From indomethacin to a selective COX-2 inhibitor: Development of indolalkanoic acids as potent and selective cyclooxygenase-2 inhibitors

Advances in Experimental Medicine and Biology

Volumn 407, Issue , 1996, Pages 73-78

  Lau, C K ^a   Black, W C ^a   Belley, M ^a   Chan, C ^a   Charleson, S ^a   Denis, D ^a   Gauthier, J Y ^a   Gordon, R ^a   Quay, D ^a   Hamel, P ^a   Kargman, S ^a   Leblanc, Y ^a   Mancini, J ^a   Ouellet, M ^a   Percival, D ^a   Prasit, P ^a   Roy, P ^a   Skorey, K ^a   Tagari, P ^a   Vickers, P ^a   Wong, E ^a   more..

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CARRAGEENAN; CYCLOOXYGENASE 2 INHIBITOR; INDOMETACIN; NONSTEROID ANTIINFLAMMATORY AGENT;

ANTIINFLAMMATORY ACTIVITY; CONFERENCE PAPER; DISEASE ACTIVITY; GASTROINTESTINAL TOXICITY; HYPOTHESIS; KIDNEY FUNCTION; OSTEOSARCOMA; PRIORITY JOURNAL; STOMACH FUNCTION; TUMOR CELL LINE;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CARRAGEENAN; CHROMIUM RADIOISOTOPES; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; DIGESTIVE SYSTEM; EDEMA; FECES; FEVER; INDOMETHACIN; ISOENZYMES; MEMBRANE PROTEINS; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; NEOPLASM PROTEINS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; TUMOR CELLS, CULTURED;

EID: 9844253895     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Conference Paper

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