Coexistence of an autonomously functioning thyroid nodule in a patient with Graves' disease: An unusual presentation of Marine-Lenhart syndrome

Endocrine Journal

Volumn 44, Issue 4, 1997, Pages 571-574

  Nishikawa, Mitsushige ^a   Yoshimura, Masayoshi ^a   Yoshikawa, Norio ^a   Toyoda, Nagaoki ^a   Yonemoto, Toshinaga ^a   Ogawa, Yoshifumi ^a   Mori, Shigeki ^a   Tabata, Sakuyoshi ^a   Tokoro, Toshiko ^a   Sakaguchi, Noriko ^a   Inada, Mitsuo ^a  

^a KANSAI MEDICAL UNIVERSITY   (Japan)

Author keywords

Autonomously functioning thyroid nodule(AFTN); Graves' disease; Marine Lenhart syndrome; Scintigraphy; Thyrotoxicosis

Indexed keywords

ADULT; ARTICLE; CASE REPORT; DRUG RECEPTOR BINDING; FEEDBACK SYSTEM; FEMALE; FUNCTIONAL ASSESSMENT; GRAVES DISEASE; HUMAN; HYPERTHYROIDISM; SCINTIGRAPHY; SYNDROME; THYROID FUNCTION; THYROID NODULE; THYROIDECTOMY; THYROTOXICOSIS;

EID: 9844242123     PISSN: 09188959     EISSN: None     Source Type: Journal    
DOI: 10.1507/endocrj.44.571     Document Type: Article

References (17)

1. Kosugi S, Shenker A, Mori T (1994) Constitutive activation of cyclic AMP but not phosphatidylinositol signaling caused by four mutations in the 6th transmembrane helix of the human thyrotropin receptor. FEBS Letters 356: 291-294.
2. Nagayama Y, Kaufman KD, Seto P, Rapoport B (1989) Molecular cloning, sequence and functional expression of the cDNA for the human thyrotropin receptor. Biochem Biophys Res Commun 195: 1184-1190.
3. Rosenfield PS, Purgos-Vasques F (1970) Development of Graves' disease in a patient with an autonomous thyroid nodule. South Med J 63: 549-551.
4. Bendezu R, Wieland RG, Tang P, Levine B (1977) Unusual events preceding hyperthyroidism with diffuse goiter. Arch Intern Med 137: 1023-1025.
5. Freeman JS, Ertel NH, McA'Nulty JA, Khan MY (1983) Graves' disease following resection of an autonomous solitary thyroid adenoma. J Med Soc NJ 80: 444.
6. Vento JA, Salvin JD Jr, Readon GE, Spencer RP (1986) Graves' disease initial presentation with exophthalmos and solitary hot nodule. Clin Nucl Med 11: 404.
7. Smyth PPA, Neylan D, McMullan NM, Smith DF, McKenna TJ (1988) Sequential presentation of a case of hyperthyroidism with autonomously functioning nodules and Graves' disease in the presence of IgG thyroid stimulators. Acta Endocrinol (Copenh) 118: 474-478.
8. Charkes ND (1972) Graves' disease with functioning nodules (Marine-Lenhart syndrome). J Nucl Med 13: 885-892.
9. Chandramouly B, Mann D, Cunningham RP, Giegerich E (1992) Marine-Lenhart syndrome: Graves' disease with pooly functioning nodules. Clin Nucl Med 17: 905-906.
10. Ikekubo K, Hino M, Ito H, Otani M, Shimozato S, Nasu K, Hatabu Y, Yamaguchi H, Sakai Y, Ishihara T, Waseda N, Mori T (1988) The development of a solitary toxic thyroid nodule following Graves' disease. Clin Nucl Med 13: 748-750.
11. Tamai H, Nagai K, Ishimoto J, Matsubayashi S, Matsuzuka F, Miyauchi A, Kuma K, Nagataki S (1990) Unusual thyroid scintigrams in Plummer's disease during methymazole therapy. Conversion of hot to hypofunctioning nodules. Clin Nucl Med 15: 465-167.
12. Skellern GG, Knight BI, Low CK, Alexander WD, McLarty DG, Kalk WJ (1980) The pharmacokinetics of methymazole after oral administration of carbimazole and methymazole in hyperthyroid patients. Br J Clin Pharmacol 9: 137-143.
13. Cavalieri RR, McDougall IR (1996) In vivo isotopic tests and imaging. In: Braverman LE, Utiger RD (eds) The Thyroid. 7th ed, 352-375.
14. Parma J, Duprez L, Van Sande J, Cochaux P, Gervy C, Mockel J, Dumont J, Vassart G (1993) Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas. Nature 365: 649-651.
15. Procellini A, Ciullo I, Laviola L, Amabile G, Fenzi G, Avvedimento VE (1994) Novel mutations of thyrotropin receptor gene in thyroid hyperfunctioning adenomas. Rapid identification by fine needle aspiration biopsy. J Clin Endocrinol Metab 79: 657-661.
16. Paschke R, Tonacchera M, Van Sande J, Parma J, Vassart G (1994) Identification and functional characterization of two new somatic mutation causing constitutive activation of the thyrotropin receptor in hyperfunctioning autonomous adenomas of the thyroid. J Clin Endocrinol Metab 79: 1785-1789.
17. Takeshita A, Nagayama Y, Yokoyama N, Ishikawa N, Ito K, Yamashita T, Obara T, Murakami Y, Kuma K, Takamatsu J, Osawa N, Nagataki S (1995) Rarity of oncogenic mutations in the thyrotropin receptor of autonomously functioning thyroid nodules in Japan. J Clin Endocrinol Metab 80: 2607-2611.