The tumor strikes back: New data on expression of the CD95(APO-1/Fas) receptor/ligand system may cause paradigm changes in our view on drug treatment and tumor immunology

Cell Death and Differentiation

Volumn 4, Issue 5, 1997, Pages 362-364

  Krammer, Peter H ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0001455324     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4400252     Document Type: Article

References (12)

1. Debatin K-M (1996) Disturbances of the CD95 (APO-1/Fas) system in disorders of lymphohaematopoietic cells. Cell Death Differ. 3: 185-189
2. Friesen C, Herr I, Krammer PH and Debatin K-M (1996) Involvement of the CD95(APO-1/Fas) receptor/ligand system in drug induced apoptosis in leukemia cells. Nature Medicine 2: 574-577
3. Hahne M, Rimoldi D, Schröter M, Romero P, Schreier M, French LE, Schneider P, Bornand T, Fonatan A, Lienard D, Cerottini J-C and Tschopp J (1996) Melanoma cell expression of Fas(APO-1/CD95) ligand: implications for tumor immune escape. Science 274: 1363
4. Krammer PH (1996) The CD95(APO-1/Fas) receptor/ligand system: death signals and diseases. Cell Death Differ. 3: 159-160
5. Müller M, Strand S, Hug H, Heinemann E-M, Walczak H, Hofmann WJ, Stremmel W, Krammer PH and Galle PR (1977) Drug-induced apoptosis in hepatoma cells involves activation of p53 and is mediated by the CD95/(APO-1/Fas) receptor/ligand system. J. Clin. Invest. 99: 1-11
6. O'Connell J, O'Sullivan GC, Collins JK and Shanahan F (1996) The Fas counterattack: Fas-mediated T cell killing by colon cancer cells expressing Fas ligand. J. Exp. Med. 184: 1075-1082
7. Peter ME, Hellbardt S, Schwartz-Albiez R, Westendorp MG, Walczak H, Moldenhauer G, Brell M and Krammer PH (1995) Cell surface sialylation plays a role in modulating sensitivity towards APO-1-mediated apoptotic cell death. Cell Death Differ. 2: 163-171
8. Peter ME, Kischkel FC, Hellbardt S, Chinnaiyan AM, Krammer PH and Dixit VM (1996) CD95 (APO-1/Fas)-associating signalling proteins. Cell Death Differ. 3: 161-170
9. Schulze-Osthoff K, Bauer MKA, Vogt M and Los M (1996) Role of ICE-realted and other proteases in Fas-mediated apoptosis. Cell Death Differ. 3: 177-184
10. Seino K-I, Kayagaki N, Okumura K and Yagita H (1997) Antitumor effect of locally produced CD95 ligand. Nature Med. 3: 165-170
11. Skowronski EW, Kolesnick RN and Green DR (1996) Fas-mediated apoptosis and sphingomyelinase signal transduction: the role of ceramide as a second messenger for apoptosis. Cell Death Differ. 3: 171-176
12. Strand S, Hofmann WJ, Hug H, Müller M, Otto G, Strand D, Mariani SM, Stremmel W, Krammer PH and Galle PR (1996) Lymphocyte apoptosis induced by CD95 (APO-1/Fas) ligand expressing tumor cells - a mechanism of immune evasion? Nature Med. 12: 1361-66