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Volumn 1, Issue 6, 1998, Pages 307-314

Receptor affinity and potency of non-steroidal antiandrogens: Translation of preclinical findings into clinical activity

Author keywords

Antiandrogen; Bicalutamide; Flutamide; Nilutamide; Prostate cancer

Indexed keywords


EID: 0000428935     PISSN: 13657852     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.pcan.4500262     Document Type: Article
Times cited : (43)

References (80)
  • 1
    • 84928580276 scopus 로고
    • Studies on prostatic cancer. 1. The effect of castration of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate
    • Huggins C, Hodges CV. Studies on prostatic cancer. 1. The effect of castration of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate. Cancer Res 1941; 1: 293-297.
    • (1941) Cancer Res , vol.1 , pp. 293-297
    • Huggins, C.1    Hodges, C.V.2
  • 2
    • 0029119521 scopus 로고
    • Advances and trends in hormonal therapy for advanced prostate cancer
    • Debruyne FMJ, Dijkman GA. Advances and trends in hormonal therapy for advanced prostate cancer. Eur Urol 1995; 28: 177-188.
    • (1995) Eur Urol , vol.28 , pp. 177-188
    • Debruyne, F.M.J.1    Dijkman, G.A.2
  • 3
    • 0029963602 scopus 로고    scopus 로고
    • Recent advances in the medical management of prostate cancer
    • Kirby RS. Recent advances in the medical management of prostate cancer. Crit J Clin Pract 1996; 50: 88-93.
    • (1996) Crit J Clin Pract , vol.50 , pp. 88-93
    • Kirby, R.S.1
  • 4
    • 0014088849 scopus 로고
    • Treatment and survival of patients with cancer of the prostate
    • Veterans Administration Cooperative Urological Group. Treatment and survival of patients with cancer of the prostate. Surg Gynecol Obstet 1967; 124: 1011-1017.
    • (1967) Surg Gynecol Obstet , vol.124 , pp. 1011-1017
  • 5
    • 0025828605 scopus 로고
    • Comparison of LHRH analogue (Zoladex) with orchiectomy in patients with metastatic prostatic cancer
    • Kaisary AV et al. Comparison of LHRH analogue (Zoladex) with orchiectomy in patients with metastatic prostatic cancer. Br J Urol 1991; 67: 502-508.
    • (1991) Br J Urol , vol.67 , pp. 502-508
    • Kaisary, A.V.1
  • 6
    • 0024208596 scopus 로고
    • The combination of cyproterone acetate and low dose diethylstilbestrol in the treatment of advanced prostate carcinoma
    • Goldenberg SL, Bruchowsky N, Rennie PS, Coppin CM. The combination of cyproterone acetate and low dose diethylstilbestrol in the treatment of advanced prostate carcinoma. J Urol 1988; 140: 1460-1465.
    • (1988) J Urol , vol.140 , pp. 1460-1465
    • Goldenberg, S.L.1    Bruchowsky, N.2    Rennie, P.S.3    Coppin, C.M.4
  • 7
    • 3142554300 scopus 로고    scopus 로고
    • The role of adrenal androgens in prostate cancer
    • Pasqualini JR, Katzenellenbogen BS (eds). Marcel Dekker: New York
    • Geller J. The role of adrenal androgens in prostate cancer. In: Pasqualini JR, Katzenellenbogen BS (eds). Hormone-Dependent Cancer. Marcel Dekker: New York, 1996, 289-305.
    • (1996) Hormone-Dependent Cancer , pp. 289-305
    • Geller, J.1
  • 8
    • 0001837770 scopus 로고
    • Role of cyproterone acetate in urology. Martini L, Motta M (eds). Raven Press: New York
    • Bracci U, Di Silverio F. In: Role of cyproterone acetate in urology. Martini L, Motta M (eds). Androgens and Antiandrogens. Raven Press: New York, 1977, 333-339.
    • (1977) Androgens and Antiandrogens , pp. 333-339
    • Bracci, U.1    Di Silverio, F.2
  • 9
    • 0020354138 scopus 로고
    • New hormonal therapy in prostate carcinoma: Combined treatment with an LHRH agonist and an antiandrogen
    • Labrie F et al. New hormonal therapy in prostate carcinoma: combined treatment with an LHRH agonist and an antiandrogen. Clin Invest Med 1982; 5: 267-275.
    • (1982) Clin Invest Med , vol.5 , pp. 267-275
    • Labrie, F.1
  • 10
    • 0031049759 scopus 로고    scopus 로고
    • Antiandrogen monotherapy in the management of advanced prostate cancer
    • Kaisary AV. Antiandrogen monotherapy in the management of advanced prostate cancer. J Urol 1997; 31 (Suppl 2): 14-19.
