Stability of the Four 2-(p-nitrobenzyl)-trans-CyDTPA 88Y Complexes

Radiochimica Acta

Volumn 79, Issue 2, 1997, Pages 123-126

  Wu, C ^a   Brechbiel, Martin W ^a   Gansow, Otto A ^a   Kobayashi, H ^b   Carrasquillo, J ^b   Pastan, I ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b CC ^*  (United States)

Author keywords

Antibodies; Chelates; Radioimmunotherapy; Stereochemistry; Yttrium

Indexed keywords

EID: 0000929919     PISSN: 00338230     EISSN: None     Source Type: Journal    
DOI: 10.1524/ract.1997.79.2.123     Document Type: Article

References (13)

1. Proceedings of the Sixth Conference on Radioimmunodetection and Radioimmunotherapy of Cancer, In: Tumor Targeting, 2, 127 (1996) (A. Epenetos, ed.), (Entire Journal Issue).
2. Srivastava, S. C., Mease, R. C.: Progress in Research on Ligands, Nuclides and Techniques for Labeling Monoclonal Antibodies. Nucl. Med. Biol. 18, 589 (1991).
3. Jankowski, K. J., Parker, D.: Diagnosis and Therapy with antibody Conjugates of Metal Radioisotopes. In: Advances in Metals in Medicine, Vol. 1 (M. J. Abrams, B. A. Murrer, eds.) JAI Press Inc. 1993, p. 29.
4. 212Bi for α-Particle Mediated Radioimmunotherapy. J. Chem. Soc., Chem. Commun., 1169 (1991).
5. 212Bi Alpha-particle Emitter. J. Chem. Soc., Perkin Trans. 1, 1173 (1992).
6. Huneke, R. B., Pippin, C. G., Squire, R. A., Brechbiel, M. W., Gansow, O. A., Strand, M.: Effective α-Particle-mediated Radioimmunotherapy of Murine Leukemia. Cancer Res. 52, 5818 (1992).
7. Camera, L., Kinuya, S., Garmestani, K., Wu, C., Brechbiel, M. W., Pai, L., McMurry, T. J., Gansow, O. A., Pastan, I., Paik, C. H., Carrasquillo, J. A.: Evaluation of the Serum Stability and In Vivo Biodistribution of the 2-(p-isothiocyanatobenzyl)-cyclohexyl-DTPA (CHX-DTPA) and Other Ligands for Yttrium-Labeling of Monoclonal Antibodies. J. Nucl. Med. 35, 882 (1994).
8. Pastan, I., Lovelace, E. T., Gallo, M. G., Rutherford, A. V., Magnani, J. L., Willingham, M. C.: Characterization of Monoclonal antibodies B1 and B3 That React with Mutinous Adenocarcinomas. Cancer Res. 51, 3781 (1991).
9. Wu, C., Kobayashi, H., Sun, B., Yoo, T. M., Paik, C. H., Gansow, O. A., Carrasquillo, J. A., Pastan, I., Brechbiel, M. W.: Stereochemical Influence on the Stability of Radio-Metal Complexes in Vivo. Synthesis and Evaluation of the Four Stereoisomers of 2-(p-nitrobenzyl)-trans-CyDTPA. Bioorg. Med. Chem. (in press).
10. Mirzadeh, S., Brechbiel, M. W., Atcher, R., Gansow, O. A.: Radiomctal Labeling of Immunoproteins: Covalent Linkage of 2-(4-Isotheiocyanatobenzyl)diethylenetriaminepenta- acetic Acid Ligand to Immunoglobulin. Bioconjugate Chem. 1, 59-65 (1990).
11. Pippin, C. G., Parker, T. A., McMurry, T. J., Brechbiel, M. W.: Spectrophotometric Method for the Determination of a Bifunctional DTPA ligand in DTPA-Monoclonal Antibody Conjugates. Bioconjugate Chem. 3, 342-345 (1992).
12. 111In-Labeled B3 Monoclonal Antibody: Biodistribution and Imaging Studies in Nude Mice Bearing Human Epidermoid Carcinoma Xenografts. Cancer Res. 53, 2834-2839 (1993).
13. Durbin, P. W.: Metabolic Characteristics within a Chemical Family. Health Phys. 2, 225-238 (1960).