Does the use of topical tranexamic acid in cardiac surgery reduce the incidence of post-operative mediastinal bleeding?

Interactive Cardiovascular and Thoracic Surgery

Volumn 3, Issue 4, 2004, Pages 603-605

  Hanif, Mohammed ^a   Nourei, Seyed Mahmoud ^a   Dunning, Joel ^a  

^a FREEMAN HOSPITAL   (United Kingdom)

Author keywords

Evidence based medicine; Post operative bleeding; Review; Thoracic surgery; Tranexamic acid

Indexed keywords

ACETYLSALICYLIC ACID; CLOPIDOGREL; HEPARIN; TRANEXAMIC ACID;

CLINICAL PROTOCOL; CLINICAL TRIAL; COCHRANE LIBRARY; EVIDENCE BASED MEDICINE; HEART SURGERY; HUMAN; INCIDENCE; MEDIASTINUM; MEDICAL RESEARCH; MEDLINE; META ANALYSIS; POSTOPERATIVE HEMORRHAGE; PRIORITY JOURNAL; REVIEW; RISK ASSESSMENT; SAMPLE SIZE; SURGICAL PATIENT;

EID: 9644288062     PISSN: 15699293     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.icvts.2004.07.005     Document Type: Review

References (4)

1. J. Dunning, B. Prendergast, and K. Mackway-Jones Towards evidence-based medicine in cardiothoracic surgery: best BETS Interact Cardiovasc Thorac Surg 2 2003 405 409
2. S.E. Fremes, B.I. Wong, E. Lee, R. Mai, G.T. Christakis, R.F. McLean, B.S. Goldman, and C.D. Naylor Metaanalysis of prophylactic drug treatment in the prevention of postoperative bleeding Ann Thorac Surg 58 1994 1580 1588
3. C. Longstaff Studies on the mechanisms of action of aprotinin and tranexamic acid as plasmin inhibitors and antifibrinolytic agents Blood Coagul Fibrinolysis 1994 537 542
4. M. De Bonis, F. Cavaliere, F. Alessandrini, E. Lapenna, F. Santarelli, U. Moscato, R. Schiavello, and G.F. Possati Topical use of tranexamic acid in coronary artery bypass operations: a double-blind, prospective, randomized, placebo-controlled study J Thorac Cardiovasc Surg 119 2000 575 580