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Volumn 1, Issue 5, 1999, Pages 745-747

Novel 2,2-bipyridine ligand for palladium-catalyzed regioselective carbonylation

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EID: 0000305384     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol990123s     Document Type: Article
Times cited : (38)

References (15)
  • 9
    • 0033531994 scopus 로고    scopus 로고
    • (c) After we finished our experiments, two related papers published: Chambers, R. J.; Marfat, A. Synth. Commun. 1997, 515. Najiba, D.; Carpentier, J.-F.; Castanet, Y.; Biot, C.; Brocard, J.; Mortreux, A. Tetrahedron Lett. 1999, 40, 3719.
    • (1997) Synth. Commun. , pp. 515
    • Chambers, R.J.1    Marfat, A.2
  • 12
    • 85034139045 scopus 로고    scopus 로고
    • D & O Chemicals, Inc. 401 South Van Brunt Street, Englewood, NJ 07631
    • D & O Chemicals, Inc. 401 South Van Brunt Street, Englewood, NJ 07631.
  • 14
  • 15
    • 85034134861 scopus 로고    scopus 로고
    • 2, 5.0 g (32 mmol) of 2,2-bipyridine, 2.5 L of toluene, 127 mL (1.1 mol) of aniline, and 194 mL (1.4 mol) of DBU. The autoclave was sealed, evacuated, purged with nitrogen, and charged with CO to 80 psi. The mixture was heated to 65°C for about 40 h while keeping the pressure at 80 psi, cooled to 25°C, and filtered through a pad of Celite with aid of water. The layers were separated, and the organic layer was concentrated. Crystallization of the residue from 2-PrOH gave the desired amide in 76-82% isolated yield.The purity of the isolated product was >98% and the solution yield was 90% as determined by HPLC
    • 2, 5.0 g (32 mmol) of 2,2-bipyridine, 2.5 L of toluene, 127 mL (1.1 mol) of aniline, and 194 mL (1.4 mol) of DBU. The autoclave was sealed, evacuated, purged with nitrogen, and charged with CO to 80 psi. The mixture was heated to 65°C for about 40 h while keeping the pressure at 80 psi, cooled to 25°C, and filtered through a pad of Celite with aid of water. The layers were separated, and the organic layer was concentrated. Crystallization of the residue from 2-PrOH gave the desired amide in 76-82% isolated yield.The purity of the isolated product was >98% and the solution yield was 90% as determined by HPLC.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.