2,6-di-tert-butylphenols : A new class of potent and selective PGHS-2 inhibitor

Inflammation Research

Volumn 46, Issue SUPPL. 2, 1997, Pages

  Song, Y ^a   Connor, D T ^a   Sorenson, R J ^a   Doubleday, R ^a   Sercel, A D ^a   Unangst, P C ^a   Gilbertsen, R B ^a   Chan, K ^a   Bornemeier, D A ^a   Dyer, R D ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,6 DI TERT BUTYLPHENOL; 5 (3,5 DI TERT BUTYL 4 HYDROXYBENZYLIDENE) 2 METHOXYIMINO 4 THIAZOLONE; PD 167065; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

CONFERENCE PAPER; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME ASSAY;

CYCLOOXYGENASE INHIBITORS; ENZYME INHIBITORS; HUMANS; PHENOLS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; THIAZOLES;

EID: 9844255580     PISSN: 10233830     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (8)

1. Lombardino G. Nonsteroidal antiinflammatory drugs. New York: John Wiley & Sons, 1985.
2. Allison MC, Howatson AG, Torrance CJ, Lee FD, Russell RI. Gastrointestinal damage associated with the use of nonsteroidal antiinflammatory drugs. New Engl J Med 1992;327:749-34.
3. 2 synthases. Chem Biol 1995;2:343-50.
4. Isakson P, Seibert K, Masferrer J, Salvemini D, Lee L, Needleman P. Discovery of a better aspirin. Advances in prostaglandin, thromboxane, and leukotriene research. In: Samuelson B, editor. vol. 23. New York: Raven Press, 1995.
5. Chan CC, Boyce S, Brideau C, Ford-Hutchinson AW, Gordon R, Guay D, et al. Pharmacology of a selective cyclooxygenase-2 inhibitor, L-745,337: a novel nonsteroidal anti-inflammatory agent with an ulcerogenic sparing effect in rat and nonhuman primate stomach. J Pharm Exper Ther 1993;274:1531-7.
6. Unangst PC, Connor DT, Cetenko WA, Sorenson RJ, Kostlan CR, Sircar JC, et al. Synthesis and biological evaluation of 5-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]oxazoles, thiazoles, andimidazoles: Novel dual 5-lipoxygenase and cyclooxygenase inhibitors with antiinflammatory activity. J Med Chem 1994;37:322-8.
7. Dyer RD, Bornemeier D, Doubleday R, Song Y, Guglietta A, Laemont K, et al. Novel class of slow-equilibrating, orally active PGHS-2 inhibitors. Poster presentation, 8th IRA meeting: 1996 October, Hershey, PA.
8. Chan K, Song Y, Flory C, Gilhertsen RB. Establishment of cell-based systems and their utilization in the evaluation of PGHS-1 and -2 selective inhibitors. Poster presentation, 8th IRA meeting: 1996 October, Hershey, PA.