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Volumn 7, Issue 2, 1997, Pages 95-100

Lysine ∈-Aminotransferase, the Initial Enzyme of Cephalosporin Biosynthesis in Actinomycetes

Author keywords

Actinomycetes; Cephalosponn; Lysine aminotransferase

Indexed keywords

AMINOTRANSFERASE; AMMONIUM CHLORIDE; CARBON; CEPHALOSPORIN DERIVATIVE; LACTAM; LYSINE; LYSINE 6 AMINOTRANSFERASE; PHOSPHATE;

EID: 0031107884     PISSN: 10177825     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (12)

References (38)
  • 1
    • 0017661481 scopus 로고
    • Influence of inorganic phosphate and organic buffers on cephalosporin production by Streptomyces clavuligerus
    • Aharonowitz, Y. and A. L. Demain. 1977. Influence of inorganic phosphate and organic buffers on cephalosporin production by Streptomyces clavuligerus. Arch. Microbiol. 115: 169-173.
    • (1977) Arch. Microbiol. , vol.115 , pp. 169-173
    • Aharonowitz, Y.1    Demain, A.L.2
  • 2
    • 0017886045 scopus 로고
    • Carbon catabolite regulation of cephalosporin production in Streptomyces clavuligerus
    • Aharonowitz, Y. and A. L. Demain. 1978. Carbon catabolite regulation of cephalosporin production in Streptomyces clavuligerus. Antimicrob. Agents Chemother. 14: 159-164.
    • (1978) Antimicrob. Agents Chemother. , vol.14 , pp. 159-164
    • Aharonowitz, Y.1    Demain, A.L.2
  • 3
    • 0025771057 scopus 로고
    • Stringent response and initiation of secondary metabolism in Streptomyces clavuligerus
    • 2a. Bascarán, V., L. Sánchez, C. Hardisson, and A. F. Braña, 1991 Stringent response and initiation of secondary metabolism in Streptomyces clavuligerus. J. Gen. Microbiol. 137: 1625-1634.
    • (1991) J. Gen. Microbiol. , vol.137 , pp. 1625-1634
    • Bascarán, V.1    Sánchez, L.2    Hardisson, C.3    Braña, A.F.4
  • 4
    • 0025951613 scopus 로고
    • A gene encoding lysine α-aminotransferase, which forms the β-lactam precursor α-aminoadipic acid, is located in the cluster of cephamycin biosynthetic genes in Nocardia lactamdurans
    • Coque J. J. R., P. Liras, L. Laiz, and J. F. Martin. 1991. A gene encoding lysine α-aminotransferase, which forms the β-lactam precursor α-aminoadipic acid, is located in the cluster of cephamycin biosynthetic genes in Nocardia lactamdurans. J. Bacteriol. 173: 6258-6264.
    • (1991) J. Bacteriol. , vol.173 , pp. 6258-6264
    • Coque, J.J.R.1    Liras, P.2    Laiz, L.3    Martin, J.F.4
  • 5
    • 0028290725 scopus 로고
    • Interdependence of gene expression for early steps of cephalosporin synthesis in Streptomyces clavuligerus
    • Demain, A. L., J. M. Piret, H. Yu, J.-J. R. Coque, P. Liras, and J. F. Martin. 1994. Interdependence of gene expression for early steps of cephalosporin synthesis in Streptomyces clavuligerus. Ann. N.Y. Acad. Sci 721: 117-122.
    • (1994) Ann. N.Y. Acad. Sci 721 , pp. 117-122
    • Demain, A.L.1    Piret, J.M.2    Yu, H.3    Coque, J.-J.R.4    Liras, P.5    Martin, J.F.6
  • 6
    • 0029917217 scopus 로고    scopus 로고
    • Unexpected enhancement of β-lactam antibiotic formation in Streptomyces clavuligerus by very high concentrations of exogenous lysine
    • Fang, A., P. Keables, and A. L. Demain. 1996. Unexpected enhancement of β-lactam antibiotic formation in Streptomyces clavuligerus by very high concentrations of exogenous lysine. Appl. Microbiol. Biotechnol. 44: 705-709.
    • (1996) Appl. Microbiol. Biotechnol. , vol.44 , pp. 705-709
    • Fang, A.1    Keables, P.2    Demain, A.L.3
  • 7
    • 0021408594 scopus 로고
    • Carbon source regulation of cephem antibiotic production by resting cells of Streptomyces clavuligerus and its reversal by protein synthesis inhibitors
    • Hu, W.-S., A. F. Braña, and A. L. Demain. 1984. Carbon source regulation of cephem antibiotic production by resting cells of Streptomyces clavuligerus and its reversal by protein synthesis inhibitors. Enzyme Microb. Technol. 6: 155-160.
