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Volumn 3, Issue 3, 1998, Pages 246-251

Synthetic biodegradable polymers for tissue engineering and drug delivery

Author keywords

PEG polyethylene glycol

Indexed keywords


EID: 0001275054     PISSN: 13590286     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-0286(98)80098-3     Document Type: Article
Times cited : (101)

References (41)
  • 1
    • 0029007273 scopus 로고
    • Biomaterials in tissue engineering
    • Hubbell J.A. Biomaterials in tissue engineering. Bio/Technology. 13:1995;565-576.
    • (1995) Bio/Technology , vol.13 , pp. 565-576
    • Hubbell, J.A.1
  • 2
    • 0029724374 scopus 로고    scopus 로고
    • Surface treatments of polymers for biocompatibility
    • Elbert D.L., Hubbell J.A. Surface treatments of polymers for biocompatibility. Ann Rev Mater Sci. 26:1996;365-394.
    • (1996) Ann Rev Mater Sci , vol.26 , pp. 365-394
    • Elbert, D.L.1    Hubbell, J.A.2
  • 3
    • 0027595948 scopus 로고
    • Tissue engineering
    • Langer R, Vacanti J.P. Tissue engineering. Science. 260:1993;920-926.
    • (1993) Science , vol.260 , pp. 920-926
    • Langer, R.1    Vacanti, J.P.2
  • 4
    • 0028326051 scopus 로고
    • New challenges in biomaterials
    • Peppas N.A., Langer R. New challenges in biomaterials. Science. 263:1994;1715-1720.
    • (1994) Science , vol.263 , pp. 1715-1720
    • Peppas, N.A.1    Langer, R.2
  • 5
    • 0027544568 scopus 로고
    • Bioerodible hydrogels based on photopolymerized poly(ethylene glycol)-co-poly(α-hydroxy acid) diacrylate macromers
    • Sawhney A.S., Pathak C.P., Hubbell J.A. Bioerodible hydrogels based on photopolymerized poly(ethylene glycol)-co-poly(α-hydroxy acid) diacrylate macromers. Macromolecules. 26:1993;581-587.
    • (1993) Macromolecules , vol.26 , pp. 581-587
    • Sawhney, A.S.1    Pathak, C.P.2    Hubbell, J.A.3
  • 6
    • 0029850466 scopus 로고    scopus 로고
    • Separation of the arterial-wall from blood contact using hydrogel barriers reduces intimal thickening after balloon injury in the rat - The roles of medial and luminal factors in arterial healing
    • West J.L., Hubbell J.A. Separation of the arterial-wall from blood contact using hydrogel barriers reduces intimal thickening after balloon injury in the rat - the roles of medial and luminal factors in arterial healing. Proc Natl Acad Sci USA. 93:1996;13188-13193.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 13188-13193
    • West, J.L.1    Hubbell, J.A.2
  • 7
    • 0030834641 scopus 로고    scopus 로고
    • Characterization of partially saturated poly(propylene fumarate) for orthopedic application
    • A linear unsaturated polyester was formed from fumaric acid and polypropylene glycol. Viscous solutions of this polymer can be formed in a biologically acceptable organic solvent, and it can be crosslinked in situ to fill skeletal or dental defects using minimally invasive methods and instruments.
    • Peter S.J., Yaszemski M.J., Suggs L.J., Payne R.G., Langer R, Hayes WC, Unroe M.R., Alemany L.B., Engel P.S., Mikos A.G. Characterization of partially saturated poly(propylene fumarate) for orthopedic application. J Biomater Sci Polym Ed. 8:1997;893-904 A linear unsaturated polyester was formed from fumaric acid and polypropylene glycol. Viscous solutions of this polymer can be formed in a biologically acceptable organic solvent, and it can be crosslinked in situ to fill skeletal or dental defects using minimally invasive methods and instruments.
    • (1997) J Biomater Sci Polym Ed , vol.8 , pp. 893-904
    • Peter, S.J.1    Yaszemski, M.J.2    Suggs, L.J.3    Payne, R.G.4    Langer, R.5    Hayes, W.C.6    Unroe, M.R.7    Alemany, L.B.8    Engel, P.S.9    Mikos, A.G.10
  • 8
    • 0031557626 scopus 로고    scopus 로고
    • Synthesis and characterization of photo-cross-linked polymers based on poly (L-lactic acid-co-L-aspartic acid)
    • Elisseeff J, Anseth K, Langer R, Hrkach J.S. Synthesis and characterization of photo-cross-linked polymers based on poly (L-lactic acid-co-L-aspartic acid). Macromolecules. 30:1997;2182-2184.
