Asymmetric addition reactions of Grignard reagents to chiral fluoral hemiacetal: Asymmetric synthesis of 1-substituted-2,2,2-trifluoroethylamines

Synlett

Volumn , Issue 12, 1997, Pages 1381-1382

  Ishii, Akihiro ^a,c   Higashiyama, Kimio ^b   Mikami, Koichi ^a  

^a TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^b HOSHI UNIVERSITY   (Japan)

^c CENTRAL GLASS CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0000646412     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-1997-1078     Document Type: Article

References (27)

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13. Previous reports on the preparation of chiral 1-substituted-2,2,2-trifluoroethylamines: (a) Asymmetric reduction of chiral imine: Pirkle, W. H.; Hauske, J. R. J. Org. Chem. 1977, 42, 2436.
14. (b) Optical resolution: Wang, Y.; Mosher, H. S. Tetrahedron Lett. 1991, 32, 987.
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16. +) m/z 217.0714, found 217.0711.
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20. (b) Also see: ref. 4 (a).
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24. -1.
25. 4, was used in the following reactions.
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27. 4: Takahashi, H.; Hsieh, B. C.; Higashiyama, K. Chem. Pharm. Bull. 1990, 38, 2429.