    • (1984) Enzyme Microb. Technol. , vol.6 , pp. 155-160
    • Hu, W.-S.1    Braña, A.F.2    Demain, A.L.3
  • 8
    • 0018909597 scopus 로고
    • L-lysine ∈aminotransferase involved in cephamycin C synthesis in Streptomyces lactamdurans
    • Kern, B. A., D. Hendlin, and E. Inamine. 1980. L-lysine ∈aminotransferase involved in cephamycin C synthesis in Streptomyces lactamdurans. Antimicrob. Agents Chemother. 17: 679-685.
    • (1980) Antimicrob. Agents Chemother. , vol.17 , pp. 679-685
    • Kern, B.A.1    Hendlin, D.2    Inamine, E.3
  • 9
    • 0024535307 scopus 로고
    • Cloning, characterization, and expression in Escherichia coli of the Streptomyces clavuligerus gene encoding deacetoxycephalosporin C synthetase
    • Kovacevic, S., B. J. Weigel, M. B. Tobin, T. D. Ingolia, and J. R. Miller. 1989. Cloning, characterization, and expression in Escherichia coli of the Streptomyces clavuligerus gene encoding deacetoxycephalosporin C synthetase. J. Bacteriol. 171: 754-760.
    • (1989) J. Bacteriol. , vol.171 , pp. 754-760
    • Kovacevic, S.1    Weigel, B.J.2    Tobin, M.B.3    Ingolia, T.D.4    Miller, J.R.5
  • 10
    • 0023187902 scopus 로고
    • Phosphate repression of cephamycin and clavulanic acid production by Streptomyces clavuligerus
    • Lebrihi, A., P. Germain, and G. Lefebvre. 1987. Phosphate repression of cephamycin and clavulanic acid production by Streptomyces clavuligerus. Appl. Microbiol. Biotechnol. 26: 130-135.
    • (1987) Appl. Microbiol. Biotechnol. , vol.26 , pp. 130-135
    • Lebrihi, A.1    Germain, P.2    Lefebvre, G.3
  • 11
    • 0023901371 scopus 로고
    • Carbon catabolite regulation of cephamycin C and expandase biosynthesis in Streptomyces clavuligerus
    • Lebrihi, A., G. Lefebvre, and P. Germain. 1988. Carbon catabolite regulation of cephamycin C and expandase biosynthesis in Streptomyces clavuligerus. Appl. Microbiol. Biotechnol. 28: 44-51.
    • (1988) Appl. Microbiol. Biotechnol. , vol.28 , pp. 44-51
    • Lebrihi, A.1    Lefebvre, G.2    Germain, P.3
  • 12
    • 2442632286 scopus 로고
    • Repression and inhibition of cephalosporin synthetases in Streptomyces clavuligerus by inorganic phosphate
    • Lübbe, C., S. Wolfe, and A. L. Demain. 1985. Repression and inhibition of cephalosporin synthetases in Streptomyces clavuligerus by inorganic phosphate. Arch. Microbiol. 115: 169-173.
    • (1985) Arch. Microbiol. , vol.115 , pp. 169-173
    • Lübbe, C.1    Wolfe, S.2    Demain, A.L.3
  • 13
    • 0024486867 scopus 로고
    • Lysine catabolism in Streptomyces spp. is primarly through cadaverine: β-lactam producers also make α-aminoadipate
    • Madduri, K., C. Stuttard, and L. C. Vining. 1989. Lysine catabolism in Streptomyces spp. is primarly through cadaverine: β-lactam producers also make α-aminoadipate. J. Bacteriol. 171: 299-302.
    • (1989) J. Bacteriol. , vol.171 , pp. 299-302
    • Madduri, K.1    Stuttard, C.2    Vining, L.C.3
  • 14
    • 0026021342 scopus 로고
    • Cloning and location of a gene governing lysine P-aminotransterase, an enzyme initiating β-lactam biosynthesis in Streptomyces spp
    • Madduri, K., C. Stuttard, and L. C. Vining. 1991. Cloning and location of a gene governing lysine P-aminotransterase, an enzyme initiating β-lactam biosynthesis in Streptomyces spp. J. Bacteriol. 173: 985-988.