    • (1997) Macromolecules , vol.30 , pp. 2182-2184
    • Elisseeff, J.1    Anseth, K.2    Langer, R.3    Hrkach, J.S.4
  • 9
    • 0345909485 scopus 로고    scopus 로고
    • Novel degradable poly(ethylene glycol) esters for drug-delivery
    • Crosslinked PEG-based hydrogels were formed by reaction of PEGs with more than two amine groups with PEGs with at least two N-hydroxysuccinimidyl-activated carboxyl termini. This crosslinking can be performed in situ, directly in the presence of living cells, because the leaving group, N-hydroxysuccinimide, has a very favorable toxicological profile.
    • Zhao X, Harris JM. Novel degradable poly(ethylene glycol) esters for drug-delivery. J Am Chem Soc Symp Ser. 680:1997;458-472 Crosslinked PEG-based hydrogels were formed by reaction of PEGs with more than two amine groups with PEGs with at least two N-hydroxysuccinimidyl-activated carboxyl termini. This crosslinking can be performed in situ, directly in the presence of living cells, because the leaving group, N-hydroxysuccinimide, has a very favorable toxicological profile.
    • (1997) J Am Chem Soc Symp Ser , vol.680 , pp. 458-472
    • Zhao, X.1    Harris, J.M.2
  • 10
    • 0032521332 scopus 로고    scopus 로고
    • Improved local-delivery of TGFβ-2 by binding to injectable fibrillar collagen via difunctional polyethylene-glycol
    • Difunctional N-hydroxysuccinimidyl activated carboxy PEGs were used to crosslink collagen in situ, and were used to chemically bind the growth factor TGFβ-2. This scheme may be useful for in situ crosslinking of protein solutions and suspensions in tissue defects and for providing controllable administration of the growth factor.
    • Bentz H, Schroeder J.A., Estridge T.D. Improved local-delivery of TGFβ-2 by binding to injectable fibrillar collagen via difunctional polyethylene-glycol. J Biomed Mater Res. 39:1998;539-548 Difunctional N-hydroxysuccinimidyl activated carboxy PEGs were used to crosslink collagen in situ, and were used to chemically bind the growth factor TGFβ-2. This scheme may be useful for in situ crosslinking of protein solutions and suspensions in tissue defects and for providing controllable administration of the growth factor.
    • (1998) J Biomed Mater Res , vol.39 , pp. 539-548
    • Bentz, H.1    Schroeder, J.A.2    Estridge, T.D.3
  • 11
    • 0031559845 scopus 로고    scopus 로고
    • Synthesis and characterization of enzymatically-cross-linked poly(ethylene glycol) hydrogels
    • Sperinde J.J., Griffith L.G. Synthesis and characterization of enzymatically-cross-linked poly(ethylene glycol) hydrogels. Macromolecules. 30:1997;5255-5264.
    • (1997) Macromolecules , vol.30 , pp. 5255-5264
    • Sperinde, J.J.1    Griffith, L.G.2
  • 12
    • 0026641052 scopus 로고
    • Antisense c-myb oligonucleotides inhibit intimal arterial smooth muscle cell accumulation in vivo
    • Simons M, Edelman E.R., DeKeyser J.L., Langer R, Rosenberg R.D. Antisense c-myb oligonucleotides inhibit intimal arterial smooth muscle cell accumulation in vivo. Nature. 359:1992;67-70.
    • (1992) Nature , vol.359 , pp. 67-70
    • Simons, M.1    Edelman, E.R.2    Dekeyser, J.L.3    Langer, R.4    Rosenberg, R.D.5
  • 13
    • 0001319478 scopus 로고    scopus 로고
    • Biodegradable block-copolymers as injectable drug-delivery systems
    • Block copolymers of PEG and polylactic acid were formed that exhibited an upper critical solution temperature. These materials formed liquids at 45°C and gels at body temperature. Thus, these degradable materials may be useful as injectable depots for drug delivery and matrices for tissue engineering.
