Validation of the heat treatment step used in the production of diaspirin crosslinked hemoglobin (DCLHb®) for viral inactivation - Effect of crosslinking

Artificial Cells, Blood Substitutes, and Immobilization Biotechnology

Volumn 25, Issue 6, 1997, Pages 521-526

  Azari, M ^a   Catarello, J ^a   Burhop, K ^a   Camacho, T ^a   Ebeling, A ^a   Estep, T ^a   Guzder, S ^a   Krause, K ^a   Marshall, T ^a   Rohn, K ^a   Sarajari, R ^a   Boose, J A ^b   Gauvin, G ^b   Horner, R ^b   Lu, B ^b   Pearson, L ^b   Vacante, D ^b  

^a BAXTER HEALTHCARE CORPORATION   (United States)

^b Microbiological Associates Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CROSSLINKING; HEAT TREATMENT;

STROMA FREE HEMOGLOBIN; VIRAL INACTIVATION;

HEMOGLOBIN;

4 (2 HYDROXYETHYL) 1 PIPERAZINEETHANESULFONIC ACID; DIASPIRIN CROSSLINKED HEMOGLOBIN; FUMARIC ACID DERIVATIVE; HEMOGLOBIN; HEMOGLOBIN DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BOVINE DIARRHEA VIRUS; CHEMICAL REACTION; CROSS LINKING; HEAT TREATMENT; PARVOVIRUS; REACTION TIME; TEMPERATURE; VIRUS INACTIVATION;

BOVINAE; BOVINE VIRAL DIARRHEA VIRUS 1; PARVOVIRUS; PORCINE PARVOVIRUS; SUIDAE;

EID: 9844262799     PISSN: 10731199     EISSN: None     Source Type: Journal    
DOI: 10.3109/10731199709117449     Document Type: Article

References (3)

1. Azari, M., Rohn, K., Picken, J., Diaspirin Crosslinked Hemoglobin (DCLHb™): Characterization of the process and the product manufactured GMP requirements for clinical studies (1994), Art., Blood Subs., and Immob. Biotech., 22(3), 701-708.
2. Farmer, M., Ebeling, A., Marshall, T., Hauck, W., Sun, C.S., White, E., and Long, Z., Validation of Virus Inactivation by Heat Treatment in the Manufacture of Diaspirin Crosslinked Hemoglobin. Biomat Artif Cells Immobil Biotech 1992; 20(2-4), 429-433
3. Azari, M., Ebeling, A., Baker, R., Burhop, K., Camacho, T., Catarello, J., Estep, T., Guzder, S., Marshall, T., Rohn, K., Sarajari, R., Validation of Virus Inactivation by Heat Treatment in the Manufacture of Diaspirin Crosslinked Hemoglobin (DCLHB™) for Viral Inactivation (Manuscript is being submitted for publication simultaneously).