    • (1997) J Urol , vol.31 , Issue.2 SUPPL. , pp. 14-19
    • Kaisary, A.V.1
  • 11
    • 0028466225 scopus 로고
    • Cyproterone: A review of its pharmacology and therapeutic efficacy in prostate cancer
    • Barradell LB, Faulds D. Cyproterone: a review of its pharmacology and therapeutic efficacy in prostate cancer. Drugs Aging 1994; 5: 59-80.
    • (1994) Drugs Aging , vol.5 , pp. 59-80
    • Barradell, L.B.1    Faulds, D.2
  • 12
    • 0026646685 scopus 로고
    • Hepatitis due to cyproterone acetate
    • Drakos PE, Gez E, Catane R. Hepatitis due to cyproterone acetate. Eur J Cancer 1992; 28A: 1932-1933.
    • (1992) Eur J Cancer , vol.28 A , pp. 1932-1933
    • Drakos, P.E.1    Gez, E.2    Catane, R.3
  • 13
    • 0028046286 scopus 로고
    • Liver tumours in women on oral contraceptives
    • Rabe T, Feldmann K, Grunwald K, Runnebaum B. Liver tumours in women on oral contraceptives. Lancet 1994; 334: 1568-1569.
    • (1994) Lancet , vol.334 , pp. 1568-1569
    • Rabe, T.1    Feldmann, K.2    Grunwald, K.3    Runnebaum, B.4
  • 14
    • 0014131074 scopus 로고
    • Biological studies on an antiandrogen (SH 714)
    • Neri RO et al. Biological studies on an antiandrogen (SH 714). Eur J Pharmacol 1967; 1: 438-444.
    • (1967) Eur J Pharmacol , vol.1 , pp. 438-444
    • Neri, R.O.1
  • 15
    • 0342864241 scopus 로고
    • Flutamide versus orchidectomy in patients with metastatic prostate cancer
    • Boccon-Gibod L et al. Flutamide versus orchidectomy in patients with metastatic prostate cancer. J Urol 1992; 147: 417A.
    • (1992) J Urol , vol.147
    • Boccon-Gibod, L.1
  • 16
    • 0027182961 scopus 로고
    • Goserelin acetate and flutamide versus bilateral orchidectomy: A phase III EORTC trial (30853)
    • Denis LJ et al. Goserelin acetate and flutamide versus bilateral orchidectomy: a phase III EORTC trial (30853). Urology 1993; 42: 119-130.
    • (1993) Urology , vol.42 , pp. 119-130
    • Denis, L.J.1
  • 17
    • 0026115791 scopus 로고
    • Flutamide- A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in advanced prostatic cancer
    • Brogden RN, Chrisp P. Flutamide- a review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in advanced prostatic cancer. Drugs Aging 1991; 1: 104-115.
    • (1991) Drugs Aging , vol.1 , pp. 104-115
    • Brogden, R.N.1    Chrisp, P.2
  • 18
    • 0029656166 scopus 로고    scopus 로고
    • Flutamide hepatotoxicity
    • Wysowski DK, Fourcroy JL. Flutamide hepatotoxicity. J Urol 1996; 155: 209-212.
    • (1996) J Urol , vol.155 , pp. 209-212
    • Wysowski, D.K.1    Fourcroy, J.L.2
  • 19
    • 0027457020 scopus 로고
    • Orchiectomy and nilutamide or placebo as treatment of metastatic prostatic cancer in a multinational double-blind randomized trial
    • Janknegt RA et al. Orchiectomy and nilutamide or placebo as treatment of metastatic prostatic cancer in a multinational double-blind randomized trial. J Urol 1993; 149: 77-83.
    • (1993) J Urol , vol.149 , pp. 77-83
    • Janknegt, R.A.1
  • 20
    • 0023180623 scopus 로고
    • ICI 176,334: A novel non-steroidal, peripherally selective antiandrogen
    • Furr BJA et al. ICI 176,334: a novel non-steroidal, peripherally selective antiandrogen. J Endocrinol 1987; 113: R7-R9.
    • (1987) J Endocrinol , vol.113
    • Furr, B.J.A.1
  • 21
    • 0028290668 scopus 로고
    • Current clinical studies with a new non-steroidal antiandrogen, Casodex
    • Kaisary AV. Current clinical studies with a new non-steroidal antiandrogen, Casodex. Prostate 1994; 5: 27-33.
    • (1994) Prostate , vol.5 , pp. 27-33
    • Kaisary, A.V.1
  • 22
    • 0029560859 scopus 로고    scopus 로고
    • Pharmacodynamics and pharmacokinetics of bicalutamide: Defining an active dosing regimen
    • Denis L, Mahler C. Pharmacodynamics and pharmacokinetics of bicalutamide: defining an active dosing regimen. Urology 1996; 47: 26-28.
