The p3 peptide, a naturally occurring fragment of the amyloid-β peptide (Aβ) found in Alzheimer's disease, has a greater aggregation propensity in vitro than full-length Aβ, but does not bind Cu2+

Australian Journal of Chemistry

Volumn 53, Issue 4, 2000, Pages 321-326

  Ali, Feda ^a   Thompson, Andrew J ^a   Barrow, Colin J ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Circular dichroism; Copper binding; Electrospray mass spectrometry; Peptide synthesis; helix; sheet

Indexed keywords

EID: 0001062933     PISSN: 00049425     EISSN: None     Source Type: Journal    
DOI: 10.1071/ch99169     Document Type: Article

References (18)

1. Tanzi, R. E., Ann. Med., 1989, 21, 91.
2. Selkoe, D. J., Neuron, 1991, 6, 487.
3. Griffin, W. S. T., Sheng, J. G., Roberts, G. W., and Mrak, R. E., J. Neuropath. Exp. Neurol., 1995, 54, 276.
4. Esiri, M. M., Hyman, B. T., Beyreuther, K, and Masters, C. L., 'Ageing and Dementia' in 'Greenfields Neuropathology' (Eds D. I. Graham and P. L. Lantos) 6th Edn, Vol. 2, pp. 153-233 (Arnold: London 1966).
5. Higgins, L. S., Murphy, G. M., Jr, Forno, L. S., Catalano, R., and Cordell, B., Am. J. Pathol., 1996, 149, 585.
6. Iwatsubo, T., Saido, T. C., Mann, D. M., Lee V. M., and Trojanowski, J. Q., Am. J. Pathol., 1996, 149, 1823.
7. Thal, D. R., Sassin, I., Schultz, C., Haass, C., Braak, E., and Braak, H., J. Neuropath. Exp. Neurol. 1999, 58, 210.
8. Evin, G., Beyreuther, K, and Masters, C. L., Amyloid: Int. J. Exp. Clin. Invest., 1994, 1, 885.
9. Selkoe, D. J., Annu. Rev. Cell Biol., 1994, 10, 373.
10. Lichtenthaler, S. F., Ida, N., Multhaup, G., Masters, C. L., and Beyreuther, K., Biochemistry, 1997, 36, 15396.
11. Wisniewski, H. M., Wegiel, J., and Kotula, L., Neuropathol. Appl. Neurobiol., 1996, 22, 3.
12. Selkoe, D. J., Trends Neurosci., 1993, 16, 403.
13. Mullan, M., and Crawford, F., Trends Neurosci., 1993, 16, 398.
14. Pike, G. J., Walencewicz, A. J., Glabe, C. G., and Cotman, C. W., Brain Res., 1991, 563, 311.
15. Pike, C. J., Burdick, D., Walencewicz, A. J., Glabe, C. G., and Cotman, C. W., J. Neurosci., 1993, 13, 1676.
16. Yankner, B. A., Neurobiol. Aging, 1992, 13, 615.
17. Walsh, D. M., Lomakin, A., Benedek, G B., Condron, M. M., and Teplow, D. B., J. Biol. Chem., 1997, 272, 22364.
18. Harper, J. D., Wong, S. S., Lieber, C. M., and Lansbury, P. T., Jr, Chem. Biol., 1997, 4, 119.