Tonic block of the Na+ current in single atrial and ventricular/guinea-pig myocytes, by a new antiarrhythmic drug, Ro 22-9194

Fundamental and Clinical Pharmacology

Volumn 11, Issue 5, 1997, Pages 402-407

  Hiroe, K ^a   Hisatome, I ^a   Tanaka, Y ^a   Ahmmed, G U ^a   Sasaki, N ^a   Shimoyama, M ^a   Tsuboi, M ^a   Inoue, Y ^a   Manabe, I ^a   Yamamoto, Y ^a   Ohtahata, A ^a   Kinugawa, T ^a   Ogino, K ^a   Igawa, O ^a   Yoshida, A ^a   Shigemasa, C ^a   Sato, R ^b  

^a TOTTORI UNIVERSITY   (Japan)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Atrial myocytes; Modulated receptor hypothesis; N+ current; Ro 22 09194; Tonic block; Ventricular myocytes

Indexed keywords

ANTIARRHYTHMIC AGENT; RO 22 9194; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIARRHYTHMIC ACTIVITY; ARTICLE; CELL MEMBRANE POTENTIAL; CONTROLLED STUDY; GUINEA PIG; HEART ATRIUM; HEART MUSCLE CELL; HEART VENTRICLE; HYPOTHESIS; NONHUMAN; PRIORITY JOURNAL; SODIUM CURRENT; VOLTAGE CLAMP;

EID: 9844259471     PISSN: 07673981     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1472-8206.1997.tb00202.x     Document Type: Article

References (11)

1. Bean BP, Cohen AJ, Tsien RW. Lidocaine block of sodium channels. J Gen Physiol 1983;81:613-42
2. Campbell TJ. Kinetics of onset of rate-dependent effects of Class 1 antiarrhythmic drugs are important in determining their effects on refractoriness in guinea-pig ventricle, and provide a theoretical basis for their subclassification. Cardiovasc Res 1983;17:344-52
3. Colatsky TJ, Tsien RW. Sodium channels in rabbit cardiac Purkinje fibers. Nature 1979;278:265-8
4. 2+ exchange current in single guinea-pig ventricular cells. J Physiol 1989;410:227-49
5. Hisatome I, Matsuoka S, Miyamoto J, Sawaguchi M, Omodani H, Osaki S et al. Blocking effect of 1389-S on the sodium current in isolated guinea-pig ventricular myocytes. Eur J Pharmacol 1990;179:447-51
6. Hondeghem LM, Katzung BG. Time- and voltage-dependent interactions of antiarrhythmic drugs with sodium channel. Biochim Biophys J 1977;472:373-98
7. Kodama I, Honjo H, Kamiya K, Toyama I. Two types of sodium channel block by Class-1 antiarrhythmic drugs studied by using Vmax of action potential in single ventricular myocytes. J Mol Cell Cardiol 1990;22:1-12
8. Maruyama K, Kodama I, Anno T, Suzuki R, Toyama J. Electrophysiological effects of Ro 22-9194, a new antiarrhythmic agent, on guinea-pig ventricular cells. British J Pharmacol 1995;114:19-26
9. Murakami M, Furukawa Y, Karasawa Y, Ren L, Chiba S. Cardiovascular effects of 2-amino-N-(2,6-dimethylphenyl)-N-[3-(3-pyridyl) propyl] propionamide dihydrochloride (Ro 22-9194) in the isolated, cross-perfused atrium of the dog. Jpn Heart J 1990;31:731-9
10. Murakami M, Furukawa Y, Karasawa Y, Ren L, Chiba S. Cardiovascular effects of R- and S-enantiomers of Ro 22-9194, (2R)-2-amino-N-(2,6-dimethylphenyl)-N-3-(3-pyridyl) propyl) propionamide D-tartrate and (2S)-2-amino-N-(2,6-dimethylphenyl)-N-[3-(3-pyridyl) propyl] propionamide L-tartrate, in dog heart preparations. J Cardiovasc Pharmacol 1992;20:165-71
11. Sato R, Hisatome I, Tanaka Y, Sasaki N, Kotake H, Mashiba H, Katori R. Aprindine blocks the sodium current in guinea-pig ventricular myocytes. Naunyn-Schmiederberg's Arch Pharmacol 1991;344:331-6