Sequential development of myelodysplasia and acute myeloid leukemia but with no karyotypic evolution after autografting in a patient with Philadelphia positive acute lymphoblastic leukemia

Leukemia and Lymphoma

Volumn 26, Issue 5-6, 1997, Pages 625-628

  Saso, R ^a   Zomas, A ^a   Hamblin, M ^a   Dunlop, L ^a   Swansbury, G J ^a   Min, T ^a   Singhal, S ^a   Powles, R ^a   Treleaven, J ^a   Mehta, J ^a  

^a ROYAL MARSDEN HOSPITAL   (United Kingdom)

Author keywords

Acute lymphoblastic leukemia; Acute myeloid leukemia; Autologous blood stem cell transplantation; Myelodysplastic syndrome; Philadelphia chromosome

Indexed keywords

ALPHA2B INTERFERON; HYDROXYUREA; MELPHALAN; MERCAPTOPURINE; METHOTREXATE;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ADULT; ADVERSE DRUG REACTION; ARTICLE; AUTOGRAFT; BLAST CELL; CASE REPORT; CENTRAL NERVOUS SYSTEM METASTASIS; FEMALE; HUMAN; INTRATHECAL DRUG ADMINISTRATION; KARYOTYPE; LYMPHOID CELL; MYELODYSPLASIA; PANCYTOPENIA; PHILADELPHIA 1 CHROMOSOME; PRIORITY JOURNAL; STEM CELL TRANSPLANTATION;

EID: 9844251772     PISSN: 10428194     EISSN: None     Source Type: Journal    
DOI: 10.3109/10428199709050900     Document Type: Article

References (23)

1. Clark, S. S., McLaughlin, J., Timmons, M., et al. Expression of a distinctive BCR-ABL oncogene in Ph-positive acute lymphocytic leukemia (ALL). Science, 239, 775-777.
2. Hermans, A., Gow, J., Selleri, L., et al. (1988). bcr-abl oncogene activation in Philadelphia chromosome-positive acute lymphoblastic leukemia. Leukemia, 2, 628-633.
3. Kantarjian, H. M., Talpaz, M., Dhingra, K., et al. (1991). Significance of the p210 versus p190 molecular abnormalities in adults with Philadelphia chromosome-positive acute leukemia. Blood, 78, 2411-2418.
4. Bloomfield, C. D., Godlman, A. I., Alimena, G., et al. (1986). Chromosomal abnormalities identify high-risk and low-risk patients with acute lymphoblastic leukemia. Blood, 67, 415-420.
5. Fletcher, J. A., Lynch, E. A., Kimball, V. M., Donnelly, M., Tantravahi, R. and Sallari, S. E. (1991). Translocation (9;22) is associated with extremely poor prognosis in intensively treated children with acute lymphoblastic leukemia. Blood, 77, 435-439.
6. Kantarjian, H. M., Talpaz, M., Dhingra, K., et al. (1991). Significance of the p210 versus p190 molecular abnormalities in adults with Philadelphia chromosome-positive acute leukemia. Blood, 78, 2411-2418.
7. Dunlop, L., Powles, R., Singhal, S., et al. (1996). Bone marrow transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia. Bone Marrow Transplant., 17, 365-369.
8. Grigg, A. P. (1993). Approaches to the treatment of Philadelphia-positive acute lymphoblastic leukemia. Bone Marrow Transplant, 12, 431-435.
9. 1-negative ALL. Acta Haematol., 81, 217-218.
10. Alien, P., Morgan, G. J. and Weidemann, L. M. (1992). Philadelphia chromosome-positive leukemia: the translocated genes and their gene products. Balliere's Clin. Haematol., 5, 897-929.
11. Verhoef, G., Meeus, P., Stul, M., et al. (1992). Cytogenetic and molecular studies of the Philadelphia translocation in myelodysplastic syndromes: report of two cases and review of literature. Cancer Genet. Cytogenet., 11, 233-248.
12. Seeker-Walker, L. M (1984). The prognostic implications of chromosomal findings in acute lymphoblastic leukaemia. Cancer Genet. Cytogenet., 11, 233-248.
13. Raimondi, S., Pui, C. H., Head, D. R., Rivera, G. K. and Behm, F. G. (1993). Cytogenetically different leukemic clones at relapse of childhood acute lymphoblastic leukemia. Blood, 82, 576-580.
14. Stass, S., Mirro, J., Melvin, S., Pui, C. H., Murphy, S. B. and Williams, D. (1984). Lineage switch in acute leukemia. Blood, 64, 701-706.
15. Pui, C. H., Behm, F. G., Raimondi, S. C., et al. (1989). Secondary acute myeloid leukemia in children treated for acute lymphoid leukemia. N. Engl. J. Med., 321, 136-142.
16. Seeker-Walker, L. M. and Craig, J. M. (1993). Prognostic implications of breakpoint and lineage heterogeneity in Philadelphia-positive acute lymphoblastic leukemia: a review. Leukemia, 7, 147-151.
17. Catovsky, D. (1979). Ph-positive acute leukaemia and chronic granulocytic leukaemia: one or two diseases. Br. J. Haematol, 42, 493-498.
18. Gale, R. P. and Butturini, A. (1990). Ph-chromosome positive acute leukemias and acute phase CML: one or two diseases? Two. Leukemia Res., 14, 295-297.
19. Quo, J. Q., Hirsch-Ginsberg, C. F., Xian, Y. M., et al. (1993). Acute lymphoid leukemia molecular phenotype in a patient with benign-phase chronic myelogenous leukemia. Hematol. Pathol, 7, 91-106.
20. Melo, J. V., Myint, H., Gallon, D. A. G. and Goldman, J. M. (1994). p190 BCR-ABL chronic myeloid leukaemia: the missing link with chronic myelomonocytic leukaemia?, Leukemia, 8, 208-211.
21. Tien, H. F., Wang, C. H., Chuang, S. M., et al. (1992). Characterization of Philadelphia-chromosome-positive acute leukemia by clinical, imrmmocytochemical and gene analysis. Leukemia, 6, 907-914.
22. Voncken, J. W., Kaartinen, V., Pattengale, P. K., Germeraad, W. T. V., Groffen, J. and Heistercamp, N. (1995). BCR/ABL p210 and p190 cause distinct leukemia in transgenic mice. Blood, 86, 4603-4611.
23. Skuse, G R. and Ludlow, J. W. (1995). Tumour suppressor genes in disease and therapy. Lancet, 345, 902-906.