    • (1996) Urology , vol.47 , pp. 26-28
    • Denis, L.1    Mahler, C.2
  • 23
    • 0029561444 scopus 로고    scopus 로고
    • The preclinical development of bicalutamide: Pharmacodynamics and mechanism of action
    • Furr BJA, Tucker H. The preclinical development of bicalutamide: pharmacodynamics and mechanism of action. Urology 1996; 47 (Suppl 1A): 13-25.
    • (1996) Urology , vol.47 , Issue.SUPPL. 1A , pp. 13-25
    • Furr, B.J.A.1    Tucker, H.2
  • 24
    • 0029618361 scopus 로고    scopus 로고
    • Worldwide activity and safety of bicalutamide: A summary review
    • Kolvenbag GJCM, Blacklcdge GRP. Worldwide activity and safety of bicalutamide: a summary review. Urology 1996; 47: 70-79.
    • (1996) Urology , vol.47 , pp. 70-79
    • Kolvenbag, G.J.C.M.1    Blacklcdge, G.R.P.2
  • 25
    • 0030876587 scopus 로고    scopus 로고
    • Bicalutamide (Casodex) development: From theory to therapy
    • Kolvenbag GJCM, Furr BJA. Bicalutamide (Casodex) development: from theory to therapy. Cancer J 1997; 3: 192-203.
    • (1997) Cancer J , vol.3 , pp. 192-203
    • Kolvenbag, G.J.C.M.1    Furr, B.J.A.2
  • 26
    • 0031594361 scopus 로고    scopus 로고
    • Bicalutamide (Casodex) in the treatment of prostate cancer: History of clinical development
    • Kolvenbag GJCM, Blackledge GRP, Gotting Smith K. Bicalutamide (Casodex) in the treatment of prostate cancer: history of clinical development. Prostate 1998; 34: 61-72.
    • (1998) Prostate , vol.34 , pp. 61-72
    • Kolvenbag, G.J.C.M.1    Blackledge, G.R.P.2    Gotting Smith, K.3
  • 27
    • 0028256464 scopus 로고
    • Non-steroidal antiandrogens: Synthesis and biological profile of high-affinity ligands for the androgen receptor
    • Teutsch G et al. Non-steroidal antiandrogens: synthesis and biological profile of high-affinity ligands for the androgen receptor. J Steroid Biochem 1994; 48: 111-119.
    • (1994) J Steroid Biochem , vol.48 , pp. 111-119
    • Teutsch, G.1
  • 28
    • 0024810584 scopus 로고
    • Studies on the mechanism of action of WIN49596: A steroidal androgen receptor antagonist
    • Winneker RC, Wagner MM, Batzold FH. Studies on the mechanism of action of WIN49596: a steroidal androgen receptor antagonist. J Steroid Biochem 1989; 33: 1133-1138.
    • (1989) J Steroid Biochem , vol.33 , pp. 1133-1138
    • Winneker, R.C.1    Wagner, M.M.2    Batzold, F.H.3
  • 29
    • 0024434433 scopus 로고
    • 3H]-cortisol binding to plasma proteins
    • 3H]-cortisol binding to plasma proteins. J Steroid Biochem 1989; 33: 251-255.
    • (1989) J Steroid Biochem , vol.33 , pp. 251-255
    • Ayub, M.1    Levell, M.J.2
  • 30
    • 0030200951 scopus 로고    scopus 로고
    • Agonist and antagonist activities of hydroxyflutamide and Casodex relate to androgen receptor stabilization
    • Kemppainen JA, Wilson EM. Agonist and antagonist activities of hydroxyflutamide and Casodex relate to androgen receptor stabilization. Urology 1996; 48: 157-163.
    • (1996) Urology , vol.48 , pp. 157-163
    • Kemppainen, J.A.1    Wilson, E.M.2
  • 31
    • 0029910874 scopus 로고    scopus 로고
    • Relative potencies of flutamide and Casodex preclinical studies
    • Luo S et al. Relative potencies of flutamide and Casodex preclinical studies. Eudocr Relat Cancer 1996; 3: 229-241.
    • (1996) Eudocr Relat Cancer , vol.3 , pp. 229-241
    • Luo, S.1
  • 32
    • 0030854929 scopus 로고    scopus 로고
    • Relative potencies of flutamide and Casodex
    • Furr BJA. Relative potencies of flutamide and Casodex. Endocr Relat Cancer 1997; 4: 197-202.
    • (1997) Endocr Relat Cancer , vol.4 , pp. 197-202
    • Furr, B.J.A.1
  • 33
    • 0029863106 scopus 로고    scopus 로고
    • Enantioselective binding of Casodex to the androgen receptor
    • Mukherjee A et al. Enantioselective binding of Casodex to the androgen receptor. Xenobiotica 1996; 26: 117-122.