    • Jeong B, Bae Y.H., Lee D.S., Kim S.W. Biodegradable block-copolymers as injectable drug-delivery systems. Nature. 388:1997;860-862 Block copolymers of PEG and polylactic acid were formed that exhibited an upper critical solution temperature. These materials formed liquids at 45°C and gels at body temperature. Thus, these degradable materials may be useful as injectable depots for drug delivery and matrices for tissue engineering.
    • (1997) Nature , vol.388 , pp. 860-862
    • Jeong, B.1    Bae, Y.H.2    Lee, D.S.3    Kim, S.W.4
  • 14
    • 0025881229 scopus 로고
    • 3-mediated fibroblast spreading and 140 nm for focal contact and stress fiber formation
    • 3-mediated fibroblast spreading and 140 nm for focal contact and stress fiber formation. J Cell Biol. 114:1991;1089-1100.
    • (1991) J Cell Biol , vol.114 , pp. 1089-1100
    • Massia, S.P.1    Hubbell, J.A.2
  • 15
    • 0027227425 scopus 로고
    • Maximal migration of human smooth muscle cells on fibronectin and type IV collagen occurs at an intermediate attachment strength
    • DiMilla P.A., Stone J.A., Quinn J.A., Albelda SM, Lauffenburger D.A. Maximal migration of human smooth muscle cells on fibronectin and type IV collagen occurs at an intermediate attachment strength. J Cell Biol. 122:1993;729-737.
    • (1993) J Cell Biol , vol.122 , pp. 729-737
    • Dimilla, P.A.1    Stone, J.A.2    Quinn, J.A.3    Albelda, S.M.4    Lauffenburger, D.A.5
  • 16
    • 8244221666 scopus 로고    scopus 로고
    • Characterization and development of RGD-peptide-modified poly(lactic acid-co-lysine) as an interactive, resorbable
    • Cook A.D., Hrkach J.S., Gao N.N., Johnson-IM, Pajvani U.B., Cannizzaro SM, Langer R. Characterization and development of RGD-peptide-modified poly(lactic acid-co-lysine) as an interactive, resorbable. J Biomed Mater Res. 35:1997;513-523.
    • (1997) J Biomed Mater Res , vol.35 , pp. 513-523
    • Cook, A.D.1    Hrkach, J.S.2    Gao, N.N.3    Johnson-Im4    Pajvani, U.B.5    Cannizzaro, S.M.6    Langer, R.7
  • 17
    • 0028176194 scopus 로고
    • N-acetylglucosamine and adenosine derivatized surfaces for cell-culture - 3T3 fibroblast and chicken hepatocyte response
    • Gutsche A.T., Parsons-Wingerter P, Chand D, Leong K.W. N-acetylglucosamine and adenosine derivatized surfaces for cell-culture - 3T3 fibroblast and chicken hepatocyte response. Biotechnol Bioeng. 43:1994;801-809.
    • (1994) Biotechnol Bioeng , vol.43 , pp. 801-809
    • Gutsche, A.T.1    Parsons-Wingerter, P.2    Chand, D.3    Leong, K.W.4
  • 18
    • 0028130107 scopus 로고
    • Polymer substrates for controlled biological interactions
    • Cima L.G. Polymer substrates for controlled biological interactions. J Cell Biochem. 56:1994;155-161.
    • (1994) J Cell Biochem , vol.56 , pp. 155-161
    • Cima, L.G.1
  • 20
    • 0032007690 scopus 로고    scopus 로고
    • Incorporation of adhesion peptides into nonadhesive hydrogels useful for tissue resurfacing
    • Hydrogels are presented that can be formed as thin coatings directly onto tissue surfaces after injury to block adhesive interactions, and methods are presented by which to incorporate adhesion peptides into this substrate. This may enable the adhesive signals presented by an injured tissue to be covered up and replaced with an engineered set of adhesive signals to yield a more favorable healing response.
    • Hern D.L., Hubbell J.A. Incorporation of adhesion peptides into nonadhesive hydrogels useful for tissue resurfacing. J Biomed Mater Res. 39:1998;266-276 Hydrogels are presented that can be formed as thin coatings directly onto tissue surfaces after injury to block adhesive interactions, and methods are presented by which to incorporate adhesion peptides into this substrate. This may enable the adhesive signals presented by an injured tissue to be covered up and replaced with an engineered set of adhesive signals to yield a more favorable healing response.