    • (1991) J. Bacteriol. , vol.173 , pp. 985-988
    • Madduri, K.1    Stuttard, C.2    Vining, L.C.3
  • 16
    • 0023610542 scopus 로고
    • In vivo conversion of penicillin N to a cephalosporin type antibiotic by a non-producing mutant of Streptomyces clavuligerus
    • Mahro, B. and A. Demain. 1987. In vivo conversion of penicillin N to a cephalosporin type antibiotic by a non-producing mutant of Streptomyces clavuligerus. Appl. Microbiol. Biotechnol. 27: 272-275.
    • (1987) Appl. Microbiol. Biotechnol. , vol.27 , pp. 272-275
    • Mahro, B.1    Demain, A.2
  • 17
    • 0026244999 scopus 로고
    • Kinetic analysis of cephalosporin biosynthesis in Streptomyces clavuligerus
    • Malmberg, L.-H. and W.-S. Hu. 1991. Kinetic analysis of cephalosporin biosynthesis in Streptomyces clavuligerus. Biotechnol. Bioeng. 38: 941-947.
    • (1991) Biotechnol. Bioeng. , vol.38 , pp. 941-947
    • Malmberg, L.-H.1    Hu, W.-S.2
  • 18
    • 0027439293 scopus 로고
    • Precursor flux control through targeted chromosomal insertion of the lysine ∈-aminotransferase (lat) gene in cephamycin C biosynthesis
    • Malmberg, L.-H., W.-S. Hu, and D.H. Sherman. 1993. Precursor flux control through targeted chromosomal insertion of the lysine ∈-aminotransferase (lat) gene in cephamycin C biosynthesis. J. Bacteriol. 175: 6916-6924.
    • (1993) J. Bacteriol. , vol.175 , pp. 6916-6924
    • Malmberg, L.-H.1    Hu, W.-S.2    Sherman, D.H.3
  • 19
    • 0026644055 scopus 로고
    • Analysis of rate-limiting reactions in cephalosporin biosynthesis
    • Malmberg, L.-H., D. H. Sherman, and W.-S. Hu. 1992. Analysis of rate-limiting reactions in cephalosporin biosynthesis. Ann. N.Y. Acad. Sci. 665: 6-26.
    • (1992) Ann. N.Y. Acad. Sci. , vol.665 , pp. 6-26
    • Malmberg, L.-H.1    Sherman, D.H.2    Hu, W.-S.3
  • 20
    • 0028886488 scopus 로고
    • Effects of enhanced lysine ∈-aminotransferase activity on cephamycin biosynthesis in Streptomyces clavuligerus
    • Malmberg, L.-H., W.-S. Hu, and D. H. Sherman. 1995. Effects of enhanced lysine ∈-aminotransferase activity on cephamycin biosynthesis in Streptomyces clavuligerus. Appl. Microbiol. Biotechnol. 44: 198-205.
    • (1995) Appl. Microbiol. Biotechnol. , vol.44 , pp. 198-205
    • Malmberg, L.-H.1    Hu, W.-S.2    Sherman, D.H.3
  • 21
    • 0020062322 scopus 로고
    • Regulation of cephamycin C synthesis, aspartokinase, dihydrodipicolinic acid synthetase and homoserine dehydrogenase by aspartic acid family amino acids in Streptomyces clavuligerus
    • Mendelovitz, S. and Y. Aharonowitz. 1982. Regulation of cephamycin C synthesis, aspartokinase, dihydrodipicolinic acid synthetase and homoserine dehydrogenase by aspartic acid family amino acids in Streptomyces clavuligerus. Antimicrob. Agents Chemother. 21: 78-84.
    • (1982) Antimicrob. Agents Chemother. , vol.21 , pp. 78-84
    • Mendelovitz, S.1    Aharonowitz, Y.2
  • 22
    • 84978697260 scopus 로고
    • Transcriptional regulation of the genes involved in the early steps of the cephamycin biosynthetic pathway in Streptomyces clavuligerus
    • Abstr. S4.3, Montreal
    • Petrich, A. K. and S. E. Jensen. 1994. Transcriptional regulation of the genes involved in the early steps of the cephamycin biosynthetic pathway in Streptomyces clavuligerus. p. 63. Abstr. S4.3, Proc. 7th Internat. Symp. Genet. Industr. Microorgs., Montreal.
    • (1994) Proc. 7th Internat. Symp. Genet. Industr. Microorgs. , pp. 63
    • Petrich, A.K.1    Jensen, S.E.2
  • 23
    • 0028224034 scopus 로고
    • Transcriptional mapping of the genes encoding the early enzymes of the cephamycin biosynthetic pathway of Streptomyces clavuligerus
    • Petrich, A. K., B. K. Leskiw, A. S. Paradkar, and S. E. Jensen. 1994. Transcriptional mapping of the genes encoding the early enzymes of the cephamycin biosynthetic pathway of Streptomyces clavuligerus. Gene 142: 41-48.