    • (1996) Xenobiotica , vol.26 , pp. 117-122
    • Mukherjee, A.1
  • 34
    • 0026081441 scopus 로고
    • Evaluation of a peripherally selective antiandrogen (Casodex) as a tool for studying the relationship between testosterone and spermatogenesis in the rat
    • Chandolia RK, Weinbauer GF, Behre HM, Nieschlag E. Evaluation of a peripherally selective antiandrogen (Casodex) as a tool for studying the relationship between testosterone and spermatogenesis in the rat. J Steroid Biochem Mol Biol 1991; 18: 367-375.
    • (1991) J Steroid Biochem Mol Biol , vol.18 , pp. 367-375
    • Chandolia, R.K.1    Weinbauer, G.F.2    Behre, H.M.3    Nieschlag, E.4
  • 35
    • 0026356506 scopus 로고
    • Comparative effects of chronic administration of the non-steroidal antiandrogens flutamide and Casodex on the reproductive system of the male rat
    • Chandolia RK, Weinbauer GF, Simoni M, Behre HM, Nieschlag E. Comparative effects of chronic administration of the non-steroidal antiandrogens flutamide and Casodex on the reproductive system of the male rat. Acta Endocrinologica 1991; 125: 547-555.
    • (1991) Acta Endocrinologica , vol.125 , pp. 547-555
    • Chandolia, R.K.1    Weinbauer, G.F.2    Simoni, M.3    Behre, H.M.4    Nieschlag, E.5
  • 36
    • 0027535548 scopus 로고
    • Effects of antiandrogens and ethane dimethane sulphonate (EDS) on gene expression, free subunits, bioactivity and secretion of pituitary gonadotrophins in male rats
    • Gromoll J, Weinbauer GF, Simoni M, Nieschlag E. Effects of antiandrogens and ethane dimethane sulphonate (EDS) on gene expression, free subunits, bioactivity and secretion of pituitary gonadotrophins in male rats. Mol Cell Eudocrinol 1993; 91: 119-125.
    • (1993) Mol Cell Eudocrinol , vol.91 , pp. 119-125
    • Gromoll, J.1    Weinbauer, G.F.2    Simoni, M.3    Nieschlag, E.4
  • 37
    • 0032510051 scopus 로고    scopus 로고
    • Synthesis and biological activity of a novel series of nonsteroidal, peripherally selective androgen receptor antagonists derived from 1,2-Dihydropyridono[5,6-g]quinolines
    • Hamann LG et al. Synthesis and biological activity of a novel series of nonsteroidal, peripherally selective androgen receptor antagonists derived from 1,2-Dihydropyridono[5,6-g]quinolines. J Med Chem 1998; 41: 623-639.
    • (1998) J Med Chem , vol.41 , pp. 623-639
    • Hamann, L.G.1
  • 38
    • 0025303453 scopus 로고
    • The effect of the steroidal androgen receptor antagonist, Win 49,596, on the prostate and testis of beagle dogs
    • Juniewicz PE et al. The effect of the steroidal androgen receptor antagonist, Win 49,596, on the prostate and testis of beagle dogs. Endocrinology 1990; 126: 2625-2634.
    • (1990) Endocrinology , vol.126 , pp. 2625-2634
    • Juniewicz, P.E.1
  • 39
    • 0015395231 scopus 로고
    • Effects of a novel, non-steroidal anti-androgen on canine prostate hyperplasia
    • Neri RO, Monahan M. Effects of a novel, non-steroidal anti-androgen on canine prostate hyperplasia. Invest Urol 1972; 10: 123-130.
    • (1972) Invest Urol , vol.10 , pp. 123-130
    • Neri, R.O.1    Monahan, M.2
  • 40
    • 0015377166 scopus 로고
    • A biological profile of a non-steroidal antiandrogen, SCH 13521 (4′-nitro-3′-trifluoromethyllisobutyranilide)
    • Neri R, Florence K, Koziol P, von Cleave S. A biological profile of a non-steroidal antiandrogen, SCH 13521 (4′-nitro-3′-trifluoromethyllisobutyranilide). Endocrinology 1972; 91: 427-437.
    • (1972) Endocrinology , vol.91 , pp. 427-437
    • Neri, R.1    Florence, K.2    Koziol, P.3    Von Cleave, S.4
  • 41
    • 0025281218 scopus 로고
    • Effect of a non-steroidal antiandrogen, anandron, on the reproductive system and fertility in male rats
    • Dhar JD, Setty BS. Effect of a non-steroidal antiandrogen, anandron, on the reproductive system and fertility in male rats. Contraception 1990; 42: 121-138.
