Nonviral monocyte chemoattractant protein-1 gene transfer improves arteriogenesis after femoral artery occlusion

Gene Therapy

Volumn 11, Issue 23, 2004, Pages 1685-1693

  Muhs, A ^a,d   Lenter, M C ^b   Seidler, R W ^b   Zweigerdt, R ^a,d   Kirchengast, M ^a,d   Weser, R ^c   Ruediger, M ^a,d   Guth, Brian ^b  

^a Cardion AG   (Germany)

^b BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

^c Herzzentrum Coswig/Anhalt ^*  (Germany)

^d Kourion Therapeutics AG   (Germany)

Author keywords

Arteries; Collateral circulation; Minipig; Monocyte chemoattractant protein 1; Nonviral gene transfer

Indexed keywords

COMPLEMENTARY DNA; DNA; LIPOSOME; MONOCYTE CHEMOTACTIC PROTEIN 1;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA PRESSURE; ARTERY OCCLUSION; ARTICLE; BLOOD PRESSURE; BLOOD VESSEL; COLLATERAL CIRCULATION; CONDUCTANCE; CONTROLLED STUDY; DEVICE; DRUG DELIVERY SYSTEM; DRUG MECHANISM; FEMORAL ARTERY; GENE OVEREXPRESSION; GENE TRANSFER; HEMODYNAMICS; HINDLIMB; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RABBIT; STATISTICAL ANALYSIS; SWINE;

ANIMALS; ARTERIAL OCCLUSIVE DISEASES; CHEMOKINE CCL2; COLLATERAL CIRCULATION; DISEASE MODELS, ANIMAL; FEMORAL ARTERY; GENE EXPRESSION; GENE THERAPY; LIPOSOMES; PERIPHERAL VASCULAR DISEASES; PLASMIDS; POLYMERASE CHAIN REACTION; SWINE; SWINE, MINIATURE; TRANSFECTION; TRANSGENES;

ANIMALIA; ORYCTOLAGUS CUNICULUS; SUIDAE; SUS SCROFA;

EID: 9944220975     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3302360     Document Type: Article

References (38)

