. Rev. 14, 79 (1995).
12. +, where M and M-H represent the neutral and deprotonated amino acid, respectively.
13. C.L. Gatlin, F. Turecek and T. Vaisar, J. Mass Spectrom. 30, 775 (1995).
14. + ion of glycine, where formation of the major product requires translocation (rearrangement) of the proton from the amino group (which is the thermodynamically favoured site of protonation) to the hydroxyl group; see: J.S. Klassen and P. Kebarle, J. Am. Chan. Soc. 119, 6552 (1997).
15. Studies are underway to probe the structures of these ions via ion-molecule reactions and ab initio calculations.
16. M.A. Freitas, R.A.J. O'Hair, J.A.R. Schmidt, S.E. Tichy, B.E. Plashko and T.D. Williams, J. Mass Spectrom. 31, 1086 (1996).
17. We have previously shown that such neighbouring group participation reactions may be involved in the MS/MS of various amino acid derivatives: R.A.J. O'Hair, M.A. Freitas and T.D. Williams, J. Org. Chem. 61, 2374 (1996).
18. + ions are readily formed from histidine and from the cysteine-containing tripeptide glutathione (R.A.J. O'Hair, unpublished observations, June, 1997).
19. Finnigan MAT LCQ™, Finnigan Corporation, San Jose, CA 95134-1991 USA.