    • (1994) Gene 142 , pp. 41-48
    • Petrich, A.K.1    Leskiw, B.K.2    Paradkar, A.S.3    Jensen, S.E.4
  • 24
    • 0026593978 scopus 로고
    • Transcriptional analysis of the isopenicillin N synthase-encoding gene for Streptomyces clavuligerus
    • Petrich, A. K., X. Wu, K. L. Roy, and S. E. Jensen. 1992. Transcriptional analysis of the isopenicillin N synthase-encoding gene for Streptomyces clavuligerus. Gene 111: 77-84.
    • (1992) Gene 111 , pp. 77-84
    • Petrich, A.K.1    Wu, X.2    Roy, K.L.3    Jensen, S.E.4
  • 27
    • 0030296996 scopus 로고    scopus 로고
    • Induction of L-lysine ∈-aminotransferase by L-lysine in Streptomyces clavuligerus, producer of cephalosporins
    • in press
    • Rius, N., K. Maeda, and A. L. Demain. 1996. induction of L-lysine ∈-aminotransferase by L-lysine in Streptomyces clavuligerus, producer of cephalosporins. FEMS Microbiol. Lett, in press.
    • (1996) FEMS Microbiol. Lett
    • Rius, N.1    Maeda, K.2    Demain, A.L.3
  • 28
    • 0021685685 scopus 로고
    • Dissociation of cephamycin and clavulanic acid biosynthesis in Streptomyces clavuligerus
    • Romero, J., P. Liras, and J. F. Martin. 1984. Dissociation of cephamycin and clavulanic acid biosynthesis in Streptomyces clavuligerus. Appl. Microbiol. Biotechnol. 20: 318-325.
    • (1984) Appl. Microbiol. Biotechnol. , vol.20 , pp. 318-325
    • Romero, J.1    Liras, P.2    Martin, J.F.3
  • 29
    • 0023841392 scopus 로고
    • Isolation and biochemical characterization of Streptomyces clavuligerus mutants in the biosynthesis of clavulanic acid and cephamycin C
    • Romero, J. M., P. Liras, and J. F. Martin. 1988. Isolation and biochemical characterization of Streptomyces clavuligerus mutants in the biosynthesis of clavulanic acid and cephamycin C. Appl. Microbiol. Biotechnol. 28: 510-516.
    • (1988) Appl. Microbiol. Biotechnol. , vol.28 , pp. 510-516
    • Romero, J.M.1    Liras, P.2    Martin, J.F.3
  • 30
    • 2442577806 scopus 로고    scopus 로고
    • Partial purification, characterization and nitrogen regulation of the lysine ∈-aminotransferase of Streptomyces clavuligerus
    • in press
    • Romero, J. M., J. F. Martin, P. Liras, A. L. Demain, and N. Rius. 1996. Partial purification, characterization and nitrogen regulation of the lysine ∈-aminotransferase of Streptomyces clavuligerus. J. Industr. Microbiol. in press.
    • (1996) J. Industr. Microbiol.
    • Romero, J.M.1    Martin, J.F.2    Liras, P.3    Demain, A.L.4    Rius, N.5
  • 31
    • 0014349596 scopus 로고
    • L-lysine α-ketoglutarate aminotransferase. 1. Identification of a product. 1-pipendeine-6-carboxylic acid
    • Soda, K., H. Misono, and T. Yamamoto. 1968. L-lysine α-ketoglutarate aminotransferase. 1. Identification of a product. 1-pipendeine-6-carboxylic acid. Biochemistry 7: 4102-4109.
    • (1968) Biochemistry , vol.7 , pp. 4102-4109
    • Soda, K.1    Misono, H.2    Yamamoto, T.3
  • 32
    • 0025925334 scopus 로고
    • Localization of the lysine ∈-aminotransferase (lat) and δ-(L-α-aminoadipyi)-L-cysteinyl-D-valine synthetase (pcbAB) genes from Streptomyces clavuligerus and production of lysine ∈-aminotransferase activity in Escherichia coll
    • Tobin, M. B., S. Kovacevic, K. Madduri, J. A. Hoskins, P. L. Skatrud, L. C. Vining, C. Stuttard, and J. R. Miller. 1991. Localization of the lysine ∈-aminotransferase (lat) and δ-(L-α-aminoadipyi)-L-cysteinyl-D-valine synthetase (pcbAB) genes from Streptomyces clavuligerus and production of lysine ∈-aminotransferase activity in Escherichia coll J. Bacteriol. 173: 6223-6229.
