Pathogenicity and immune prophylaxis of cag pathogenicity island gene knockout homogenic mutants

World Journal of Gastroenterology

Volumn 10, Issue 22, 2004, Pages 3289-3291

  Lin, Huan Jian ^a   Xue, Jing ^a   Bai, Yang ^a   Wang, Ji De ^a   Zhang, Ya Li ^a   Zhou, Dian Yuan ^a  

^a FIRST MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CAGA PROTEIN; HELICOBACTER PYLORI VACCINE; BACTERIAL ANTIGEN; BACTERIAL PROTEIN; CAGA PROTEIN, HELICOBACTER PYLORI;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BINDING AFFINITY; CELL PROLIFERATION; CELL STIMULATION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIUM CELL; FLOW CYTOMETRY; GENE MUTATION; HELICOBACTER INFECTION; HELICOBACTER PYLORI; IMMUNIZATION; IMMUNOPROPHYLAXIS; INFECTION PREVENTION; KNOCKOUT GENE; MOUSE; NONHUMAN; PATHOGENICITY ISLAND; SPLEEN CELL; STOMACH EPITHELIUM; STRAIN DIFFERENCE; ULTRASOUND; WILD TYPE; ANIMAL; BACTERIUM ADHERENCE; EPITHELIUM; GENETICS; IMMUNOLOGY; MICROBIOLOGY; SPLEEN; STOMACH;

ANIMALS; ANTIGENS, BACTERIAL; APOPTOSIS; BACTERIAL ADHESION; BACTERIAL PROTEINS; EPITHELIUM; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; IMMUNIZATION; MICE; SPLEEN; STOMACH;

EID: 9744255408     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v10.i22.3289     Document Type: Article

References (14)

1. Bai Y, Zhang YL, Wang JD, Zhang ZS, Zhou DY. Construction of the non-resistant attenuated Salmonella typhimurium strain expressing Helicobacter pylori catalase. Diyi Junyi Daxue Xuebao 2003; 23: 101-105
2. Vandenplas Y. Helicobacter pylori infection. World J Gastroenterol 2000; 6: 20-31
3. Blaser MJ. Hypothesis: the changing relationships of Helicobacter pylori and humans: implications for health and disease. J Infect Dis 1999; 179: 1523-1530
4. Covacci A, Censini S, Bugnoli M, Petracca R, Burroni D, Macchia G, Massone A, Papini E, Xiang Z, Figura N, Rappuoli R. Molecular characterization of the 128-kDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcer. Proc Natl Acad Sci U S A 1993; 90: 5791-5795
5. Blaser MJ, Perez-Perez GI, Kleanthous H, Cover TL, Peek RM, Chyou PH, Stemmermann GN, Nomura A. Infection with Helicobacter pylori strains possessing CagA is associated with an increased risk of developing adenocarcinoma of the stomach. Cancer Res 1995; 55 2111-2115
6. Odenbreit S, Puls J, Sedlmaier B, Gerland E, Fischer W, Haas R. Translocation of Helicobacter pylori CagA into gastric epithelial cells by type IV secretion. Science 2000; 287: 1497-1500
7. Bai Y, Dan HL, Wang JD, Zhang ZS, Odenbreit S, Zhou DY, Zhang YL. Cloning, expression, purification and identification of conservative region of four Helicobacter pylori adhesin genes in AlpA gene. Prog Biochem Biophys 2002; 29: 922-926
8. Bai Y, Zhany YL, Chen Y, Wang JD, Zhou DY. Study of Immunogenicity and safety and adherence of conservative region of four Helicobacter pylori adhesin in vitro. Prog Biochem Biophys 2003; 30: 422-426
9. Bai Y, Zhang YL, Wang JD, Zhang ZS, Zhou DY. Cloning and immunogenicity of conservative region of adhesin gene of Helicobacter pylori. Zhonghua Yixue Zazhi 2003; 83: 736-739
10. Bai Y, Wang JD, Zhang ZS, Zhang YL. Construction of the Attenuated Salmonella typhimurium strain expressing Helicobacter pylori conservative region of adhesin antigen. Chin J Biotech 2003; 19: 77-82
11. Bai Y, Chang SH, Wang JD, Chen Y, Zhang ZS, Zhang YL. Construction of the E.coli clone expressing adhesin BabA of Helicobacter pylori and evaluation of the adherence activity of BabA. Diyi Junyi Daxue Xuebao 2003; 23: 293-295
12. Bai Y, Zhang YL, Wang JD, Lin HJ, Zhang ZS, Zhou DY. Conservative region of the genes encoding four adhesins of Helicobacter pylori: cloning, sequence analysis and biological information analysis. Diyi Junyi Daxue Xuebao 2002; 22: 869-871
13. Rudnicka W, Covacci A, Wadstrom T, Chmiela M. A recombinant fragment of Helicobacter pylori CagA affects proliferation of human cells. J Physiol Pharmacol 1998; 49: 111-119
14. Wang RX, Zhang LY, Yin DL, Mufson RA, Shi Y. Protein kinase C regulates fas (CD95/APO-1) expression. J Immunol 1998; 161: 2201-2207