1. Dormandy JA, Rutherford RB. Management of peripheral arterial disease (PAD). TASC Working Group. TransAtlantic Inter-Society Concensus (TASC). J Vasc Surg 2000; 31: S1-S296.
2. Zhang ZG, Zhang L, Jiang Q, Chopp M. Bone marrow-derived endothelial progenitor cells participate in cerebral neovascularization after focal cerebral ischemia in the adult mouse. Circ Res 2002; 90: 284-288.
3. Asahara T et al. Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization. Circ Res 1999; 85: 221-228.
4. Risau W. Mechanisms of angiogenesis. Nature 1997; 386: 671-674.
5. van Royen N et al. Arteriogenesis: mechanisms and modulation of collateral artery development. J Nucl Cardiol 2001; 8: 687-693.
6. Scholz D et al. Ultrastructure and molecular histology of rabbit hind-limb collateral artery growth (arteriogenesis). Virchows Arch 2000; 436: 257-270.
7. Shyy YJ, Hsieh HJ, Usami S, Chien S. Fluid shear stress induces a biphasic response of human monocyte chemotactic protein 1 gene expression in vascular endothelium. Proc Natl Acad Sci USA 1994; 91: 4678-4682.
8. Scholz D et al. Expression of adhesion molecules is specific and time-dependent in cytokine-stimulated endothelial cells in culture. Cell Tissue Res 1996; 284: 415-423.
9. Walpola PL, Gotlieb AI, Cybulsky MI, Langille BL. Expression of ICAM-1 and VCAM-1 and monocyte adherence in arteries exposed to altered shear stress. Arterioscler Thromb Vasc Biol 1995; 15: 2-10.
10. Morigi M et al. Fluid shear stress modulates surface expression of adhesion molecules by endothelial cells. Blood 1995; 85: 1696-1703.
11. Arras M et al. Monocyte activation in angiogenesis and collateral growth in the rabbit hindlimb. J Clin Invest 1998; 101: 40-50.
12. Polverini PJ, Cotran PS, Gimbrone Jr MA, Unanue ER. Activated macrophages induce vascular proliferation. Nature 1977; 269: 804-806.
13. Oppenheim JJ, Zachariae CO, Mukaida N, Matsushima K. Properties of the novel proinflammatory supergene 'intercrine' cytokine family. Annu Rev Immunol 1991; 9: 617-648.
14. Mantovani A et al. The origin and function of tumor-associated macrophages. Immunol Today 1992; 13: 265-270.
15. Miller MD, Krangel MS. Biology and biochemistry of the chemokines: a family of chemotactic and inflammatory cytokines. Crit Rev Immunol 1992; 12: 17-46.
16. Boisvert WA. Modulation of atherogenesis by chemokines. Trends Cardiovasc Med 2004; 14: 161-165.
17. Buschmann I, Heil M, Jost M, Schaper W. Influence of inflammatory cytokines on arteriogenesis. Microcirculation 2003; 10: 371-379.
18. Ito WD et al. Monocyte chemotactic protein-1 increases collateral and peripheral conductance after femoral artery occlusion. Circ Res 1997; 80: 829-837.
19. Deindl E et al. Role of ischemia and of hypoxia-inducible genes in arteriogenesis after femoral artery occlusion in the rabbit. Circ Res 2001; 89: 779-786.
20. Kamihata H et al. Implantation of bone marrow mononuclear cells into ischemic myocardium enhances collateral perfusion and regional function via side supply of angioblasts, angiogenic ligands, and cytokines. Circulation 2001; 104: 1046-1052.
21. White FC, Carroll SM, Magnet A, Bloor CM. Coronary collateral development in swine after coronary artery occlusion. Circ Res 1992; 71: 1490-1500.
22. Hoefer IE et al. Time course of arteriogenesis following femoral artery occlusion in the rabbit. Cardiovasc Res 2001; 49: 609-617.
23. Voskuil M et al. Modulation of collateral artery growth in a porcine hindlimb ligation model using MCP-1. Am J Physiol Heart Circ Physiol 2003; 284: H1422-H1428.
24. Buschmann IR et al. GM-CSF: a strong arteriogenic factor acting by amplification of monocyte function. Atherosclerosis 2001; 159: 343-356.
25. Muhs A et al. Preclinical evaluation of inducible nitric oxide synthase lipoplex gene therapy for inhibition of stent-induced vascular neointimal lesion formation. Hum Gene Ther 2003; 14: 375-383.
26. Laham RJ et al. Intrapericardial delivery of fibroblast growth factor-2 induces neovascularization in a porcine model of chronic myocardial ischemia. J Pharmacol Exp Ther 2000; 292: 795-802.
27. Sato K et al. Efficacy of intracoronary versus intravenous FGF-2 in a pig model of chronic myocardial ischemia. Ann Thorac Surg 2000; 70: 2113-2118.
28. Takeshita S et al. Therapeutic angiogenesis following arterial gene transfer of vascular endothelial growth factor in a rabbit model of hindlimb ischemia. Biochem Biophys Res Commun 1996; 227 628-635.
29. Isner JM et al. Arterial gene transfer for therapeutic angiogenesis in patients with peripheral artery disease. Hum Gene Ther 1996; 7: 959-988.
30. Vale PR et al. Randomized, single-blind, placebo-controlled pilot study of catheter-based myocardial gene transfer for therapeutic angiogenesis using left ventricular electromechanical mapping in patients with chronic myocardial ischemia. Circulation 2001; 103: 2138-2143.
31. Bratton DL et al. Granulocyte-macrophage colony-stimulating factor contributes to enhanced monocyte survival in chronic atopic dermatitis. J Clin Invest 1995; 95: 211-218.
32. Seiler C et al. Promotion of collateral growth by granulocyte-macrophage colony-stimulating factor in patients with coronary artery disease: a randomized, double-blind, placebo-controlled study. Circulation 2001; 104: 2012-2017.
33. Huo Y et al. The chemokine KC, but not monocyte chemoattractant protein-1, triggers monocyte arrest on early atherosclerotic endothelium. J Clin Invest 2001; 108: 1307-1314.
34. Namiki M et al. Local overexpression of monocyte chemoattractant protein-1 at vessel wall induces infiltration of macrophages and formation of atherosclerotic lesion: synergism with hypercholesterolemia. Arterioscler Thromb Vasc Biol 2002; 22: 115-120.
35. van Royen N et al. Local monocyte chemoattractant protein-1 therapy increases collateral artery formation in apolipoprotein E-deficient mice but induces systemic monocytic CD11b expression, neointimal formation, and plaque progression. Circ Res 2003; 92 218-225.
36. Ni W et al. New anti-monocyte chemoattractant protein-1 gene therapy attenuates atherosclerosis in apolipoprotein E-knockout mice. Circulation 2001; 103: 2096-2101.
37. Lu ZH et al. The promiscuous chemokine binding profile of the Duffy antigen/receptor for chemokines is primarily localized to sequences in the amino-terminal domain. J Biol Chem 1995; 270 26239-26245.
38. Dozois CM et al. A reverse transcription-polymerase chain reaction method to analyze porcine cytokine gene expression. Vet Immunol Immunopathol 1997; 58: 287-300.