    • (1990) Contraception , vol.42 , pp. 121-138
    • Dhar, J.D.1    Setty, B.S.2
  • 42
    • 0026536170 scopus 로고
    • Dunning R3327-G prostate carcinoma of the rat: An appropriate model for drug evaluation
    • Kager M, Spruß T, Schneider MR, von Angerer E. Dunning R3327-G prostate carcinoma of the rat: an appropriate model for drug evaluation. J Cancer Res Clin Oncol 1992; 118: 334-338.
    • (1992) J Cancer Res Clin Oncol , vol.118 , pp. 334-338
    • Kager, M.1    Spruß, T.2    Schneider, M.R.3    Von Angerer, E.4
  • 43
    • 0025644325 scopus 로고
    • A mutation in the ligand binding domain of the androgen receptor of human LNCaP cells affects steroid binding characteristics and response to antiandrogens
    • Veldscholte J et al. A mutation in the ligand binding domain of the androgen receptor of human LNCaP cells affects steroid binding characteristics and response to antiandrogens. Biochem Biophys Res Commun 1990; 173: 534-540.
    • (1990) Biochem Biophys Res Commun , vol.173 , pp. 534-540
    • Veldscholte, J.1
  • 44
    • 0031035330 scopus 로고    scopus 로고
    • Androgen receptor gene mutations in prostate cancer. Implications for disease progression and therapy
    • Culig Z et al. Androgen receptor gene mutations in prostate cancer. Implications for disease progression and therapy. Drugs Aging 1997; 10: 50-58.
    • (1997) Drugs Aging , vol.10 , pp. 50-58
    • Culig, Z.1
  • 45
    • 0030877225 scopus 로고    scopus 로고
    • Functional characterization of mutant androgen receptors from androgen-independent prostate cancer
    • Fenton MA et al. Functional characterization of mutant androgen receptors from androgen-independent prostate cancer. Clin Cancer Res 1997; 3: 1383-1388.
    • (1997) Clin Cancer Res , vol.3 , pp. 1383-1388
    • Fenton, M.A.1
  • 46
    • 0023917872 scopus 로고
    • Characteristics of flutamide action on prostatic and testicular functions in the rat
    • Marchetti B, Labrie F. Characteristics of flutamide action on prostatic and testicular functions in the rat. J Steroid Biochein 1988; 29: 691-698.
    • (1988) J Steroid Biochein , vol.29 , pp. 691-698
    • Marchetti, B.1    Labrie, F.2
  • 47
    • 0027356895 scopus 로고
    • Nilutamide. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in prostatic cancer
    • Harris MG, Coleman SG, Faulds D, Chrisp P. Nilutamide. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in prostatic cancer. Drugs Aging 1993; 3: 9-25.
    • (1993) Drugs Aging , vol.3 , pp. 9-25
    • Harris, M.G.1    Coleman, S.G.2    Faulds, D.3    Chrisp, P.4
  • 48
    • 0024347320 scopus 로고
    • A possible explanation for the peripheral selectivity of a novel non-steroidal pure anti-androgen, Casodex (ICI 176,334)
    • Freeman SN, Mainwaring WIP, Furr BJA. A possible explanation for the peripheral selectivity of a novel non-steroidal pure anti-androgen, Casodex (ICI 176,334). Br J Cancer 1989; 60: 664-668.
    • (1989) Br J Cancer , vol.60 , pp. 664-668
    • Freeman, S.N.1    Mainwaring, W.I.P.2    Furr, B.J.A.3
  • 49
    • 0343674383 scopus 로고
    • Endocrine effects of 'Casodex'. A new non-steroidal antiandrogen
    • Murphy G, Khoury S (eds). American Cancer Society: Atlanta, GA
    • Mahler C et al. Endocrine effects of 'Casodex'. A new non-steroidal antiandrogen. In: Murphy G, Khoury S (eds). Recent Advances in Urological Cancers. American Cancer Society: Atlanta, GA, 1990, 42-45.
    • (1990) Recent Advances in Urological Cancers , pp. 42-45
    • Mahler, C.1
  • 50
    • 0030891612 scopus 로고    scopus 로고
    • Tolerability of non-steroidal antiandrogens in the treatment of advanced prostate cancer
    • McLeod DC. Tolerability of non-steroidal antiandrogens in the treatment of advanced prostate cancer. Oncologist 1997; 2: 18-27.
    • (1997) Oncologist , vol.2 , pp. 18-27
    • McLeod, D.C.1
  • 51
    • 0030824059 scopus 로고    scopus 로고
    • Clinical benefits of bicalutamide (Casodex) versus flutamide (Eulexin) in combined androgen blockade for patients with advanced prostatic carcinoma: Final report of a double-blind, randomized, multicenter trial
    • Schellhammer P et al. Clinical benefits of bicalutamide (Casodex) versus flutamide (Eulexin) in combined androgen blockade for patients with advanced prostatic carcinoma: final report of a double-blind, randomized, multicenter trial. Urology 1997; 50: 330-336.
