NK-1 antagonist CP99994 inhibits stress-induced mast cell degranulation in rats

Clinical and Experimental Dermatology

Volumn 29, Issue 6, 2004, Pages 644-648

  Erin, N ^a,c   Ersoy, Y ^b   Ercan, F ^b   Akici, A ^b   Oktay, S ^b  

^a AKDENIZ UNIVERSITY   (Turkey)

^b MARMARA UNIVERSITY   (Turkey)

^c PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (2 METHOXYBENZYLAMINO) 2 PHENYLPIPERIDINE; SUBSTANCE P ANTAGONIST; SUBSTANCE P RECEPTOR;

ADOLESCENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLD STRESS; CONTROLLED STUDY; DRUG EFFECT; HISTOPATHOLOGY; IMMOBILIZATION STRESS; MAST CELL DEGRANULATION; NONHUMAN; PRIORITY JOURNAL; PSORIASIS; RAT; SKIN INFLAMMATION; STRESS;

ANIMALS; CELL DEGRANULATION; COLD; DOSE-RESPONSE RELATIONSHIP, DRUG; FOOD DEPRIVATION; IMMOBILIZATION; MAST CELLS; PIPERIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NEUROKININ-1; SKIN; STRESS, PSYCHOLOGICAL; SUBSTANCE P;

EID: 9644295519     PISSN: 03076938     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2230.2004.01613.x     Document Type: Article

References (24)

1. Black PH. Stress and the inflammatory response: a review of neurogenic inflammation. Brain Behav Immun 2002; 16: 622-53.
2. Ercan F, Oktay S, Erin N. Role of afferent neurons in stress induced degenerative changes of the bladder. J Urol 2001; 165: 235-9.
3. Ozdamar SO, Seckin D, Kandemir B, Turanli AY. Mast cells in psoriasis. Dermatology 1996; 192: 190.
4. Theoharides TC, Singh LK, Boucher W et al. Corticotropin-releasing hormone induces skin mast cell degranulation and increased vascular permeability, a possible explanation for its proinflammatory effects. Endocrinology 1998; 139: 403-13.
5. Singh LK, Pang X, Alexacos N et al. Acute immobilization stress triggers skin mast cell degranulation via corticotropin releasing hormone, neurotensin, and substance P. A link to neurogenic skin disorders. Brain Behav Immun 1999; 13: 225-39.
6. Skofitsch G, Savitt JM, Jacobowitz DM. Suggestive evidence for a functional unit between mast cells and substance P fibers in the rat diaphragm and mesentery. Histochemistry 1985; 82: 5-8.
7. Toyoda M, Makino T, Kagoura M, Morohashi M. Immunolocalization of substance P in human skin mast cells. Arch Dermatol Res 2000; 292; 418-21.
8. Fehder WP, Sachs J, Uvaydova M, Douglas SD. Substance P as an immune modulator of anxiety. Neuroimmunomodulation 1997; 4: 42-8.
9. Chowdrey HS, Larsen PJ, Harbuz MS et al. Endogenous substance P inhibits the expression of corticotropin-releasing hormone during a chronic inflammatory stress. Life Sci 1995; 57: 2021-9.
10. Unger T, Carolus S, Demmert G et al. Substance P induces a cardiovascular defense reaction in the rat: pharmacological characterization. Circ Res 1988; 63: 812-20.
11. Erin N, Ercan F, Yegen BC et al. Role of capsaicin-sensitive nerves in gastric and hepatic injury induced by cold-restraint stress. Dig Dis Sci 2000; 45: 1889-99.
12. Malendowicz LK, Andreis PG, Nussdorfer GG, Markowska A. The possible role of endogenous substance P in the modulation of the response of rat pituitary-adrenal axis to stresses. Endocrinol Res 1996; 22: 311-8.
13. Matsuda H, Kawakita K, Kiso Y et al. Substance P induces granulocyte infiltration through degranulation of mast cells. J Immunol 1989; 142: 927-31.
14. Maggi CA. The mammalian tachykinin receptors. General Pharmacol 1995; 26: 911-44.
15. Cooke HJ, Fox P, Alferes L et al. Presence of NK1 receptors on a mucosal-like mast cell line, RBL-2H3 cells. Can J Physiol Pharmacol 1998; 76: 188-93.
16. Lilly CM, Hall AE, Rodger IW et al. Substance P-induced histamine release in tracheally perfused guinea pig lungs. J Appl Physiol 1995; 78: 1234-41.
17. Krumins SA, Broomfield CA. Evidence of NK1 and NK2 tachykinin receptors and their involvement in histamine release in a murine mast cell line. Neuropeptides 1992; 21: 65-72.
18. Brooks AC, Whelan CJ. Reactive oxygen species generation by mast cells in response to substance P. a NK1-receptor-mediated event. Inflamm Res 1999; 48: S121.
19. Cao T, Gerard NP, Brain SD. Use of NK (1) knockout mice to analyze substance P-induced edema formation. Am J Physiol 1999; 277: R476-81.
20. Lau AH, Chow SS, Ng YS. Immunologically induced histamine release from rat peritoneal mast cells is enhanced by low levels of substance P. Eur J Pharmacol 2001; 414: 295-303.
21. Wang ZY, Feng DM, Wang YL et al. Pharmacological assessment of spantide II analogues. Eur J Pharmacol 1994; 260: 121-8.
22. Carrasco GA, Van de Kar LD. Neuroendocrine pharmacology of stress. Eur J Pharmacol 2003; 463: 235-72.
23. Faria M, Navarra P, Tsagarakis S et al. Inhibition of CRH-41 release by substance P, but not substance K, from the rat hypothalamus in vitro. Brain Res 1991; 538: 76-8.
24. Jessop DS. Review. Central non-glucocorticoid inhibitors of the hypothalamo-pituitary-adrenal axis. J Endocrinol 1999; 160: 169-80.