Cytotoxic and antitumoral properties in a series of new, ring D modified, olivacine analogues

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 1, 2005, Pages 175-184

  Guillonneau, Claude ^a   Nault, Annette ^a   Raimbaud, Eric ^a   Léonce, Stéphane ^a   Kraus Berthier, Laurence ^a   Pierré, Alain ^a   Goldstein, Solo ^a  

^a INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

Author keywords

Antitumoral; Cytotoxic; Modified D ring; Olivacine

Indexed keywords

1 [2 (DIMETHYLAMINO)ETHYL] 2,4,5 TRIMETHYL 1,5 DIHYDROIMIDAZO[4,5 B]CARBAZOL 8 OL; 10,11 DIMETHYL 1,10 DIHYDRO[1,3]OXAZINO[4,5 B]CARBAZOLE 2,4 DIONE; 10,11 DIMETHYL 10H PYRIMIDO[4,5 B]CARBAZOLE 4 CARBONITRILE; 10,11 DIMETHYL 10H PYRIMIDO[4,5 B]CARBAZOLE 4 CARBOXAMIDE; 10,11 DIMETHYL 10H PYRIMIDO[4,5 B]CARBAZOLE 4 CARBOXYLIC SODIUM; 10,11 DIMETHYL 3,10 DIHYDRO 4H PYRIMIDO[4,5 B]CARBAZOL 4 ONE; 6 (BENZYLOXY) 1,9 DIMETHYL 3 NITRO 9H CARBAZOL 2 AMINE; 6,7 BIS[[ETHOXY(OXO)ACETYL]AMINO] 8,9 DIMETHYL 9H CARBAZOL 3 YLETHYL OXALATE; 6,7 DIAMINO 8,9 DIMETHYL 9H CARBAZOL 3 OL; 7 (DIACETYLAMINO) 8 METHYL 9H CARBAZOL 3 YL ACETATE; 7 (DIACETYLAMINO) 8,9 DIMETHYL 6 NITRO 9H CARBAZOL 3 YL ACETATE; 7 (DIACETYLAMINO) 8,9 DIMETHYL 9H CARBAZOL 3 YL ACETATE; 7 AMINO 8 METHYL 9H CARBAZOL 3 OL; 7 AMINO 8,9 DIMETHYL 6 NITRO 9H CARBAZOL 3 OL; 8 (BENZYLOXY) 2,4,5 TRIMETHYL 1,5 DIHYDROIMIDAZO[4,5 B]CARBAZOLE; [2 [8 (BENZYLOXY) 2,4,5 TRIMETHYLIMIDAZO[4,5 B]CARBAZOL 1(5H) YL]ETHYL]DIMETHYLAMINE; ANTINEOPLASTIC ALKALOID; CARBAZOLE DERIVATIVE; CHLORO 10,11 DIMETHYL 10H PYRIMIDO[4,5 B]CARBAZOLE; ETHYL 9 HYDROXY 5,6 DIMETHYL 6H PYRAZINO[2,3 B]CARBAZOLE 2 CARBOXYLATE; METHYL 10,11 DIMETHYL 10H PYRIMIDO[4,5 B]CARBAZOLE 4 CARBOXYLATE; METHYL 7 HYDROXY 10,11 DIMETHYL 10H PYRIMIDO[4,5 B]CARBAZOLE 4 CARBAZOLE 4 CARBOXYLATE; N (2 DIMETHYLAMINOETHYL) 9 HYDROXY 5,6 DIMETHYL 6H PYRIDO[4,3 B]CARBAZOLE 1 CARBOXAMIDE; N [2 (DIMETHYLAMINO)ETHYL] 7 HYDROXY 10,11 DIMETHYL 10H PYRIMIDO[4,5 B]CARBAZOLE 4 CARBOXAMIDE; N [2 (DIMETHYLAMINO)ETHYL] 8 HYDROXY 4,5 DIMETHYL 1,5 DIHYDROIMIDAZO[4,5 B]CARBAZOLE 2 CARBOXAMIDE; N [2 (DIMETHYLAMINO)ETHYL] 9 HYDROXY 5,6 DIMETHYL 6H PYRAZINO[2,3 B]CARBAZOLE 2 CARBOXAMIDE; N [2 AMINO 6 (BENZYLOXY) 1,9 DIMETHYL 9H CARBAZOL 3 YL]ACETAMIDE; NITROGEN; OLIVACINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; ATOM; CONTROLLED STUDY; CYTOTOXICITY; DRUG SYNTHESIS; ELECTRICITY; IN VIVO STUDY; LEUKEMIA L 1210; LEUKEMIA P 388; MELANOMA B16; MOLECULE; MOUSE; NONHUMAN; PARTITION COEFFICIENT;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; ELECTROSTATICS; ELLIPTICINES; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MICE; MODELS, MOLECULAR;

EID: 9644290909     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.09.047     Document Type: Article

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