    • (1997) Urology , vol.50 , pp. 330-336
    • Schellhammer, P.1
  • 52
    • 0025602805 scopus 로고
    • The pharmacokinetics of Casodex in prostatic cancer patients after single and during multiple dosing
    • Cockshott ID et al. The pharmacokinetics of Casodex in prostatic cancer patients after single and during multiple dosing. Eur Urol 1990; 18: 10-17.
    • (1990) Eur Urol , vol.18 , pp. 10-17
    • Cockshott, I.D.1
  • 53
    • 0027364965 scopus 로고
    • Metabolism and enantioselective pharmacokinetics of Casodex in man
    • McKillop D et al. Metabolism and enantioselective pharmacokinetics of Casodex in man. Xenobiotica 1993; 23: 1241-1253.
    • (1993) Xenobiotica , vol.23 , pp. 1241-1253
    • McKillop, D.1
  • 54
    • 9344269894 scopus 로고    scopus 로고
    • A dose-response study of the effect of flutamide on benign prostatic hyperplasia: Results of a multicenter study
    • Narayan P et al. A dose-response study of the effect of flutamide on benign prostatic hyperplasia: results of a multicenter study. Urology 1996; 47: 497-504.
    • (1996) Urology , vol.47 , pp. 497-504
    • Narayan, P.1
  • 55
    • 0030460752 scopus 로고    scopus 로고
    • Recommended dose of flutamide with LH-RH agonist therapy in patients with advanced prostate cancer
    • Akaza H et al. Recommended dose of flutamide with LH-RH agonist therapy in patients with advanced prostate cancer. Int J Urol 1996; 3: 468-471.
    • (1996) Int J Urol , vol.3 , pp. 468-471
    • Akaza, H.1
  • 56
    • 0031036160 scopus 로고    scopus 로고
    • Nilutamide: An antiandrogen for the treatment of prostate cancer
    • Dole EJ, Holdsworth MT. Nilutamide: an antiandrogen for the treatment of prostate cancer. Ann Pharmacother 1997; 31: 65-75.
    • (1997) Ann Pharmacother , vol.31 , pp. 65-75
    • Dole, E.J.1    Holdsworth, M.T.2
  • 57
    • 0021135063 scopus 로고
    • Experience with flutamide in patients with advanced prostatic cancer without prior endocrine therapy
    • Sogani PC, Vagaiwala MR, Whitmore VVF. Experience with flutamide in patients with advanced prostatic cancer without prior endocrine therapy. Cancer 1984; 54: 744-750.
    • (1984) Cancer , vol.54 , pp. 744-750
    • Sogani, P.C.1    Vagaiwala, M.R.2    Whitmore, V.V.F.3
  • 58
    • 0007375137 scopus 로고
    • Experience with flutamide in advanced prostatic patients refractory to previous endocrine therapy
    • Di Sil verio F et al. Experience with flutamide in advanced prostatic patients refractory to previous endocrine therapy. J Drug Dev 1987; 1 (Suppl 1): 10-16.
    • (1987) J Drug Dev , vol.1 , Issue.1 SUPPL. , pp. 10-16
    • Di Sil Verio, F.1
  • 59
    • 0024457325 scopus 로고
    • Antiandrogens alone or in combination for treatment of prostate cancer: The European experience
    • Pavone-Macaluso M et al. Antiandrogens alone or in combination for treatment of prostate cancer: the European experience. Urology 1989; 34 (Suppl 4): 27-36.
    • (1989) Urology , vol.34 , Issue.4 SUPPL. , pp. 27-36
    • Pavone-Macaluso, M.1
  • 60
    • 0024463899 scopus 로고
    • Long-term experience with flutamide in patients with prostatic carcinoma
    • Prout GR et al. Long-term experience with flutamide in patients with prostatic carcinoma. Urology 1989; 34 (Suppl 4): 37-45.
    • (1989) Urology , vol.34 , Issue.4 SUPPL. , pp. 37-45
    • Prout, G.R.1
  • 61
    • 0026338475 scopus 로고
    • Monotherapy with nilutamide, a pure non-steroidal antiandrogen, in untreated patients with metastatic carcinoma of the prostate
    • Dccensi AU et al. Monotherapy with nilutamide, a pure non-steroidal antiandrogen, in untreated patients with metastatic carcinoma of the prostate. J Urol 1991; 146: 377-381.
