Excessive proliferation matched by excessive apoptosis in myelodysplastic syndromes: The cause-effect relationship

Leukemia and Lymphoma

Volumn 27, Issue 1-2, 1997, Pages 111-118

  Raza, Azra ^a   Alvi, Sairah ^a   Borok, Raphael Z ^b   Span, Lambert ^a   Parcharidou, Agapi ^c   Alston, Devena ^d   Rifkin, Shelby ^e   Robin, Erwin ^f   Shah, Rohit ^g   Gregory, Stephanie A ^a  

^a RUSH CANCER INSTITUTE   (United States)

^b RUSH UNIVERSITY MEDICAL CENTER   (United States)

^c UNIVERSITY OF ATHENS   (Greece)

^d LaPorte Cancer Treatment Center   (United States)

^e NORTHWEST COMMUNITY HOSPITAL   (United States)

^f Ingalls Memorial Hospital   (United States)

^g Lake Forest Hospital   (United States)

Author keywords

Apoptosis; Myelodysplastic syndromes; Proliferation; Signal antonymy; Tumor necrosis factor alpha

Indexed keywords

BROXURIDINE; DNA FRAGMENT; IDOXURIDINE;

APOPTOSIS; ARTICLE; BONE MARROW; BONE MARROW BIOPSY; CELL CYCLE; CELL CYCLE S PHASE; CELL KINETICS; CELL PROLIFERATION; CONTROLLED STUDY; DNA SYNTHESIS; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MYELODYSPLASTIC SYNDROME; PANCYTOPENIA; PRIORITY JOURNAL;

EID: 9844226194     PISSN: 10428194     EISSN: None     Source Type: Journal    
DOI: 10.3109/10428199709068277     Document Type: Article

References (26)

