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Volumn 3, Issue SUPPL.5, 2001, Pages

Results of phase I/II clinical trials with ezetimibe, a novel selective cholesterol absorption inhibitor

Author keywords

Cholesterol absorption inhibitor; Ezetimibe; Hypercholesterolaemia; Pharmacokinetic pharmacodynamic; Phase II studies; Statins

Indexed keywords


EID: 0000801934     PISSN: 1520765X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1520-765X(01)90107-5     Document Type: Article
Times cited : (77)

References (11)
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  • 2
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    • Comparison of the activity and disposition of the novel cholesterol absorption inhibitor, SCH58235, and its glucuronide, SCH60663
    • van Heek M, Farley C, Compton DS et al. Comparison of the activity and disposition of the novel cholesterol absorption inhibitor, SCH58235, and its glucuronide, SCH60663. Br J Pharmacol 2000; 129: 1748-54.
    • (2000) Br J Pharmacol , vol.129 , pp. 1748-1754
    • Van Heek, M.1    Farley, C.2    Compton, D.S.3
  • 3
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    • Summary of the Second Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II)
    • Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Summary of the Second Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II). J Am Med Assoc 1993; 269: 3015-23.
    • (1993) J Am Med Assoc , vol.269 , pp. 3015-3023
  • 4
    • 0001405466 scopus 로고    scopus 로고
    • Low-density lipoprotein cholesterol reduction by SCH 58235 (ezetimibe), a novel inhibitor of cholesterol absorption, in 243 hypercholesterolemic subjects: Results of a dose-response study
    • Bays H, Drehobl M, Rosenblatt S et al. Low-density lipoprotein cholesterol reduction by SCH 58235 (ezetimibe), a novel inhibitor of cholesterol absorption, in 243 hypercholesterolemic subjects: results of a dose-response study (Abstr). Atherosclerosis 2000; 151: 133.
    • (2000) Atherosclerosis , vol.151 , pp. 133
    • Bays, H.1    Drehobl, M.2    Rosenblatt, S.3
  • 5
    • 0000113773 scopus 로고    scopus 로고
    • Reduction of LDL-cholesterol and elevation of HDL-cholesterol in subjects with primary hypercholesterolemia by ezetimibe (SCH 58235): Pooled analysis of two phase II studies
    • Lipka LJ, LeBeaut AP, Veltri EP et al. Reduction of LDL-cholesterol and elevation of HDL-cholesterol in subjects with primary hypercholesterolemia by ezetimibe (SCH 58235): pooled analysis of two phase II studies (Abstr). J Am Coll Cardiol 2000; 35 (Suppl 2A): 257A.
    • (2000) J Am Coll Cardiol , vol.35 , Issue.SUPPL. 2A
    • Lipka, L.J.1    LeBeaut, A.P.2    Veltri, E.P.3
  • 6
    • 0003114101 scopus 로고    scopus 로고
    • Pharmacodynamic interaction between the new selective cholesterol absorption inhibitor SCH 58235 and simvastatin
    • Kosoglou T, Meyer I, Musiol B et al. Pharmacodynamic interaction between the new selective cholesterol absorption inhibitor SCH 58235 and simvastatin (Abstr). Atherosclerosis 2000; 151: 135.
    • (2000) Atherosclerosis , vol.151 , pp. 135
    • Kosoglou, T.1    Meyer, I.2    Musiol, B.3
  • 7
    • 0001472804 scopus 로고    scopus 로고
    • Ezetimibe (SCH 58235) does not affect the pharmacokinetics of simvastatin
    • Statkevich P, Zhu Y, Kosoglou T et al. Ezetimibe (SCH 58235) does not affect the pharmacokinetics of simvastatin (Abstr). Clin Pharmacol Ther 2000; 67: 146.
    • (2000) Clin Pharmacol Ther , vol.67 , pp. 146
    • Statkevich, P.1    Zhu, Y.2    Kosoglou, T.3
  • 8
    • 0033549840 scopus 로고    scopus 로고
    • Drug treatment of lipid disorders
    • Knopp RH. Drug treatment of lipid disorders. N Engl J Med 1999; 341: 498-511.
    • (1999) N Engl J Med , vol.341 , pp. 498-511
    • Knopp, R.H.1
  • 11
    • 0001584541 scopus 로고    scopus 로고
    • Effect of ezetimibe (SCH 58235) on the activity of drug metabolizing enzymes in vivo
    • Zhu Y, Statkevich P, Kosoglou T et al. Effect of ezetimibe (SCH 58235) on the activity of drug metabolizing enzymes in vivo (Abstr). Clin Pharmacol Ther 2000; 67: 152.
    • (2000) Clin Pharmacol Ther , vol.67 , pp. 152
    • Zhu, Y.1    Statkevich, P.2    Kosoglou, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.