    • (1991) J Urol , vol.146 , pp. 377-381
    • Dccensi, A.U.1
  • 62
    • 2842523339 scopus 로고
    • Flutamide versus orchidectomy in patients with metastatic prostate carcinoma
    • Abstract 25
    • Boccon-Gibod L et al. Flutamide versus orchidectomy in patients with metastatic prostate carcinoma, 11th Congress of the EAU 1994; Abstract 25.
    • (1994) 11th Congress of the EAU
    • Boccon-Gibod, L.1
  • 63
    • 0029964139 scopus 로고    scopus 로고
    • Clinical progress with a new antiandrogen, Casodex (bicalutamide)
    • Blackledge GRP. Clinical progress with a new antiandrogen, Casodex (bicalutamide). Eur Urol 1996; 29 (Suppl 2): 96-104.
    • (1996) Eur Urol , vol.29 , Issue.2 SUPPL. , pp. 96-104
    • Blackledge, G.R.P.1
  • 64
    • 9444292850 scopus 로고    scopus 로고
    • Double-blind, randomized study of primary hormonal treatment of stage D2 prostate carcinoma: Flutamide versus diethylstilbestrol
    • Chang A et al. Double-blind, randomized study of primary hormonal treatment of stage D2 prostate carcinoma: flutamide versus diethylstilbestrol. J Clin Oncol 1996; 14: 2250-2257.
    • (1996) J Clin Oncol , vol.14 , pp. 2250-2257
    • Chang, A.1
  • 65
    • 0007880760 scopus 로고    scopus 로고
    • A randomised comparison of Casodex 150mg versus castration in the treatment of advanced prostate cancer
    • Abstract 411
    • Tyrrell CJ et al. A randomised comparison of Casodex 150mg versus castration in the treatment of advanced prostate cancer Proceedings of ASCO 15 May 1996, 1996; 15: 192 (Abstract 411).
    • (1996) Proceedings of ASCO 15 May 1996 , vol.15 , pp. 192
    • Tyrrell, C.J.1
  • 66
    • 0032032068 scopus 로고    scopus 로고
    • Casodex (bicalutamide) 150-mg monotherapy compared with castration in patients with previously untreated nonmetastatic prostate cancer: Results from two multicenter randomized trials at a median follow-up of 4 years
    • Iversen P et al. Casodex (bicalutamide) 150-mg monotherapy compared with castration in patients with previously untreated nonmetastatic prostate cancer: results from two multicenter randomized trials at a median follow-up of 4 years. Urology 1998; 51: 389-396.
    • (1998) Urology , vol.51 , pp. 389-396
    • Iversen, P.1
  • 67
    • 0031798627 scopus 로고    scopus 로고
    • A randomised comparison of Casodex (bicalutamide) 150mg monotherapy versus castration in the treatment of metastatic and locally advanced prostate cancer
    • Tyrrell CJ et al. A randomised comparison of Casodex (bicalutamide) 150mg monotherapy versus castration in the treatment of metastatic and locally advanced prostate cancer. Eur Urol 1998; 33: 447-456.
    • (1998) Eur Urol , vol.33 , pp. 447-456
    • Tyrrell, C.J.1
  • 68
    • 0024324367 scopus 로고
    • A controlled trial of leuprolide with and without flutamide in prostatic carcinoma
    • Crawford ED et al. A controlled trial of leuprolide with and without flutamide in prostatic carcinoma. N Engl J Med 1989; 321: 419-424.
    • (1989) N Engl J Med , vol.321 , pp. 419-424
    • Crawford, E.D.1
  • 69
    • 0026317752 scopus 로고
    • A multicentre, randomized trial comparing the luteinising hormone releasing hormone analogue goserelin acetate alone and with flutamide in the treatment of advanced prostate cancer
    • Tyrrell CJ et al. A multicentre, randomized trial comparing the luteinising hormone releasing hormone analogue goserelin acetate alone and with flutamide in the treatment of advanced prostate cancer. J Urol 1991; 146: 1321-1326.
    • (1991) J Urol , vol.146 , pp. 1321-1326
    • Tyrrell, C.J.1
  • 70
    • 0027155356 scopus 로고
    • Goserelin acetate with or without flutamide in the treatment of patients with locally advanced or metastatic prostate cancer
    • Boccardo F et al. Goserelin acetate with or without flutamide in the treatment of patients with locally advanced or metastatic prostate cancer. Eur J Cancer 1993; 29A: 1088-1093.
    • (1993) Eur J Cancer , vol.29 A , pp. 1088-1093
    • Boccardo, F.1
  • 72
    • 0008676139 scopus 로고
    • Zoladex plus flutamide versus Zoladex plus placebo in advanced prostatic carcinoma: Extended follow-up of the French multicentre study
    • Murphy G, Khoury S, Chatelain C, Denis L (eds). SCI
    • Fourcade RO et al. Zoladex plus flutamide versus Zoladex plus placebo in advanced prostatic carcinoma: extended follow-up of the French multicentre study. In: Murphy G, Khoury S, Chatelain C, Denis L (eds). Proceedings of the 3rd International Symposium on Recent Advances in Urological Cancers: Diagnosis and Treatment. SCI 1993, 102-106.
