Trypanocidal activity of a new diterpene from Casearia sylvestris var. lingua

Planta Medica

Volumn 70, Issue 11, 2004, Pages 1093-1095

  Espindola, Laila Salmen ^a   Rossy E Vasconcelos Jr , José ^a   De Mesquita, Mariana Laundry ^a,b   Marquié, Patrick ^a   De Paula, José Elias ^a   Mambu, Lengo ^b   Santana, Jaime Martins ^a  

^a UNIVERSITY OF BRASILIA   (Brazil)

^b MUSÉUM NATIONAL D'HISTOIRE NATURELLE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

19 ACETOXY 18,19 EPOXY 6 HYDROXY 18 BUTANOYLOXY 2 (2 METHYLBUTANOYLOXY)CLERODA 3,13(16) 14 TRIENE; ANTITRYPANOSOMAL AGENT; CASEARIA SYLVESTRIS LINGUA EXTRACT; DITERPENE; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANTIPROTOZOAL ACTIVITY; ARTICLE; BARK; BIOASSAY; CASEARIA SYLVESTRIS LINGUA; CHAGAS DISEASE; CONTROLLED STUDY; DRUG ISOLATION; FRACTIONATION; MEDICINAL PLANT; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PLANT ROOT; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; TRYPANOSOMA CRUZI; VARIETAS;

ANIMALS; CASEARIA; CHAGAS DISEASE; HUMANS; PARASITIC SENSITIVITY TESTS; PHYTOTHERAPY; PLANT EXTRACTS; PLANT ROOTS; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

CASEARIA SYLVESTRIS; PROTOZOA; TRYPANOSOMA; TRYPANOSOMA CRUZI;

EID: 9744282660     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2004-832655     Document Type: Article

References (11)

1. Coura JR, de Castro SL. A critical review on Chagas disease chemotherapy. Mem Inst Oswaldo Cruz 2002; 97: 3-24
2. Gibbons S, Gray AI, Waterman PG. Clerodane diterpenes from the bark of Casearia tremula. Phytochemistry 1996; 41: 565-70
3. Chaturvedula V, Prakash S, Hoch JM, Kingston DGI. Structure and stereochemistry of new cytotoxic clerodane diterpenoids from the bark of Casearia lucida from the Madagascar Rainforest. J Nat Prod 2002; 65:100-7
4. Hunter MS, Corley DG, Carron CP, Rowold E, Kilpatrick BF, Durley RC Four new clerodane diterpenes from the leaves of Casearia guianensis which inhibit the interaction of leukocyte function antigen 1 with intercellular adhesion molecule 1. J Nat Prod 1997; 60: 894-9
5. Oberlies NH, Burgess JP, Navarro HA, Pinos RE, Fairchild CR, Peterson RW. Novel bioactive clerodane diterpenoids from the leaves and twigs of Casearia sylvestris. J Nat Prod 2002; 65: 95-7
6. Morita H, Nakayama M, Kojima H, Takeya K, Itokawa M, Schenkel EP, Motidome M. Structures and cytotoxic activity relationship of casearins, new clerodane diterpenes from Casearia sylvestris Sw. Chem Pharm Bull 1991;39:693-7
7. Sepúlveda-Boza S, Cassels BK. Plant metabolites active against Trypanosoma cruzi. Planta Medica 1996; 62: 98-105
8. Batista R, Chiari E, Oliveira AB. Trypanosomicidal kaurane diterpenes from Wedelia paludosa. Planta Medica 1999; 65: 283-4
9. da Costa FB, Albuquerque S, Vichnewski W. Diterpenes and synthetic derivates from Viguiera aspillioides with trypanomicidal activity. Planta Medica 1996; 62: 557-9
10. Alves TM, Chaves PP, Santos LM, Nagem TJ, Murta SM, Ceravolo IP, Romanha AJ, Zani CL. A diterpene from Mikania obtusata active on Trypanosoma cruzi. Planta Medica 1995; 61: 85-7
11. Camargo EP. Growth and differentiation in Trypanosoma cruzi: 1. Origin of metacyclic trypanosomes in liquid medium. Rev Inst Med Trop de São Paulo 1964; 6: 93-100