Cloning of Isopenicillin N Synthese Gene from Lysobacter lactamgenus

Journal of Microbiology and Biotechnology

Volumn 7, Issue 6, 1997, Pages 373-377

  Ryu, Jae Kook ^a   Nam, Doo Hyun ^a  

^a Yeungnam University   (South Korea)

Author keywords

lactam antibiotic; Cyclase; Gene cloning; Isopenicillin N synthase; Lysobacter lactamgenus

Indexed keywords

EID: 0000671472     PISSN: 10177825     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Baldwin, J. E. 1990. The biosynthesis of penicillins and cephalosporins. J. Heterocyclic Chem. 27: 71-78.
2. Barredo, J. L., J. M. Cantoral, E. Alvarez, B. Diez, and J. F. Martin. 1989. Cloning, sequence analysis and transcriptional study of the isopenicillin N synthase of Penicillium chrysogenum AS-P-78. Mol. Gen. Genet. 216: 91-98.
3. Carr, L. G., P. L. Skaturd, M. E. Scheetz, S. W. Queener, and T. D. Ingolia. 1986. Cloning and expression of the isopenicillin N synthetase gene from Penicillium chrysogenum. Gene 48: 257-266.
4. Demain, A. L. and S. Wolf. 1987. Biosynthesis of cephalosporins. Develop. Ind. Microbiol. 27: 175-182.
5. Harada, S., S. Tsubotani, H. Ono, and H. Okazaki. 1984. Cephabacins, new cephem antibiotics of bacterial origin. II. isolation and characterization. J. Antibiot. 37: 1536-1545.
6. Jensen, S. E. 1986. Biosynthesis of β-lactam antibiotics. Crit. Rev. Biotechnol. 3: 277-301.
7. Jensen, S. E., D. W. S. Westlake, and S. Wolfe. 1982. High performance liquid Chromatographic assay of cyclization activity in cell-free systems from Streptomyces clavuligerus. J. Antibiot. 35: 1026-1032.
8. Jensen, S. E., D. W. S. Westlake, R. J. Bowers, L. Lyu- brchansky, and S. Wolfe. 1986. Synthesis of benzylpenicillin by cell-free extracts from Streptomyces clavuligerus. J. Antibiot. 39: 822-826.
9. Kakizono, T. and D. D. Y. Ryu. 1990. Penicillin biosynthesis and isopenicillin N synthetase activity in Lysobacter lactamgenus IFO 14288. Ann. New York Acad. Sci. 217: 207-215.
10. Leskiw, B. K., Y. Aharonowitz, M. Mevarech, S. Wolfe, L. C. Vining, D. W. S. Westlake, and S. E. Jensen. 1988. Cloning and nucleotide sequence determination of the IPNS gene from S. clavuligerus. Gene 62: 187-196
11. Modesta G. D., P. Liras, and J. F. Martin. 1991. Cloning and characterization of the isopenicillin N synthase gene of Streptomyces griseus NRRL 3851 and studies of expression and complementation of the cephamycin pathway in Streptomyces clavuligerus. Antimicrob. Agents Chemother. 35: 44-52.
12. Nüesch, J., J. Heim, and H.-J. Treicher. 1987. The biosynthesis of sulfur-containing β-lactam antibiotics. Ann. Rev. Microbiol. 41: 51-75.
13. Ono, H., Y. Nozaki, N. Katayama, and H. Okazaki. 1984. Cephabacins, new cephem antibiotics of bacterial origin. I. Discovery and taxonomy of the producing organisms and fermentation. J. Antibiot. 37: 1528-1535.
14. Ramon, D., I. Carramolino, C. Patino, F. Sanchez, and M. A. Penalva. 1987. Cloning and characterization of the isopenicillin N synthetase gene mediating the formation of the β-lactam ring in Aspergillus nidulams. Gene 57: 171-181.
15. Riggs, P., F. M. Ausebet, D. M. Coen, and S. J. Scharf. 1990. Current protocols in molecular biology, vol. 15, John Wiley & Sons, N.Y.
16. Roh, J. W. and D. H. Nam. 1992. Biosynthesis of β-lactam antibiotics by cell-free extract from Lysobacter lactamgenus. Arch. Pharm. Res. 15: 234-238.
17. Roh, J. W., J. H. Bang, and D. H. Nam. 1992. Nutritional requirements of Lysobacter lactamgenus for the production of cephabacins. Biotechnol. Lett. 14: 455-460.
18. Ruis, N. and A. L. Demain. 1997. Lysine ε-aminotransferase, the initial enzyme of cephalosporin biosynthesis in actinomycetes. J. Microbiol. Biotechnol. 7: 95-100.
19. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual. Cold Spring Harbor. N. Y.
20. Samson, S. M., R. Belagaje, D. T. Blankenship, J. L. Chapman, D, Perry, P. L. Skatrud, R. M. VanFrank, E. P. Abraham, J. E. Baldwin, S. W. Queener, and T. D. Ingolia. 1985. Isolation, sequence determination and expression in Escherichia coli of the isopenicillin N synthetase gene from Cephalosporium acremonium. Nature 318: 191-194.
21. Shiftman, D., G. Cohen, Y. Aharonowitz, H. von Dohren, H. Kleinkauf, and M. Mevarech. 1990. Nucleotide sequence of the isopenicillin N synthase gene (pcbC) of the gram negative Flavobacterium sp. SC12, 154. Nucleic Acid Res. 18: 660.
22. Shiffman, D., M. Mevarech, S. E. Jensen, G. Cohen, and Y. Aharonowitz. 1988. Cloning and comparative sequence analysis of the gene cloning for isopenicillin N synthase in Streptomyces. Mol. Gen. Genet. 214: 562-569.