    • (1998) J Biomed Mater Res , vol.39 , pp. 266-276
    • Hern, D.L.1    Hubbell, J.A.2
  • 21
  • 22
    • 0029074170 scopus 로고
    • Laminin oligopeptide derivatized agarose gels allow 3-dimensional neurite extension in-vitro
    • Bellamkonda R, Ranieri J.P., Aebischer P. Laminin oligopeptide derivatized agarose gels allow 3-dimensional neurite extension in-vitro. J Neurosci Res. 41:1995;501-509.
    • (1995) J Neurosci Res , vol.41 , pp. 501-509
    • Bellamkonda, R.1    Ranieri, J.P.2    Aebischer, P.3
  • 23
    • 15844382102 scopus 로고    scopus 로고
    • Fibroblast aggregation by suspension with conjugates of poly(ethylene glycol) and RGD
    • Dai W.G., Saltzman WM. Fibroblast aggregation by suspension with conjugates of poly(ethylene glycol) and RGD. Biotechnol Bioeng. 50:1996;349-356.
    • (1996) Biotechnol Bioeng , vol.50 , pp. 349-356
    • Dai, W.G.1    Saltzman, W.M.2
  • 24
    • 0028031576 scopus 로고
    • Cell-binding peptides conjugated to poly(ethylene glycol) promote neural cell-aggregation
    • Dai W.G., Belt J, Saltzman WM. Cell-binding peptides conjugated to poly(ethylene glycol) promote neural cell-aggregation. Bio/Technology. 12:1994;797-801.
    • (1994) Bio/Technology , vol.12 , pp. 797-801
    • Dai, W.G.1    Belt, J.2    Saltzman, W.M.3
  • 25
    • 0029791838 scopus 로고    scopus 로고
    • Tethered epidermal growth factor as a paradigm for growth factor-induced stimulation from the solid phase
    • The polypeptide growth factor, epidermal growth factor, was chemically coupled to the surfaces of polymeric biomaterials via a long PEG linker and was found to be biologically active when surface-bound. This may provide for much more controllable growth factor delivery schemes for tissue regeneration and healing.
    • Kuhl R.P., Griffith-Cima L. Tethered epidermal growth factor as a paradigm for growth factor-induced stimulation from the solid phase. Nature Med. 2:1996;1022-1027 The polypeptide growth factor, epidermal growth factor, was chemically coupled to the surfaces of polymeric biomaterials via a long PEG linker and was found to be biologically active when surface-bound. This may provide for much more controllable growth factor delivery schemes for tissue regeneration and healing.
    • (1996) Nature Med , vol.2 , pp. 1022-1027
    • Kuhl, R.P.1    Griffith-Cima, L.2
  • 26
    • 84988214154 scopus 로고
    • Degradability of hydrogels containing azoaromatic cross-links
    • Yeh P.Y., Kopeckova P, Kopecek J. Degradability of hydrogels containing azoaromatic cross-links. Macromol Chem Phys. 196:1995;2183-2202.
    • (1995) Macromol Chem Phys , vol.196 , pp. 2183-2202
    • Yeh, P.Y.1    Kopeckova, P.2    Kopecek, J.3
  • 27
    • 0029339453 scopus 로고
    • Enantioselective release of 5-fluorouracil from N-(2-hydroxypropyl)methacrylamide-based copolymers via lysosomal-enzymes
    • Putnam D, Kopecek J. Enantioselective release of 5-fluorouracil from N-(2-hydroxypropyl)methacrylamide-based copolymers via lysosomal-enzymes. Bioconjug Chem. 6:1995;483-492.
    • (1995) Bioconjug Chem , vol.6 , pp. 483-492
    • Putnam, D.1    Kopecek, J.2
  • 28
    • 0031984289 scopus 로고    scopus 로고
    • Integration of surface modification and 3D fabrication techniques to prepare patterned poly(l-lactide) substrates allowing regionally selective cell-adhesion
    • Park A, Wu B, Griffith L.G. Integration of surface modification and 3D fabrication techniques to prepare patterned poly(l-lactide) substrates allowing regionally selective cell-adhesion. J Biomater Sci Polym Ed. 9:1998;89-110.
