The discovery and preparation of disubstituted novel amino-aryl-piperidine- based renin inhibitors

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 1, 2005, Pages 59-68

  Cody, Wayne L ^a   Holsworth, Daniel D ^a   Powell, Noel A ^a   Jalaie, Mehran ^a   Zhang, Erli ^a   Wang, Wei ^a   Samas, Brian ^a   Bryant, John ^a   Ostroski, Robert ^a   Ryan, Michael J ^a   Edmunds, Jeremy J ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

[4 [4 [3 (2 METHOXYBENZYLOXY)PROPOXY]PHENYL]PIPERIDIN 3 YL]NAPHTHALEN 2 YLMETHYLAMINE; PIPERIDINE DERIVATIVE; RENIN INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; FEMALE; HYPERTENSION; MALE; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; TRANSGENIC MOUSE;

ANIMALS; ANTIHYPERTENSIVE AGENTS; CRYSTALLOGRAPHY, X-RAY; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MICE, TRANSGENIC; PIPERIDINES; RENIN; STEREOISOMERISM;

MUS MUSCULUS;

EID: 9644295730     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.09.056     Document Type: Article

References (14)

1. J. Maibaum, and D.L. Feldman Exp. Opin. Ther. Pat. 13 2003 589
2. N.D.L. Fisher, and N.K. Hollenberg Expert Opin. Invest. Drugs 10 2001 417
3. H.W. Hamilton, B.W. Steinbaugh, C.J. Blankley, M.D. Taylor, O.H. Chan, B.H. Stewart, R. Schroeder, M.J. Ryan, S.T. Rapundalo, J. Cook, A. Bernabei, and C. Stewart Bioorg. Med. Chem. Lett. 3 1993 813
4. H.W. Hamilton, B.W. Steinbaugh, B.H. Stewart, H.O. Chan, H.L. Schmid, R. Schroeder, M.J. Ryan, J. Keiser, M.D. Taylor, C.J. Blankley, J.S. Kaltenbronn, J. Wright, and J. Hicks J. Med. Chem. 38 1995 1446
5. H.P. Marki, A. Binggeli, B. Bittner, V. Bohner-Lang, V. Breu, D. Bur, P. Coassolo, J.P. Clozel, A. D'Arcy, H. Doebeli, W. Fischli, C. Funk, J. Foricher, T. Giller, F. Gruninger, A. Guenzi, R. Guller, T. Hartung, G. Hirth, C. Jenny, M. Kansy, U. Klinkhammer, T. Lave, B. Lohri, F.C. Luft, E.M. Mervaala, D.N. Muller, M. Muller, F. Montavon, C. Oefner, C. Qiu, A. Reichel, P. Sanwald-Ducray, M. Scalone, M. Schleimer, R. Schmid, H. Stadler, A. Treiber, O. Valdenaire, E. Vieira, P. Waldmeier, R. Wiegand-Chou, M. Wilhelm, W. Wostl, M. Zell, and R. Zell Il Farmaco 56 2001 21
6. C. Oefner, A. Binggeli, V. Breu, D. Bur, J.-P. Clozel, A. D'Arcy, A. Dorn, W. Fischli, F. Gruninger, R. Guller, G. Hirth, H.P Marki, S. Mathews, M. Muller, R.G. Ridley, H. Stadler, E. Vieira, M. Wilhelm, F.K. Winkler, and W. Wostl Chem. Biol. 6 1999 127
7. R. Guller, A. Binggeli, V. Breu, D. Bur, W. Fischli, G. Hirth, G. Jenny, M. Kansy, F. Montavon, M. Muller, C. Oefner, H. Stadler, E. Vieira, M. Wilhelm, W. Wostl, and H.P. Marki Bioorg. Med. Chem. Lett. 9 1999 1403
8. E. Vieira, A. Binggeli, V. Breu, D. Bur, W. Fischli, R. Guller, G. Hirth, H.P. Marki, M. Muller, C. Oefner, M. Scalone, H. Stadler, M. Wilhelm, and W. Wostl Bioorg. Med. Chem. Lett. 9 1999 1397
9. J. Rahuel, V. Rasetti, J. Maibaum, H. Rueger, R. Goschke, N.-C. Cohen, S. Stutz, F. Cumin, W. Fuhrer, J.M. Wood, and M.G. Grutter Chem. Biol. 7 2000 493
10. M.G. Bursavich, C.W. West, and D.H. Rich Org. Lett. 3 2001 2317
11. M.J. Ryan, G.W. Hicks, B.L. Batley, S.T. Rapundalo, W.C. Patt, D.G. Taylor, and J.A. Keiser J. Pharmacol. Exp. Ther. 268 1994 372
12. W.C. Patt, H.H. Hamilton, M.J. Ryan, C.A. Painchaud, M.D. Taylor, S.T. Rapundalo, B.L. Batley, C.J. Connolly, and D.G. Taylor Med. Chem. Res. 2 1992 10
13. K.B. Sharpless, W. Amberg, Y.L. Bennani, G.A. Crispino, J. Hartung, K.-S. Jeong, H.-L. Kwong, K. Morkiawa, Z.-M. Wang, D. Xu, and X.-L. Zhang J. Org. Chem. 57 1992 2768
14. S.C. Nigam, A. Mann, M. Taddei, and C.-G. Wermuth Synth. Commun. 19 1989 3139