    • (1991) J. Bacteriol. , vol.173 , pp. 6223-6229
    • Tobin, M.B.1    Kovacevic, S.2    Madduri, K.3    Hoskins, J.A.4    Skatrud, P.L.5    Vining, L.C.6    Stuttard, C.7    Miller, J.R.8
  • 33
    • 0023621496 scopus 로고
    • Cephamycin production and isopenicillin N synthetase activity in cultures of Streptomyces clavuligerus
    • Vining, L. C., S. E. Jensen, D. W. S. Westlake, Y. Aharonowitz, and S. Wolfe. 1987. Cephamycin production and isopenicillin N synthetase activity in cultures of Streptomyces clavuligerus. Appl. Microbiol. Biotechnol. 27: 240-246.
    • (1987) Appl. Microbiol. Biotechnol. , vol.27 , pp. 240-246
    • Vining, L.C.1    Jensen, S.E.2    Westlake, D.W.S.3    Aharonowitz, Y.4    Wolfe, S.5
  • 34
    • 0015312226 scopus 로고
    • Incorpration of labeled precursors into A16886B, a novel β-lactam antibiotic produced by Streptomyces clavuligerus
    • Whitney, J. G., D. R. Brannon, J. A. Mabe, and K. J. Wicker. 1972. Incorpration of labeled precursors into A16886B, a novel β-lactam antibiotic produced by Streptomyces clavuligerus. Antimicrob. Agents Chemother. 1: 247-251.
    • (1972) Antimicrob. Agents Chemother. , vol.1 , pp. 247-251
    • Whitney, J.G.1    Brannon, D.R.2    Mabe, J.A.3    Wicker, K.J.4
  • 35
    • 0028576847 scopus 로고
    • Possible involvement of the lysine ∈-aminotransferase gene (lat) in the expression of the genes encoding ACV synthetase (pcbAB) and isopenicillin N synthetase (pcbC) in Streptomyces clavuligerus
    • Yu, H., E. Serpe, J. Romero, J.-J. Coque, K. Maeda, M. Oelgeschl ger, G. Hintermann, P. Liras, J.-F. Martín, A. L. Demain, and J. Piret. 1994. Possible involvement of the lysine ∈-aminotransferase gene (lat) in the expression of the genes encoding ACV synthetase (pcbAB) and isopenicillin N synthetase (pcbC) in Streptomyces clavuligerus. Microbiology 140: 3367-3377.
    • (1994) Microbiology , vol.140 , pp. 3367-3377
    • Yu, H.1    Serpe, E.2    Romero, J.3    Coque, J.-J.4    Maeda, K.5    Oelgeschl Ger, M.6    Hintermann, G.7    Liras, P.8    Martín, J.-F.9    Demain, A.L.10    Piret, J.11
  • 36
    • 0026768872 scopus 로고
    • Regulation of ACV synthetase activity in the beta-lactam biosynthetic pathway by carbon sources and their metabolites
    • Zhang, J. and A. L. Demain. 1992. Regulation of ACV synthetase activity in the beta-lactam biosynthetic pathway by carbon sources and their metabolites. Arch. Microbiol. 158: 364-369.
    • (1992) Arch. Microbiol. , vol.158 , pp. 364-369
    • Zhang, J.1    Demain, A.L.2
  • 37
    • 0024603955 scopus 로고
    • Ammonium ions repress δ-(L-α-aminoadipyl)-L-cysteinyl-D-valine synthetase in Streptomyces clavuligerus NRRL 3585
    • Zhang, J.-Y., S. Wolfe, and A. L. Demain. 1989. Ammonium ions repress δ-(L-α-aminoadipyl)-L-cysteinyl-D-valine synthetase in Streptomyces clavuligerus NRRL 3585. Can. J. Microbiol. 35: 399-402.
    • (1989) Can. J. Microbiol. , vol.35 , pp. 399-402
    • Zhang, J.-Y.1    Wolfe, S.2    Demain, A.L.3
  • 38
    • 0024489265 scopus 로고
    • Phosphate regulation of ACV synthetase and cephalosporin biosynthesis in Streptomyces clavuligerus
    • Zhang, J.-Y., S. Wolfe, and A. L. Demain. 1989. Phosphate regulation of ACV synthetase and cephalosporin biosynthesis in Streptomyces clavuligerus. FEMS Microbiol. Lett. 57: 145-150.
    • (1989) FEMS Microbiol. Lett. , vol.57 , pp. 145-150
    • Zhang, J.-Y.1    Wolfe, S.2    Demain, A.L.3


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