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Difunctional N-hydroxysuccinimidyl activated carboxy PEGs were used to crosslink collagen in situ, and were used to chemically bind the growth factor TGFβ-2. This scheme may be useful for in situ crosslinking of protein solutions and suspensions in tissue defects and for providing controllable administration of the growth factor.
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Bentz H, Schroeder J.A., Estridge T.D. Improved local-delivery of TGFβ-2 by binding to injectable fibrillar collagen via difunctional polyethylene-glycol. J Biomed Mater Res. 39:1998;539-548 Difunctional N-hydroxysuccinimidyl activated carboxy PEGs were used to crosslink collagen in situ, and were used to chemically bind the growth factor TGFβ-2. This scheme may be useful for in situ crosslinking of protein solutions and suspensions in tissue defects and for providing controllable administration of the growth factor.
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Block copolymers of PEG and polylactic acid were formed that exhibited an upper critical solution temperature. These materials formed liquids at 45°C and gels at body temperature. Thus, these degradable materials may be useful as injectable depots for drug delivery and matrices for tissue engineering.
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Hydrogels are presented that can be formed as thin coatings directly onto tissue surfaces after injury to block adhesive interactions, and methods are presented by which to incorporate adhesion peptides into this substrate. This may enable the adhesive signals presented by an injured tissue to be covered up and replaced with an engineered set of adhesive signals to yield a more favorable healing response.
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Hern D.L., Hubbell J.A. Incorporation of adhesion peptides into nonadhesive hydrogels useful for tissue resurfacing. J Biomed Mater Res. 39:1998;266-276 Hydrogels are presented that can be formed as thin coatings directly onto tissue surfaces after injury to block adhesive interactions, and methods are presented by which to incorporate adhesion peptides into this substrate. This may enable the adhesive signals presented by an injured tissue to be covered up and replaced with an engineered set of adhesive signals to yield a more favorable healing response.
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