    • (1998) J Biomater Sci Polym Ed , vol.9 , pp. 89-110
    • Park, A.1    Wu, B.2    Griffith, L.G.3
  • 29
    • 0031025844 scopus 로고    scopus 로고
    • 1H-NMR spectroscopy
    • Block copolymers of PEG and polylactic acid were formed and conditions that led to self-assembly into nanoparticles were identified. These particles circulated much longer in animal models with intravascular administration than did polylactic acid nanoparticles of the same size.
    • 1H-NMR spectroscopy. Biomaterials. 18:1997;27-30 Block copolymers of PEG and polylactic acid were formed and conditions that led to self-assembly into nanoparticles were identified. These particles circulated much longer in animal models with intravascular administration than did polylactic acid nanoparticles of the same size.
    • (1997) Biomaterials , vol.18 , pp. 27-30
    • Hrkach, J.S.1    Peracchia, M.T.2    Domb, A.3    Lotan, N.4    Langer, R.5
  • 30
    • 0042547460 scopus 로고    scopus 로고
    • Design of functional polymeric micelles as site-specific drug vehicles based on poly(α-hydroxy ethylene oxide-co-benzyl L-aspartate) block-copolymers
    • Block copolymers that spontaneously form polymeric micelles in water were developed. These materials possess a hydrophobic core, which is useful for containing hydrophobic drugs; and the hydrophilic PEG corona slows the rate of clearance of these polymeric micelle delivery forms from the circulation.
    • Cammas S, Okano T, Sakurai Y, Kataoka K. Design of functional polymeric micelles as site-specific drug vehicles based on poly(α-hydroxy ethylene oxide-co-benzyl L-aspartate) block-copolymers. Mater Sci Eng C. 4:1997;241-247 Block copolymers that spontaneously form polymeric micelles in water were developed. These materials possess a hydrophobic core, which is useful for containing hydrophobic drugs; and the hydrophilic PEG corona slows the rate of clearance of these polymeric micelle delivery forms from the circulation.
    • (1997) Mater Sci Eng C , vol.4 , pp. 241-247
    • Cammas, S.1    Okano, T.2    Sakurai, Y.3    Kataoka, K.4
  • 31
    • 0031646316 scopus 로고    scopus 로고
    • Novel polyion complex micelles entrapping enzyme molecules in the core - Preparation of narrowly-distributed micelles from lysozyme and poly(ethylene glycol)-poly(aspartic acid) block-copolymer in aqueous-medium.
    • Block copolymers were developed that are conceptually similar to those of the previous reference [30], although they possess an ionic core, for binding in the core of the resulting polymeric micelles drugs of opposite charge. These materials are particularly useful for the delivery of DNA or antisense oligonucleotides.
    • Harada A, Kataoka K. Novel polyion complex micelles entrapping enzyme molecules in the core - preparation of narrowly-distributed micelles from lysozyme and poly(ethylene glycol)-poly(aspartic acid) block-copolymer in aqueous-medium. Macromolecules. 31:1998;288-294 Block copolymers were developed that are conceptually similar to those of the previous reference [30], although they possess an ionic core, for binding in the core of the resulting polymeric micelles drugs of opposite charge. These materials are particularly useful for the delivery of DNA or antisense oligonucleotides.
    • (1998) Macromolecules , vol.31 , pp. 288-294
    • Harada, A.1    Kataoka, K.2
  • 32
    • 0031938986 scopus 로고    scopus 로고
    • Remarkable increase in nuclease resistance of plasmid DNA through supramolecular assembly with poly(ethylene glycol) poly(L-lysine) block-copolymer
    • Block copolymers of PEG with the polycation polylysine were used in the delivery of DNA. The polycation domain was found to effectively condense the DNA, and the PEG chains were observed to protect the bound DNA from enzymatic degradation by DNAses in solution, presumably by steric stabilization.
    • Katayose S, Kataoka K. Remarkable increase in nuclease resistance of plasmid DNA through supramolecular assembly with poly(ethylene glycol) poly(L-lysine) block-copolymer. J Pharm Sci. 87:1998;160-163 Block copolymers of PEG with the polycation polylysine were used in the delivery of DNA. The polycation domain was found to effectively condense the DNA, and the PEG chains were observed to protect the bound DNA from enzymatic degradation by DNAses in solution, presumably by steric stabilization.
