Synthesis of constrained bicyclic dipeptide mimetics

Tetrahedron Letters

Volumn 38, Issue 51, 1997, Pages 8807-8810

  Siddiqui, M Arshad ^a   Préville, Patrice ^a   Tarazi, Micheline ^a   Warder, Scott E ^a   Eby, Paul ^a   Gorseth, Elise ^a   Puumala, Karen ^a   DiMaio, John ^a  

^a Shire BioChem Inc   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DIPEPTIDE; PSEUDOPEPTIDE; THROMBIN INHIBITOR;

ARTICLE; CHIRALITY; DRUG SYNTHESIS; IN VITRO STUDY; INFRARED SPECTROPHOTOMETRY; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; REACTION ANALYSIS; STEREOCHEMISTRY;

EID: 0000630048     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(97)10422-1     Document Type: Article

References (21)

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16. 3) δ 1.28-1.31 (m, 3H), 1.72-1.81 (m, 3H), 2.11-2.13 (m, 1H), 2. 66 (dd, 1H, J= 13.6 and 11 Hz), 2.74-2.76 (m, 1H), 3.14 (dd, 1H, J= 11.5 and 6 Hz), 3.29-3.34 (m, 2H), 4.19-4.29 (m, 2H), 4.88 (dd, 1H, J= 8.8 and 4.6 Hz), 5.22 (dd, 1H, J= 8 and 6 Hz), 7.18-7.23 (m, 3H), 7.26-7.31( m, 2H).
17. Coordinates of mimetics 1 and 2 will be deposited at the Cambridge crystallographic data bank.
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19. 3).
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