Impaired hepatosplenic elimination of circulating cryoglobulins in patients with essential mixed cryoglobulinaemia and hepatitis C virus (HCV) infection

Clinical and Experimental Immunology

Volumn 110, Issue 1, 1997, Pages 9-14

  Roccatello, D ^a,f   Morsica, G ^d   Picciotto, G ^c   Cesano, G ^a   Ropolo, R ^c   Bernardi, M T ^d   Cacace, G ^c   Cavalli, G ^a   Sena, L M ^b   Lazzarin, A ^d   Piccoli, G ^a   Rifai, A ^e  

^a USL 4 Institute of Nephrology   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

^c MOLINETTE HOSPITAL   (Italy)

^d SAN RAFFAELE HOSPITAL   (Italy)

^e BROWN UNIVERSITY   (United States)

^f S GIOVANNI BOSCO HOSPITAL   (Italy)

Author keywords

Cryoglobulins; Liver; Nephritis; Scintigraphy; Spleen

Indexed keywords

ALANINE AMINOTRANSFERASE; CRYOGLOBULIN; HEPATITIS C ANTIBODY; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; IMMUNOSUPPRESSIVE AGENT; IODINE 123; RHEUMATOID FACTOR; VIRUS RNA;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL PROTOCOL; CLINICAL TRIAL; CRYOGLOBULINEMIA; CRYOPRECIPITATE; DISEASE ASSOCIATION; DRUG ELIMINATION; FEMALE; GAMMA SCINTIGRAPHY; HEPATITIS C; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE COMPLEX DEPOSITION; IMMUNE COMPLEX NEPHRITIS; IMMUNOSUPPRESSIVE TREATMENT; MALE; MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS; PLASMAPHERESIS; PRIORITY JOURNAL; RETICULOENDOTHELIAL SYSTEM; SPLEEN;

EID: 9844221408     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2249.1997.475-ce1383.x     Document Type: Article

References (16)

1. Meltzer M, Franklin EK, McCluskey RT, Cooper N. Cryoglobulinaemia: A clinical and laboratory study. Am J Med 1966; 40:837-56.
2. Abel G, Zhang QX, Agnello V, Hepatitis C virus infection in type II mixed cryoglobulinemia. Arthritis Rheum 1993; 36:1341-9.
3. Walport MJ, Peters AM, Elkon KB, Puset CD, Lavender JP, Hughes GRV. The splenic extraction ratio of antibody-coated erythrocytes and its response to plasma exchange and pulse methylprednisolone. Clin Exp Immunol 1985; 60:465-73.
4. Ng YC, Schifferli JA. Clearance of cryoglobulins in man. Springer Semin Immunopathol 1988; 10:75-89.
5. Madi N, Steiger G, Estreicher J et al. Effective immune adherence and elimination of hepatitis surface antigen/antibody complexes in patients with mixed essential cryoglobulinemia type II. J Immunol 1991; 147:495-502.
6. Ferri C, La Civita L, Longombardo G et al. Hepatitis C virus in mixed cryoglobulinaemia. Euro J Clin Invest 1993; 23:399-405.
7. Roccatello D, Picciotto G, Ropolo R et al. Kinetics and fate of IgA-IgG aggregates as a model of naturally occurring immune complexes in IgA nephropathy. Lab Invest 1992; 66:86-95.
8. Morsica G, Panese G, Novati R et al. Hepatitis C virus infection in blood donors with indeterminate results in second-generation recombinant immunoblot assay. Transfusion 1992; 34:555-6.
9. Urdea M, Horn T, Fulz T et al. Branched DNA amplification multimers for the sensitive, direct detection of human hepatitis viruses. Nucleic Acid Res 1996; 24:197-200.
10. Stuyver L, Rossau R, Wyseur A et al. Typing of hepatitis C virus isolates and characterization of new subtypes using a line probe assay. J Gen Virol 1993; 74:1093.
11. Fornasieri A, Li M, Armelloni S et al. Glomerulonephritis induced by human IgMk-IgG cryoglobulins in mice. Lab Invest 1993; 69:531-40.
12. Agnello V, Chung RT, Kaplan LM. A role for hepatitis C virus infection in type II cryoglobulinemia. N Engl J Med 1992; 327:1490-5.
13. Muller HM, Pfaff E, Goeser T, Kallinowski B, Solbach C, Theilmann L. Peripheral blood leucocytes serve as a possible extrahepatic site for hepatitis C virus replication. J Gen Virol 1993; 74:669-76.
14. Bouffard P, Hayashi PH, Acevedo R, Levi N, Zeldis JB. Hepatitis C virus is detected in a monocyte/macrophage subpopulation of peripheral blood mononuclear cells of infected patients. J Inf Dis 1992; 166:1276-80.
15. Roccatello D, Mazzucco G, Coppo R et al. Immune material processing by the phagocyte system in cryoglobulinaemia. Clin Nephrol 1991; 36:114-26.
16. Roccatello D, Isidoro C, Mazzucco G et al. Role of monocytes in cryoglobulinemia-associated nephritis. Kidney Int 1993; 43:1150-5.