    • (1993) Proceedings of the 3rd International Symposium on Recent Advances in Urological Cancers: Diagnosis and Treatment , pp. 102-106
    • Fourcade, R.O.1
  • 73
    • 0027432563 scopus 로고
    • Long term results of Danish prostatic cancer group trial 86. Goserelin acetate plus flutamide versus orchidectomy in advanced prostatic cancer
    • Iversen P, Rasmussen F, Klarskov J, Christensen IJ. Long term results of Danish prostatic cancer group trial 86. Goserelin acetate plus flutamide versus orchidectomy in advanced prostatic cancer. Cancer 1993; 72 (Suppl 12): 3851-3854.
    • (1993) Cancer , vol.72 , Issue.12 SUPPL. , pp. 3851-3854
    • Iversen, P.1    Rasmussen, F.2    Klarskov, J.3    Christensen, I.J.4
  • 74
    • 0032497522 scopus 로고    scopus 로고
    • Bilateral orchiectomy with or without flutamide for metastatic prostate cancer
    • Eisenberger MA et al. Bilateral orchiectomy with or without flutamide for metastatic prostate cancer. N Engl J Med 1998; 339: 1036-1042.
    • (1998) N Engl J Med , vol.339 , pp. 1036-1042
    • Eisenberger, M.A.1
  • 75
    • 9044231766 scopus 로고    scopus 로고
    • Maximal androgen blockade for patients with metastatic prostate cancer: Outcome of a controlled trial of bicalutamide versus flutamide, each in combination with luteinizing hormone-releasing hormone analogue therapy
    • Schellhammer P et al. Maximal androgen blockade for patients with metastatic prostate cancer: outcome of a controlled trial of bicalutamide versus flutamide, each in combination with luteinizing hormone-releasing hormone analogue therapy. Urology 1996; 47 (Suppl 1A): 54-60.
    • (1996) Urology , vol.47 , Issue.SUPPL. 1A , pp. 54-60
    • Schellhammer, P.1
  • 76
    • 0029803943 scopus 로고    scopus 로고
    • Tolerability and safety of flutamide in monotherapy with orchiectomy or with LHRHa in advanced prostate cancer patients
    • Oosterlinck W et al. Tolerability and safety of flutamide in monotherapy with orchiectomy or with LHRHa in advanced prostate cancer patients. Eur Urol 1996; 30: 458-463.
    • (1996) Eur Urol , vol.30 , pp. 458-463
    • Oosterlinck, W.1
  • 77
    • 0031986409 scopus 로고    scopus 로고
    • High-dose bicalutamide for androgen-independent prostate cancer: Effect of prior hormone therapy
    • Joyce R et al. High-dose bicalutamide for androgen-independent prostate cancer: effect of prior hormone therapy. J Urology 1998; 159: 149-153.
    • (1998) J Urology , vol.159 , pp. 149-153
    • Joyce, R.1
  • 78
    • 0030811758 scopus 로고    scopus 로고
    • Bicalutamide for advanced prostate cancer: The natural versus treated history of disease
    • Scher HI et al. Bicalutamide for advanced prostate cancer: the natural versus treated history of disease. J Clin Oncol 1997; 15: 2928-2938.
    • (1997) J Clin Oncol , vol.15 , pp. 2928-2938
    • Scher, H.I.1
  • 79
    • 0029619536 scopus 로고    scopus 로고
    • Hormone and antihormone withdrawal: Implications for the management of androgen-independent prostate cancer
    • Scher HI, Zhang ZF, Nantis D, Kelly VVK. Hormone and antihormone withdrawal: implications for the management of androgen-independent prostate cancer. Urology 1996; 47 (Suppl 1A): 61-69.
    • (1996) Urology , vol.47 , Issue.SUPPL. 1A , pp. 61-69
    • Scher, H.I.1    Zhang, Z.F.2    Nantis, D.3    Kelly, V.V.K.4
  • 80
    • 0031001274 scopus 로고    scopus 로고
    • Prostate specific antigen decreases after withdrawal of antiandrogen therapy with bicalutamide or flutamide in patients receiving combined androgen blockade
    • Schellhammer P et al. Prostate specific antigen decreases after withdrawal of antiandrogen therapy with bicalutamide or flutamide in patients receiving combined androgen blockade. J Urol 1997; 157: 1731-1735.
    • (1997) J Urol , vol.157 , pp. 1731-1735
    • Schellhammer, P.1


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