Effects of subtoxic concentrations of benzoyl peroxide on cell lipid metabolism

Journal of Biomedical Materials Research - Part A

Volumn 71, Issue 4, 2004, Pages 685-692

  Datar, R ^a   Rueggeberg, Fredrick A ^a   Caughman, G B ^a   Wataha, John C ^a   Lewis, Jill ^a   Schuster, G S ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

Benzoyl peroxide; Cell cultures; Cytotoxicity; Lipid metabolism

Indexed keywords

CHOLESTEROL; LIPIDS; MEMBRANES; METABOLISM; PEROXIDES; TOXIC MATERIALS; TUMORS;

BENZOYL PEROXIDE (BP); TUMOR PROMOTER;

CELLS;

ACETIC ACID; ACETIC ACID C 14; BENZOIC ACID; BENZOYL PEROXIDE; CARBON 14; CHOLESTEROL; FREE RADICAL; LIPID; PHOSPHATIDYLETHANOLAMINE; PHOSPHOLIPID; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL LINE; CELL METABOLISM; CELL TYPE; CHEEK POUCH; CONTROLLED STUDY; HAMSTER; HUMAN; HUMAN CELL; LIPID METABOLISM; LIPID PEROXIDATION; MEMBRANE DAMAGE; MONOCYTE; NONHUMAN; OXIDATION REDUCTION STATE; PHOSPHOLIPID METABOLISM; THIN LAYER CHROMATOGRAPHY; TOXICITY; TUMOR PROMOTION;

ANIMALS; BENZOIC ACID; BENZOYL PEROXIDE; CELL COUNT; CELL LINE; CELL MEMBRANE PERMEABILITY; CELL PROLIFERATION; CRICETINAE; EPITHELIAL CELLS; HUMANS; KERATOLYTIC AGENTS; LIPID METABOLISM; MONOCYTES;

EID: 9644281097     PISSN: 00219304     EISSN: None     Source Type: Journal    
DOI: 10.1002/jbm.a.30207     Document Type: Article

References (24)

1. Slaga TJ, Klein-Szanto AJ, Triplett LL, Yotti LP, Trosko JE. Skin tumor-promoting activity of benzoyl peroxide, a widely used free radical generating compound. Science 1981;213:1023-1025.
2. Saran A, Pazzaglia S, Rebessi S, Bouthillier Y, Piloli C, Covelli D, Doria G, Biozzi G. Skin tumorogenesis by initiators and promoters of different chemical structures in lines of mice selectively bred for resistance or susceptibility to two-stage skin carcinogenesis. Int J Cancer 1990;83:335-340.
3. King J, Egner P, Kensler T. Generation of base modification following treatment of cultured murine keratinocytes with benzoyl peroxide. Carcinogenesis 1996;17:317-320.
4. Lawrence N, Parkinson E, Emmerson A. Benzoyl peroxide interferes with metabolic co-operation between cultured human epidermal keratinocytes. Carcinogenesis 1984;17:317-320.
5. Saladino A, Willey J, Lechner J. Effects of formaldehyde, acetaldehyde, benzoyl peroxide, and hydrogen peroxide on cultured normal human bronchial epithelial cells. Cancer Res 1985;45:2522-2526.
6. Ibbotson S, Lambert C, Moran M. Benzoyl peroxide increases UVA-induced plasma membrane damage and lipid oxidation in murine leukemia cells. J Invest Dermatol 1998;110:79-83.
7. Babich H, Zuckerbraun HL, Würzburger BJ, Rubin YL, Borenfreund E, Blau L. Benzoyl peroxide cytotoxicity evaluated in vitro with the human keratinocyte cell line, RHEK-1. Toxicology 1996;106:187-196.
8. Gopalakrishna R, Gundimeda U, Anderson WB, Colburn NH, Slaga TJ. Tumor promoter benzoyl peroxide induces sulfhydryl oxidation in protein kinase C: Its reversibility is related to the cellular resistance to peroxide-induced cyto-toxicity. Arch Biochem Biophys 1989;365:246-258.
9. Tsao M, Waltall B, Ham R. Clonal growth of normal human epidermal keratinocytes in a defined medium. J Cell Physiol 1982;110:219-229.
10. Schuster G, Lubas S, Erbland J, Singh B. Binding and uptake of N-nitrosonornicotine by oral epithelial cells. J Oral Pathol Med 1990;19:114-118.
11. Tsuchiya, Chisolm G, Collles S. Lysophosphatidylcholine-induced cellular injury in cultured fibroblasts involves oxidative events. J Lipid Res 2000;41:1188-1198.
12. Roehm N, Rodgers G, Hatfield S, Glasebrook A. An improved colorimetric assay for cell proliferation and viability utilizing the tetrazolium salt XTT 1991. J Immunol Methods 1991;142: 257-265.
13. Bligh E, Dyer W. A rapid method of total lipid extraction and purification. Can J Biochem 1959;37:911-917.
14. Schuster G, Dirksen T, Harms W. Effects of exogenous lipids on lipid synthesis by bone and bone cell cultures. J Dent Res 1975;54:131-139.
15. Marinetti G. Chromatography of lipids on commercial silica gel loaded filter paper. J Lipid Res 1965;6:315-317.
16. Rouser G, Fleischer S, Yamamoto A. Two-dimensional thin layer Chromatographic separation of polar lipids and determination of phospholipids by phosphorus analysis of spots. Lipids 1970;5:494-496.
17. Terakado M, Yamazaki M, Tsujimoto Y. Lipid peroxidation as a possible cause of benzoyl peroxide toxicity in rabbit dental pulp-A microsomal lipid peroxidation in vitro. J Dent Res 1984;63:901-905.
18. Tijburg LB, Geelen MJ, Van Golde LM. Regulation of the biosynthesis of triacylglycerol, phosphatidylcholine and phosphatidylethanolamine in the liver. Biochem Biophys Acta 1989; 1004:1-19.
19. Tijburg L, Maquedano A, Bijleveld C, Geelen M. Effects of ethanol feeding on hepatic lipid synthesis. Arch Biophys Biochem 1988;267:568-579.
20. Goldberg EM, Zidovetzki R. Effects of diplamitoylglycerol and fatty acids on membrane structure and protein kinase C activity. Biophys J 1997;73:2603-2614.
21. Maziere JC, Mora L, Auclair M, Polonovski J. Cyclic AMP increases incorporation of exogenous fatty acids into triglycerols in hamster fibroblasts. Lipids 1986;21:525-528.
22. Maury E, Commings C, Mollard P, Prevost M, Chap H. Potential role of triglycerides in signal transduction. FEBS Lett 2000; 466:228-232.
23. Slotte JP. Sphingomyelin-cholesterol interactions in biological and model membranes. Chem Phys Lipids 1999;102:13-27.
24. Dobrowsky RT. Sphingolipid signaling domains floating on rafts or buried in caves? Cell Signal 2000;12:81-90.