1. Resegotti, L. (1993). The nature and natural history of myelodysplasia. Haematologica, 25(3), 191-204.
2. Raza, A., Preisler, H. D., Day, R., Yasin, Z., White, L. M., Lykins, J., Barcos, M., Bennett, J., Browman, G., Goldberg, J., Grunwald, H., Larson, R. and Vogler, R. (1990). Direct relationship between remission duration in acute myeloid leukemia and cell cycle kinetics. A Leukemia Intergroup Study. Blood, 76(11), 2191-2197.
3. Wijsman, J. H., Jonker, R. R., Keijzer, R., Van de Velde, C. J. H., Cornelisse, C. J. and Dierendonck, J. H. V. (1993). A new method to detect apoptosis in paraffin sections: In situ endlabeling of fragmented DNA. Journal of Histochemistry and Cytochemistry, 41, 7-12.
4. Mundle, S., Iftikhar, A., Shetty, V., Dameron, S., Wright-Quinones, V., Marcus, B., Loew, J., Gregory, S. and Raza, A. (1994). Novel in situ double-labeling for simultaneous detection of proliferation and apoptosis. Journal of Histochemistry Cytochemistry, 42(12), 1533-1537.
5. Raza, A., Mundle, S., Iftikhar, A., Gregory, S., Marcus, B., Khan, Z. and Alvi, S., Shetty, V., Dameron, S., Wright, V., Adler, S., Loew, J., Schott, S., Ali, N. and Preisler, H. (1995). Simultaneous assessment of cell kinetics and programmed cell death in bone marrow biopsies of myelodysplastics reveals extensive apoptosis as the probable basis for ineffective hematopoiesis. American Journal of Hematology, 48, 143-154.
6. Raza, A., Gezer, S., Mundle, S., Gao, X-Z., Alvi, S., Borok, R., Rifkin, S., Iftikhar, A., Shetty, V., Parcharidou, A., Loew, J., Marcus, B., Khan, Z., Chaney, C., Showel, J., Gregory, S. and Preisler, H. (1995). Apoptosis in bone marrow biopsy samples involving stromal and hematopoietic cells in 50 patients with myelodysplastic syndromes. Blood, 86(1), 268-276.
7. Hibner, U. and Coutinho, A. (1994). Signal antonymy: A mechanism for apoptosis induction. Cell Death & Differentiation, 1, 33-37.
8. Prchal, J. T., Throckmorton, D. W., Carroll, A. J. III, Fuson, E. W., Gams, R. A. and Prchal, J. F. (1978). A common progenitor for human myeloid and lymphoid cells. Nature, 274, 590-591.
9. Raskind, W. H., Tirumali, N., Jacobson, R., Singer, J. and Fialkow, P. J. (1984). Evidence for a multistep pathogenesis of a myelodysplastic syndrome. Blood, 63(6), 1318-1323.
10. Weimar, I. S., Bourhis, J-H., Gast, G. C. D. and Gerristen, W. R. (1993). Clonality in myelodysplastic syndromes. Leukemia and Lymphoma, 13, 215-221.
11. Janssen, J. W. G., Buschle, M., Layton, M., Drexler, H. G., Lyons, J., van den Berghe, H., Heimpel, H., Kubanek, B., Kleihauer, E., Mufti, G. J., Bartram, C. R. (1989). Clonal analysis of myelodysplastic syndromes: Evidence of multipotent stem cell origin. Blood, 73(1), 248-254.
12. van Kamp, H., Fibbe, W. E., Jansen, R. P. M., van der Keur, M., deGraaff, E., Willemze, R. and Landegent, J. E. (1992). Clonal involvement of granulocytes and monocytes but not of T and B lymphocytes and natural killer cells in patients with myelodysplasia: Analysis by X-linked restriction fragment length polymorphisms and polymerase chain reaction of the phosphoglycerate kinase gene. Blood, 80(7), 1774-1780.
13. Asano, H., Ohasi, H., Ichihara, M., Kinoshita, T., Murate, T., Kobayashi, M., Saito, H. and Hotta, T. (1994). Evidence for nonclonal hematopoietic progenitor cell populations in bone marrow of patients with myelodysplastic syndromes. Blood, 84(2), 588-594.
14. Delforge, M., Demuynck, H., Vandenberghe, P., Verhoef, G., Zachee, P., Duppen, V. V., Marijnen, P., van den Berghe, H. and Boogaerts, M. A. (1995). Polyclonal primitive hematopoietic progenitors can be detected in mobilized peripheral blood from patients with high-risk myelodysplastic syndromes. Blood, 86(1), 3660-3667.
15. Tefferi, A., Thibodeau, S. N. and Solberg, L. A. Jr. (1990). Clonal studies in the myelodysplastic syndrome using X-linked restriction fragment length polymorphisms. Blood, 75, 1770-1773.
16. Verhoef, G. E. G., Pittaluga, S., Wolf-Peeters, C. De and Boogaerts, M. A. (1995). FAB classification of myelodysplastic syndromes: merits and controversies. Annuals of Hematology, 71, 3-11.
17. Raza, A., Bokahari, J., Yousuf, N., Mehdi, A., Mazewski, C, Khan, S., Baker, V. and Lampkin, B. (1991). Cell cycle kinetic studies in human cancers: Development of three DNA-specific labels in three decades. Archives of Pathology and Laboratory Medicine, 115, 873-879.
18. Bennet, J. M., Catovsky, D., Flandrin, D. M. T., Galton, G. D. A. G., Gralnick, H. R. and Sultan, C. (1982). Proposal for the classification of the myelodysplastic syndromes. British Journal of Haematology, 51, 189-199.
19. Mundle, S. D., Clark, E., Alvi, S., Venugopal, P., Gezer, S., Borok, R., Shetty, V., Chopra, H., Hines, C., Jassak, P., Gregory, S. A., Robin, E., Rifkin, S., Alston, D., Hernandez, B., Shah, R. and Raza, A. (1996). Spontaneous apoptosis in S-phase (Signal Antonymy): A characteristic in vivo feature of myelodysplasia. Proceedings of American Society of Clinical Oncology, 15, 89, Abst #21.
20. Raza, A., Mundle, S., Shelly, V., Alvi, S., Chopra, H., Dar, S., Venugopal, P. and Borok, R., Gezer, S., Showel, J., Robin, E., Rifkin, S., Alston, D., Hernandez, B. and Gregory, S. (1996). Novel insights into the biology of Myelodysplastic Syndromes: Excessive apoptosis and the role of cytokines. International Journal of Hematology, 63, 265-278.
21. Raza, A., Preisler, H. D., Alvi, S., Venugopal, P., Gezer, S., Borok, R., Mundle, S., Shetty, V., Chopra, H., Hines, C., Jassak, P., Gregory, S. A., Robin, E., Kawauchi, R., Rifkin, S., Alston, D., Hernandez, B. and Shah, R. (1996). The dual role of tumor necrosis factor alpha in the pathogenesis of 89 patients with myelodysplastic syndromes. Proceedings of American Association of Cancer Research, 37, 191, Abst #1306.
22. Raza, A., Gezer, S., Gregory, S. A., Showel, J., Venugopal, P., Hines, C., Thomas, R., Alvi, S., Mundle, S. D., Shetty, V., Borok, R., Robin, E. L., Rifkin, S. D., Alston, D., Hernandez, B. M. and Shah, R. (1996). Anti-cytokine therapy produces modest responses in patients with myelodysplastic syndromes. Submitted to the 38th Annual Meeting of the American Society of Hematology, Orlando, Florida.
23. Greenberg, P. (1992). Treatment of myelodysplastic syndromes with hemopoietic growth factors. Seminars in Oncology, 19(1), 106-114.
24. Ganser, A. and Hoczler, D. (1992). Treatment of myelodysplastic syndromes with hematopoietic growth factors. Hematology Oncology Clinics of North America, 6(3), 633-653.
25. Negrin, R. S., Stein, R., Vardiman, J., Doherty, K., Cornwell, J., Krantz, S. and Greenberg, P. L. (1993). Treatment of the anemia of myelodysplastic syndromes using recombinant human granulocyte colony-stimulating factor in combination with erythropoietin. Blood, 82(3), 737-743.
26. Raza, A., Alvi, S., Venugopal, P., Gezer, S., Borok, R., Mundle, S., Shetty, V., Chopra, H., Hines, C., Jassak, P., Gregory, S. A., Robin, E., Rifkin, S., Alston, D., Hernandez, B. and Shah, R. (1996). Effects of Pentoxifylline/Ciprofloxacin on cytokines, apoptosis and cell cycle in patients with myelodysplastic syndromes. Proceedings of American Society of Clinical Oncology, 15, 449, Abst #1404.