New stable reagents for the nucleophilic trifluoromethylation. 1. Trifluoromethylation of carbonyl compounds with N-formylmorpholine derivatives

Organic Letters

Volumn 2, Issue 14, 2000, Pages 2101-2103

  Billard, T ^a   Bruns, S ^a   Langlois, B R ^a  

^a UNIVERSITÉ LYON 1   (France)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0000102197     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol005987o     Document Type: Article

References (14)

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14. Typical Procedure. To a solution of 3 (2 mmol) and the electrophile (1 mmol) in DME (1 mL) was added a catalytic amount (≈10% mol) of CsF (dried at 250°C and stored at 110°C). The mixture was heated at 80 °C for 5 h. Then, the crude mixture was directly purified by chromatography over silica gel.