Cisplatin, gemcitabine and vinorelbine in locally advanced or metastatic non-small-cell lung cancer: A phase I study

Annals of Oncology

Volumn 8, Issue 10, 1997, Pages 1045-1048

  Frasci, G ^a   Panza, N ^b   Cornella, P ^a   Nicolella, G P ^b   Natale, M ^b   Pacilio, C ^b   Gravina, A ^a   Caputi, V ^a   Botti, G ^a   Comella, G ^a  

^a NATIONAL CANCER INSTITUTE   (Italy)

^b CARDARELLI HOSPITAL   (Italy)

Author keywords

Cisplatin; Gemcitabine; NSCLC; Phase I study; Vinorelbine

Indexed keywords

CISPLATIN; GEMCITABINE; NAVELBINE;

ADULT; ADVANCED CANCER; AGED; ALOPECIA; ANEMIA; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER SURVIVAL; CLINICAL ARTICLE; CLINICAL TRIAL; DRUG RESPONSE; FATIGUE; FEMALE; GASTROINTESTINAL SYMPTOM; HUMAN; LUNG NON SMALL CELL CANCER; MALE; NEPHROTOXICITY; NEUTROPENIA; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; THROMBOCYTOPENIA;

ADULT; AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CARCINOMA, NON-SMALL-CELL LUNG; CISPLATIN; DEOXYCYTIDINE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; LUNG NEOPLASMS; MALE; MIDDLE AGED; TREATMENT OUTCOME; VINBLASTINE;

EID: 9844228523     PISSN: 09237534     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1008218306355     Document Type: Article

References (10)

1. Comis RL, Friedland DM. New chemotherapy agents in the treatment of advanced non-small-cell lung cancer: An update including data from the Seventh World Conference on Lung Cancer. Lung Cancer 1995; 12: S63-9 (Suppl 2).
2. Depierre A, Lemarie E, Dabouis G et al. A phase II study of navelbine (vinorelbine) in the treatment of non-small cell lung cancer. Am J Clin Oncol 1991; 14: 115-9.
3. Le Chevalier T, Brisgand D, Douillard JY et al. Randomized study of vinorelbine and cisplatin versus vindesine and cisplatin versus vinorelbine alone in advanced non-small-cell lung cancer: Results of a European Multicenter Trial including 612 patients. J Clin Oncol 1994; 12: 360-6.
4. Hertel LW, Broder GB, Croin JS, et al. Evaluation of the antitumor activity of gemcitabine (2′, 2′ difluorodeoxycytidine). Cancer Res 1990; 50: 4417-22.
5. Anderson H, Lund B, Back F et al. Single-agent activity of weekly gemcitabine in advanced non-small-cell lung cancer: A phase II study. J Clin Oncol 1994; 12: 1821-6.
6. Gatzmeier U, Sheperd FA, Le Chevalier T et al. Activity of gemcitabine in patients with non-small-cell lung cancer: A multicentre extended phase II study. Eur J Cancer 1996; 32A: 243-8.
7. Crinò L, Scagliotti G, Marangolo M et al. Cisplatin-gemcitabine combination in advanced non-small-cell lung cancer: A phase II study. J Clin Oncol 1997; 15: 297-303.
8. Abratt RP, Bezwoda WR, Goedhals L and Hacking DJ. Weekly gemcitabine with monthly cisplatin: Effective chemotherapy for advanced non-small-cell lung cancer. J Clin Oncol 1997; 15: 744-50.
9. Eli Lilly. New Drug Submission. Canadian Comprehensive Summary Clinical Synopsis, Part 3, Vol. 1, 1994, p. 938.
10. Souquet PJ, Fournel P, Bohas CH et al. Cisplatin, ifosfamide, with increasing dosages of vinorelbine (NIP) in advanced non-small-cell lung cancer (NSCLC). Lung Cancer 1994; 11: 115(Suppl 1).