Roles of active site tryptophans in substrate binding and catalysis by α-1,3 galactosyltransferase

Glycobiology

Volumn 14, Issue 12, 2004, Pages 1295-1302

  Zhang, Yingnan ^a,d   Deshpande, Ashlesha ^b,e   Xie, Zhihong ^d   Natesh, Ramanathan ^c,e   Acharya, K Ravi ^e   Brew, Keith ^d  

^a GENENTECH INC   (United States)

^b CDFD   (India)

^c INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY ICGEB   (India)

^d FLORIDA ATLANTIC UNIVERSITY   (United States)

^e University of Bath   (United Kingdom)

Author keywords

Catalysis; Crystal structure; Glycosyltransferase; Mutation; Substrate binding

Indexed keywords

ALPHA 1,3 GALACTOSYLTRANSFERASE; GALACTOSYLTRANSFERASE; GLYCINE; THREONINE; TRYPTOPHAN; TYROSINE; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE GALACTOSE;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; BINDING SITE; CARBOHYDRATE TRANSPORT; CATALYSIS; CHEMICAL STRUCTURE; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME STRUCTURE; GENE MUTATION; NONHUMAN; PHASE TRANSITION; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY;

AMINO ACIDS; BINDING SITES; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; GALACTOSYLTRANSFERASES; KINETICS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPTOPHAN;

EID: 9744229199     PISSN: 09596658     EISSN: None     Source Type: Journal    
DOI: 10.1093/glycob/cwh119     Document Type: Article

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