    • (1998) J Pharm Sci , vol.87 , pp. 160-163
    • Katayose, S.1    Kataoka, K.2
  • 33
    • 1842373831 scopus 로고    scopus 로고
    • Molecular manipulation of microstructures - biomaterials, ceramics, and semiconductors
    • Stupp SI, Braun PV. Molecular manipulation of microstructures - biomaterials, ceramics, and semiconductors. Science. 277:1997;1242-1248.
    • (1997) Science , vol.277 , pp. 1242-1248
    • Stupp, S.I.1    Braun, P.V.2
  • 35
    • 0028967709 scopus 로고
    • Nanoapatite and organoapatite implants in bone - Histology and ultrastructure of the interface
    • Mullermai CM, Stupp SI, Voigt C, Gross U. Nanoapatite and organoapatite implants in bone - histology and ultrastructure of the interface. J Biomed Mater Res. 29:1995;9-18.
    • (1995) J Biomed Mater Res , vol.29 , pp. 9-18
    • Mullermai, C.M.1    Stupp, S.I.2    Voigt, C.3    Gross, U.4
  • 36
    • 0028917333 scopus 로고
    • Placebo-controlled trial of safety and efficacy of intraoperative controlled delivery by biodegradable polymers of chemotherapy for recurrent gliomas
    • Brem H, Piantadosi S, Burger PC, Walker M, Selker R, Vick N.A., Black K, Sisti M, Brem S, Mohr G, et al. Placebo-controlled trial of safety and efficacy of intraoperative controlled delivery by biodegradable polymers of chemotherapy for recurrent gliomas. Lancet. 345:1995;1008-1012.
    • (1995) Lancet , vol.345 , pp. 1008-1012
    • Brem, H.1    Piantadosi, S.2    Burger, P.C.3    Walker, M.4    Selker, R.5    Vick, N.A.6    Black, K.7    Sisti, M.8    Brem, S.9    Mohr, G.10
  • 38
    • 0028484475 scopus 로고
    • Evaluation of a series of tyrosine-derived polycarbonates as degradable biomaterials
    • Ertel SI, Kohn J. Evaluation of a series of tyrosine-derived polycarbonates as degradable biomaterials. J Biomed Mater Res. 28:1994;919-930.
    • (1994) J Biomed Mater Res , vol.28 , pp. 919-930
    • Ertel, S.I.1    Kohn, J.2
  • 40
    • 0032520855 scopus 로고    scopus 로고
    • Degradable and highly porous polyesterurethane foam as biomaterial - Effects and phagocytosis of degradation products in osteoblasts
    • Saad B, Ciardelli G, Matter S, Welti M, Uhlschmid G.K., Neuenschwander P, Suter U.W. Degradable and highly porous polyesterurethane foam as biomaterial - effects and phagocytosis of degradation products in osteoblasts. J Biomed Mater Res. 39:1998;594-602.
    • (1998) J Biomed Mater Res , vol.39 , pp. 594-602
    • Saad, B.1    Ciardelli, G.2    Matter, S.3    Welti, M.4    Uhlschmid, G.K.5    Neuenschwander, P.6    Suter, U.W.7
  • 41
    • 0031195265 scopus 로고    scopus 로고
    • Development of degradable polyesterurethanes for medical applications - In-vitro and in-vivo evaluations
    • Phase segregated multiblock copolymeric elastomers are introduced, comprised of polyhydroxybutyrate hard segments and polylactic acid soft segments. These materials represent a new class of degradable elastomers, the degradative and mechanical properties of which can readily be manipulated.
    • Saad B, Hirt T.D., Welti M, Uhlschmid G.K., Neuenschwander P, Suter U.W. Development of degradable polyesterurethanes for medical applications - in-vitro and in-vivo evaluations. J Biomed Mater Res. 36:1997;65-74 Phase segregated multiblock copolymeric elastomers are introduced, comprised of polyhydroxybutyrate hard segments and polylactic acid soft segments. These materials represent a new class of degradable elastomers, the degradative and mechanical properties of which can readily be manipulated.
    • (1997) J Biomed Mater Res , vol.36 , pp. 65-74
    • Saad, B.1    Hirt, T.D.2    Welti, M.3    Uhlschmid, G.K.4    Neuenschwander, P.5    Suter, U.W.6


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